Established and new mouse models reveal E2f1 and Cdk2 dependency of retinoblastoma, and expose effective strategies to block tumor initiation.
about
The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycleRB1: a prototype tumor suppressor and an enigmaInduction of the ganglion cell differentiation program in human retinal progenitors before cell cycle exit.Chromatin remodelers HELLS and UHRF1 mediate the epigenetic deregulation of genes that drive retinoblastoma tumor progression.E2F inhibition synergizes with paclitaxel in lung cancer cell linesThe retinoblastoma tumor suppressor and stem cell biology.Retinal horizontal cells lacking Rb1 sustain persistent DNA damage and survive as polyploid giant cells.E2f2 induces cone photoreceptor apoptosis independent of E2f1 and E2f3Retinoblastoma: concerning its initiation and treatment.Bioinformatic identification of prognostic signature defined by copy number alteration and expression of CCNE1 in non-muscle invasive bladder cancer.A mouse model of MYCN-driven retinoblastoma reveals MYCN-independent tumor reemergence.Antitumor mechanisms when pRb and p53 are genetically inactivated.Rb and p107 are required for alpha cell survival, beta cell cycle control and glucagon-like peptide-1 action.Genetic and molecular analyses reveal G6PC as a key element connecting glucose metabolism and cell cycle control in ovarian cancer.A CDK2 activity signature predicts outcome in CDK2-low cancers.Optical coherence tomography enables imaging of tumor initiation in the TAg-RB mouse model of retinoblastoma.Cancer: The origin of human retinoblastoma.Cooperation between Rb and Arf in suppressing mouse retinoblastoma.Defining a new vision for the retinoblastoma gene: report from the 3rd International Rb MeetingRb suppresses human cone-precursor-derived retinoblastoma tumours.p16Ink4a and p21Cip1/Waf1 promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis.SKP2 Activation by Thyroid Hormone Receptor β2 Bypasses Rb-Dependent Proliferation in Rb-Deficient Cells.E2F/DP Prevents Cell-Cycle Progression in Endocycling Fat Body Cells by Suppressing dATM Expression.Rb is required for retinal angiogenesis and lamination.Chromatin remodeling protein HELLS is upregulated by inactivation of the RB-E2F pathway and is nonessential for osteosarcoma tumorigenesisRetinoblastoma
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P2860
Established and new mouse models reveal E2f1 and Cdk2 dependency of retinoblastoma, and expose effective strategies to block tumor initiation.
description
2012 nî lūn-bûn
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2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
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2012年學術文章
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2012年學術文章
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name
Established and new mouse mode ...... ies to block tumor initiation.
@en
Established and new mouse mode ...... ies to block tumor initiation.
@nl
type
label
Established and new mouse mode ...... ies to block tumor initiation.
@en
Established and new mouse mode ...... ies to block tumor initiation.
@nl
prefLabel
Established and new mouse mode ...... ies to block tumor initiation.
@en
Established and new mouse mode ...... ies to block tumor initiation.
@nl
P2093
P2860
P356
P1433
P1476
Established and new mouse mode ...... ies to block tumor initiation.
@en
P2093
P2860
P2888
P304
P356
10.1038/ONC.2011.654
P407
P577
2012-01-30T00:00:00Z
P5875
P6179
1020255993