Tumor necrosis factor-{alpha} downregulates intestinal NHE8 expression by reducing basal promoter activity.
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NHE8 plays important roles in gastric mucosal protectionEpidermal growth factor inhibits intestinal NHE8 expression via reducing its basal transcription.Transcriptional inhibition of intestinal NHE8 expression by glucocorticoids involves Pax5.Somatostatin stimulates intestinal NHE8 expression via p38 MAPK pathwayNHE2X3 DKO mice exhibit gender-specific NHE8 compensation.Transcriptional regulation of the intestinal luminal Na⁺ and Cl⁻ transporters.Sodium butyrate stimulates NHE8 expression via its role on activating NHE8 basal promoter activity.Loss of NHE8 expression impairs intestinal mucosal integrity.Intestinal NHE8 is highly expressed in goblet cells and its expression is subject to TNF-α regulationNHE8 plays an important role in mucosal protection via its effect on bacterial adhesionPathophysiology of Intestinal Na+/H+ exchange.Epithelial transport in inflammatory bowel diseases.Role of epithelial ion transports in inflammatory bowel disease.Role of renal transporters and novel regulatory interactions in the TAL that control blood pressure.Somatostatin regulates NHE8 protein expression via the ERK1/2 MAPK pathway in DSS-induced colitis mice.Tumor necrosis factor-α represses the expression of NHE2 through NF-κB activation in intestinal epithelial cell model, C2BBe1.Involvement of NO and MEK/ERK pathway in enhancement of endothelin-1-induced mesenteric artery contraction in later-stage type 2 diabetic Goto-Kakizaki rat.
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Tumor necrosis factor-{alpha} downregulates intestinal NHE8 expression by reducing basal promoter activity.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 24 December 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
Tumor necrosis factor-{alpha} ...... ucing basal promoter activity.
@en
Tumor necrosis factor-{alpha} ...... ucing basal promoter activity.
@nl
type
label
Tumor necrosis factor-{alpha} ...... ucing basal promoter activity.
@en
Tumor necrosis factor-{alpha} ...... ucing basal promoter activity.
@nl
prefLabel
Tumor necrosis factor-{alpha} ...... ucing basal promoter activity.
@en
Tumor necrosis factor-{alpha} ...... ucing basal promoter activity.
@nl
P2093
P2860
P1476
Tumor necrosis factor-{alpha} ...... ucing basal promoter activity.
@en
P2093
Fayez K Ghishan
Huacong Chen
Jennifer K Uno
Jiali Dong
Rongji Chen
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P304
P356
10.1152/AJPCELL.00482.2008
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2008-12-24T00:00:00Z