A genome-wide association study identifies three loci associated with mean platelet volume
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A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americansIndividuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathyReplication and characterisation of genetic variants in the fibrinogen gene cluster with plasma fibrinogen levels and haematological traits in the Third National Health and Nutrition Examination SurveyGenome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1Imputation of exome sequence variants into population- based samples and blood-cell-trait-associated loci in African Americans: NHLBI GO Exome Sequencing Project.Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia.The genetics of platelet count and volume in humans.PLA1A2 platelet polymorphism predicts mortality in prediabetic subjects of the population based KORA S4-CohortSNP in human ARHGEF3 promoter is associated with DNase hypersensitivity, transcript level and platelet function, and Arhgef3 KO mice have increased mean platelet volume.Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.Genetic regulation of platelet receptor expression and function: application in clinical practice and drug development.The genetics of normal platelet reactivity.Transcription profiling in human platelets reveals LRRFIP1 as a novel protein regulating platelet function.Genetic association analysis under complex survey sampling: the Hispanic Community Health Study/Study of Latinos.Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists.Genome-wide association study reveals constant and specific loci for hematological traits at three time stages in a White Duroc × Erhualian F2 resource populationOptimized metabolomic approach to identify uremic solutes in plasma of stage 3-4 chronic kidney disease patients.A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.Power and instrument strength requirements for Mendelian randomization studies using multiple genetic variants.The genetics of common variation affecting platelet development, function and pharmaceutical targeting.Mapping the genetic architecture of gene regulation in whole bloodAbsence of an orphan mitochondrial protein, c19orf12, causes a distinct clinical subtype of neurodegeneration with brain iron accumulation.Dissecting the genetics of the human transcriptome identifies novel trait-related trans-eQTLs and corroborates the regulatory relevance of non-protein coding loci†.New gene functions in megakaryopoiesis and platelet formationGenetic association analysis highlights new loci that modulate hematological trait variation in Caucasians and African Americans.Wdr66 is a novel marker for risk stratification and involved in epithelial-mesenchymal transition of esophageal squamous cell carcinoma.GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children.From GWAS to function: lessons from blood cells.Characterization of the platelet transcriptome by RNA sequencing in patients with acute myocardial infarction.A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects.Identification of ITGA2B and ITGB3 Single-Nucleotide Polymorphisms and Their Influences on the Platelet FunctionA common FADS2 promoter polymorphism increases promoter activity and facilitates binding of transcription factor ELK1.Lessons and Implications from Genome-Wide Association Studies (GWAS) Findings of Blood Cell Phenotypes.Lessons from genome-wide association studies in venous thrombosis.Common genetic factors for hematological traits in humans.Genome-wide association studies of hematologic phenotypes: a window into human hematopoiesis.Platelet genomics: the role of platelet size and number in health and disease.Smaller platelet volumes associated with vascular malformations.Batch effects in the BRLMM genotype calling algorithm influence GWAS results for the Affymetrix 500K array.Cohort Profile: The Study of Health in Pomerania
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A genome-wide association study identifies three loci associated with mean platelet volume
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 24 December 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A genome-wide association stud ...... ated with mean platelet volume
@en
A genome-wide association stud ...... ted with mean platelet volume.
@nl
type
label
A genome-wide association stud ...... ated with mean platelet volume
@en
A genome-wide association stud ...... ted with mean platelet volume.
@nl
prefLabel
A genome-wide association stud ...... ated with mean platelet volume
@en
A genome-wide association stud ...... ted with mean platelet volume.
@nl
P2093
P2860
P50
P1476
A genome-wide association stud ...... ated with mean platelet volume
@en
P2093
Christian Rimmbach
Dieter Rosskopf
H-Erich Wichmann
Jonathan Stephens
Matthias Nauck
Nicholas A Watkins
P2860
P356
10.1016/J.AJHG.2008.11.015
P407
P50
P577
2008-12-24T00:00:00Z