Comparative studies of Munc18c and Munc18-1 reveal conserved and divergent mechanisms of Sec1/Munc18 proteins.
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Neurotransmitter release: the last millisecond in the life of a synaptic vesicleReconciling the regulatory role of Munc18 proteins in SNARE-complex assemblyCa²⁺-regulated secretory granule exocytosis in pancreatic and parotid acinar cellsDifferential Effects of Munc18s on Multiple Degranulation-Relevant Trans-SNARE ComplexesInsulin stimulates syntaxin4 SNARE complex assembly via a novel regulatory mechanismMunc13-4 functions as a Ca2+ sensor for homotypic secretory granule fusion to generate endosomal exocytic vacuoles.The N- and C-terminal domains of tomosyn play distinct roles in soluble N-ethylmaleimide-sensitive factor attachment protein receptor binding and fusion regulationCommon intermediates and kinetics, but different energetics, in the assembly of SNARE proteins.Munc18c: a controversial regulator of peripheral insulin action.Milligram quantities of homogeneous recombinant full-length mouse Munc18c from Escherichia coli cultures.Hemophagocytic lymphohistiocytosis caused by dominant-negative mutations in STXBP2 that inhibit SNARE-mediated membrane fusion.Synaptotagmin-1 is an antagonist for Munc18-1 in SNARE zippering.Doc2b serves as a scaffolding platform for concurrent binding of multiple Munc18 isoforms in pancreatic islet β-cellsReconstituting Intracellular Vesicle Fusion Reactions: The Essential Role of Macromolecular CrowdingThe trans-SNARE-regulating function of Munc18-1 is essential to synaptic exocytosisTowards reconstitution of membrane fusion mediated by SNAREs and other synaptic proteinsQuantitative Proteomic Analysis Reveals Molecular Adaptations in the Hippocampal Synaptic Active Zone of Chronic Mild Stress-Unsusceptible Rats.Extended synaptotagmins are Ca2+-dependent lipid transfer proteins at membrane contact sites.Functional synergy between the Munc13 C-terminal C1 and C2 domains.Two gigs of Munc18 in membrane fusion.Sec3 promotes the initial binary t-SNARE complex assembly and membrane fusion.CAPS and Munc13: CATCHRs that SNARE VesiclesA unique SNARE machinery for exocytosis of cytotoxic granules and platelets granules.C2-domain containing calcium sensors in neuroendocrine secretion.Syntaxin 4 mediates endosome recycling for lytic granule exocytosis in cytotoxic T-lymphocytes.Munc18c mediates exocytosis of pre-docked and newcomer insulin granules underlying biphasic glucose stimulated insulin secretion in human pancreatic beta-cells.The nature of the Syntaxin4 C-terminus affects Munc18c-supported SNARE assembly.Revisiting interaction specificity reveals neuronal and adipocyte Munc18 membrane fusion regulatory proteins differ in their binding interactions with partner SNARE Syntaxins.Evidence for a conserved inhibitory binding mode between the membrane fusion assembly factors Munc18 and syntaxin in animals.Simultaneous lipid and content mixing assays for in vitro reconstitution studies of synaptic vesicle fusion.Munc18a clusters SNARE-bearing liposomes prior to trans-SNARE zippering.Interaction of Munc18c and syntaxin4 facilitates invadopodium formation and extracellular matrix invasion of tumor cells.RABIF/MSS4 is a Rab-stabilizing holdase chaperone required for GLUT4 exocytosis.Diverse exocytic pathways for mast cell mediators.
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Comparative studies of Munc18c and Munc18-1 reveal conserved and divergent mechanisms of Sec1/Munc18 proteins.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 05 August 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Comparative studies of Munc18c ...... nisms of Sec1/Munc18 proteins.
@en
Comparative studies of Munc18c ...... nisms of Sec1/Munc18 proteins.
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label
Comparative studies of Munc18c ...... nisms of Sec1/Munc18 proteins.
@en
Comparative studies of Munc18c ...... nisms of Sec1/Munc18 proteins.
@nl
prefLabel
Comparative studies of Munc18c ...... nisms of Sec1/Munc18 proteins.
@en
Comparative studies of Munc18c ...... nisms of Sec1/Munc18 proteins.
@nl
P2093
P2860
P50
P356
P1476
Comparative studies of Munc18c ...... anisms of Sec1/Munc18 proteins
@en
P2093
Eric M Davis
Jamie A Lopez
Shailendra S Rathore
P2860
P304
P356
10.1073/PNAS.1311232110
P407
P577
2013-08-05T00:00:00Z