Withaferin A: a proteasomal inhibitor promotes healing after injury and exerts anabolic effect on osteoporotic bone.
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Withaferin A disrupts ubiquitin-based NEMO reorganization induced by canonical NF-κB signalingJNK-NQO1 axis drives TAp73-mediated tumor suppression upon oxidative and proteasomal stressRNAi and Homologous Over-Expression Based Functional Approaches Reveal Triterpenoid Synthase Gene-Cycloartenol Synthase Is Involved in Downstream Withanolide Biosynthesis in Withania somniferaNovel Methods to Generate Active Ingredients-Enriched Ashwagandha Leaves and ExtractsComparative transcriptome analysis of different chemotypes elucidates withanolide biosynthesis pathway from medicinal plant Withania somniferaInvestigational drugs for fracture healing: preclinical & clinical data.Characterization of Withania somnifera leaf transcriptome and expression analysis of pathogenesis-related genes during salicylic acid signaling.Proteasome inhibitor MG132 inhibits the proliferation and promotes the cisplatin-induced apoptosis of human esophageal squamous cell carcinoma cells.Withaferin A Inhibits STAT3 and Induces Tumor Cell Death in Neuroblastoma and Multiple MyelomaComparative interactions of withanolides and sterols with two members of sterol glycosyltransferases from Withania somnifera.A novel therapeutic approach with Caviunin-based isoflavonoid that en routes bone marrow cells to bone formation via BMP2/Wnt-β-catenin signalingStructure Model Index Does Not Measure Rods and Plates in Trabecular Bone.Withanolide E sensitizes renal carcinoma cells to TRAIL-induced apoptosis by increasing cFLIP degradation.MicroRNA 874-3p Exerts Skeletal Anabolic Effects Epigenetically during Weaning by Suppressing Hdac1 Expression.Genetically engineered flavonol enriched tomato fruit modulates chondrogenesis to increase bone length in growing animals.RNAi-mediated gene silencing of WsSGTL1 in W.somnifera affects growth and glycosylation pattern.Fast method for skeletal tissue gene expression analysis.Osteoblast dysfunctions in bone diseases: from cellular and molecular mechanisms to therapeutic strategies.Withaferin A Inhibits Nuclear Factor-κB-Dependent Pro-Inflammatory and Stress Response Pathways in the Astrocytes.Chemistry of withaferin-A: chemo, regio, and stereoselective synthesis of novel spiro-pyrrolizidino-oxindole adducts of withaferin-A via one-pot three-component [3+2] azomethine ylide cycloaddition and their cytotoxicity evaluation.The E3 ligase Itch knockout mice show hyperproliferation and wound healing alteration.WsSGTL1 gene from Withania somnifera, modulates glycosylation profile, antioxidant system and confers biotic and salt stress tolerance in transgenic tobacco.Formononetin, an isoflavone, activates AMP-activated protein kinase/β-catenin signalling to inhibit adipogenesis and rescues C57BL/6 mice from high-fat diet-induced obesity and bone loss.An isoflavone cladrin prevents high-fat diet-induced bone loss and inhibits the expression of adipogenic gene regulators in 3T3-L1 adipocyte.Co-expression of Arabidopsis transcription factor, AtMYB12, and soybean isoflavone synthase, GmIFS1, genes in tobacco leads to enhanced biosynthesis of isoflavones and flavonols resulting in osteoprotective activity.Virus-Induced Silencing of Key Genes Leads to Differential Impact on Withanolide Biosynthesis in Medicinal Plant, Withania somnifera.Sterol glycosyltransferases required for adaptation of Withania somnifera at high temperature.Using the Connectivity Map to discover compounds influencing human osteoblast differentiation.Bortezomib prevents ovariectomy-induced osteoporosis in mice by inhibiting osteoclast differentiation.Functional block of IL-17 cytokine promotes bone healing by augmenting FOXO1 and ATF4 activity in cortical bone defect model.Micro-architectural changes in cancellous bone differ in female and male C57BL/6 mice with high-fat diet-induced low bone mineral density.Local application of a proteasome inhibitor enhances fracture healing in rats.Comprehensive assessment of the genes involved in withanolide biosynthesis from Withania somnifera: chemotype-specific and elicitor-responsive expression.
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P2860
Withaferin A: a proteasomal inhibitor promotes healing after injury and exerts anabolic effect on osteoporotic bone.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 22 August 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Withaferin A: a proteasomal in ...... c effect on osteoporotic bone.
@en
Withaferin A: a proteasomal in ...... c effect on osteoporotic bone.
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type
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Withaferin A: a proteasomal in ...... c effect on osteoporotic bone.
@en
Withaferin A: a proteasomal in ...... c effect on osteoporotic bone.
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prefLabel
Withaferin A: a proteasomal in ...... c effect on osteoporotic bone.
@en
Withaferin A: a proteasomal in ...... c effect on osteoporotic bone.
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P2093
P2860
P356
P1476
Withaferin A: a proteasomal in ...... c effect on osteoporotic bone.
@en
P2093
B Changkija
N S Sangwan
P K Trivedi
P Kushwaha
P R Mishra
P2860
P2888
P356
10.1038/CDDIS.2013.294
P577
2013-08-22T00:00:00Z
P5875
P6179
1049096971