Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders
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A Randomized, placebo-controlled, crossover pilot trial of the oral selective NR2B antagonist MK-0657 in patients with treatment-resistant major depressive disorderGetting the balance right: Established and emerging therapies for major depressive disordersRapid antidepressant effects: moving right alongReplication of ketamine's antidepressant efficacy in bipolar depression: a randomized controlled add-on trialA randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depressionTowards a glutamate hypothesis of depression: an emerging frontier of neuropsychopharmacology for mood disordersStress as a one-armed bandit: Differential effects of stress paradigms on the morphology, neurochemistry and behavior in the rodent amygdala.Zinc in the Glutamatergic Theory of DepressionThe stressed synapse: the impact of stress and glucocorticoids on glutamate transmissionA review of MR spectroscopy studies of pediatric bipolar disorderThe role of glutamate and its receptors in autism and the use of glutamate receptor antagonists in treatment.Clinical and molecular genetics of psychotic depressionTargeting the glutamatergic system to treat major depressive disorder: rationale and progress to dateKetamine for treatment-resistant unipolar depression: current evidenceCell atrophy and loss in depression: reversal by antidepressant treatmentEmotional and cognitive dysregulation in schizophrenia and depression: understanding common and distinct behavioral and neural mechanisms50 years of hurdles and hope in anxiolytic drug discoveryAcute stress increases depolarization-evoked glutamate release in the rat prefrontal/frontal cortex: the dampening action of antidepressantsKetamine decreases resting state functional network connectivity in healthy subjects: implications for antidepressant drug actionLong-lasting antidepressant action of ketamine, but not glycogen synthase kinase-3 inhibitor SB216763, in the chronic mild stress model of miceChronic Treatment with the IDO1 Inhibitor 1-Methyl-D-Tryptophan Minimizes the Behavioural and Biochemical Abnormalities Induced by Unpredictable Chronic Mild Stress in Mice - Comparison with FluoxetineStress-induced changes of hippocampal NMDA receptors: modulation by duloxetine treatmentNew therapeutic targets for mood disordersGenome-wide association scan of trait depressionIs it really a matter of simple dualism? Corticotropin-releasing factor receptors in body and mental health.Using an experimental medicine model to understand the antidepressant potential of the N-Methyl-D-aspartic acid (NMDA) receptor antagonist memantineNew frontiers in animal research of psychiatric illnessInvolvement of NMDAR2A tyrosine phosphorylation in depression-related behaviour.Acute D-serine treatment produces antidepressant-like effects in rodentsForebrain glutamatergic neurons mediate leptin action on depression-like behaviors and synaptic depressionLocal potentiation of excitatory synapses by serotonin and its alteration in rodent models of depressionThe absence of P2X7 receptors (P2rx7) on non-haematopoietic cells leads to selective alteration in mood-related behaviour with dysregulated gene expression and stress reactivity in mice.Socially responsive effects of brain oxidative metabolism on aggression.The Utility of Magnetic Resonance Spectroscopy for Understanding Substance Use Disorders: A Systematic Review of the LiteratureInflammation Effects on Brain Glutamate in Depression: Mechanistic Considerations and Treatment Implications.Amino acid neurotransmitters assessed by proton magnetic resonance spectroscopy: relationship to treatment resistance in major depressive disorder.Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants.From synapse to nucleus: novel targets for treating depression.Elevated level of metabotropic glutamate receptor 2/3 in the prefrontal cortex in major depression.The association of interoceptive awareness and alexithymia with neurotransmitter concentrations in insula and anterior cingulate
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P2860
Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on May 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Targeting the glutamatergic sy ...... herapeutics for mood disorders
@en
Targeting the glutamatergic sy ...... erapeutics for mood disorders.
@nl
type
label
Targeting the glutamatergic sy ...... herapeutics for mood disorders
@en
Targeting the glutamatergic sy ...... erapeutics for mood disorders.
@nl
prefLabel
Targeting the glutamatergic sy ...... herapeutics for mood disorders
@en
Targeting the glutamatergic sy ...... erapeutics for mood disorders.
@nl
P2093
P2860
P356
P1476
Targeting the glutamatergic sy ...... herapeutics for mood disorders
@en
P2093
Carlos A Zarate
Gerard Sanacora
Husseini K Manji
John H Krystal
P2860
P2888
P304
P356
10.1038/NRD2462
P577
2008-05-01T00:00:00Z