Tissue transglutaminase: a novel pharmacological target in preventing toxic protein aggregation in neurodegenerative diseases.
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Cellular functions of tissue transglutaminasePresence of tissue transglutaminase in granular endoplasmic reticulum is characteristic of melanized neurons in Parkinson's disease brainSerotonergic dystrophy induced by excess serotonin.Aberrant calcium signaling by transglutaminase-mediated posttranslational modification of inositol 1,4,5-trisphosphate receptorsTissue transglutaminase in marmoset experimental multiple sclerosis: discrepancy between white and grey matter.Iron enhances the neurotoxicity of amyloid β.Inhibition of tissue transglutaminase promotes Aβ-induced apoptosis in SH-SY5Y cells.γ-Glutamylamines and neurodegenerative diseasesCatalytically active tissue transglutaminase colocalises with Aβ pathology in Alzheimer's disease mouse models.Transglutaminase 1 and its regulator tazarotene-induced gene 3 localize to neuronal tau inclusions in tauopathies.Transglutaminase 2 cross-linking activity is linked to invadopodia formation and cartilage breakdown in arthritis.Expression of Functional Recombinant Human Tissue Transglutaminase (TG2) Using the Bac-to-Bac Baculovirus Expression SystemNeurochemical approaches in the laboratory diagnosis of Parkinson and Parkinson dementia syndromes: a reviewPotential of transglutaminase 2 as a therapeutic target.Tissue transglutaminase: a novel therapeutic target in cerebral amyloid angiopathy.Role of tissue transglutaminase-2 (TG2)-mediated aminylation in biological processes.Strategies towards in vivo imaging of active transglutaminase type 2 using positron emission tomography.Serine 129 Phosphorylation of α-Synuclein Cross-Links with Tissue Transglutaminase to Form Lewy Body-Like Inclusion Bodies.Human tissue transglutaminase is inhibited by pharmacologic and chemical acetylation.Tissue transglutaminase-catalysed cross-linking induces Apolipoprotein E multimers inhibiting Apolipoprotein E's protective effects towards amyloid-beta-induced toxicity.Tissue transglutaminase modulates alpha-synuclein oligomerization.Transglutaminase 2 in human diseases.Tissue Transglutaminase and Its Product Isopeptide Are Increased in Alzheimer's Disease and APPswe/PS1dE9 Double Transgenic Mice BrainsTransglutaminases Derived from Astrocytes Accelerate Amyloid β Aggregation.In vivo evaluation of two tissue transglutaminase PET tracers in an orthotopic tumour xenograft model.
P2860
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P2860
Tissue transglutaminase: a novel pharmacological target in preventing toxic protein aggregation in neurodegenerative diseases.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 18 March 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Tissue transglutaminase: a nov ...... in neurodegenerative diseases.
@en
Tissue transglutaminase: a nov ...... in neurodegenerative diseases.
@nl
type
label
Tissue transglutaminase: a nov ...... in neurodegenerative diseases.
@en
Tissue transglutaminase: a nov ...... in neurodegenerative diseases.
@nl
prefLabel
Tissue transglutaminase: a nov ...... in neurodegenerative diseases.
@en
Tissue transglutaminase: a nov ...... in neurodegenerative diseases.
@nl
P1476
Tissue transglutaminase: a nov ...... in neurodegenerative diseases.
@en
P2093
Anne-Marie van Dam
Micha M M Wilhelmus
P304
P356
10.1016/J.EJPHAR.2008.01.059
P407
P577
2008-03-18T00:00:00Z