Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mixed mu-agonist/delta-antagonist and dual mu-agonist/delta-agonist opioid ligands.

Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mixed mu-agonist/delta-antagonist and dual mu-agonist/delta-agonist opioid ligands.

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http://www.wikidata.org/entity/Q37159251
Developmental potential for endomorphin opioidmimetic drugsBi- or multifunctional opioid peptide drugs.Proton sharing and transfer in some zwitterionic compounds based on 4-oxo-4-((1-phenethylpiperidin-4-yl)(phenyl)amino)alcanoic acids.Engineering endomorphin drugs: state of the art.Targeting delta opioid receptors for pain treatment: drugs in phase I and II clinical development.Molecular Pharmacology of δ-Opioid Receptors.[Dmt(1)]DALDA analogues with enhanced μ opioid agonist potency and with a mixed μ/κ opioid activity profileEndomorphins: potential roles and therapeutic indications in the development of opioid peptide analgesic drugs.Opioid receptor targeting ligands for pain management: a review and update.2',6'-dimethylphenylalanine: a useful aromatic amino Acid surrogate for tyr or phe residue in opioid peptides.Targeting multiple opioid receptors - improved analgesics with reduced side effects?Asymmetric synthesis and in vitro and in vivo activity of tetrahydroquinolines featuring a diverse set of polar substitutions at the 6 position as mixed-efficacy μ opioid receptor/δ opioid receptor ligands.Rapid Synthesis of Boc-2',6'-dimethyl-l-tyrosine and Derivatives and Incorporation into Opioid Peptidomimetics.Exploring the biological consequences of conformational changes in aspartame models containing constrained analogues of phenylalaninePreparation of Constrained Unnatural Aromatic Amino AcidsviaUnsaturated Diketopiperazine Intermediate
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Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mixed mu-agonist/delta-antagonist and dual mu-agonist/delta-agonist opioid ligands.

Item
http://www.wikidata.org/entity/Q37159251
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 12 May 2007
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Bifunctional [2',6'-dimethyl-L ...... /delta-agonist opioid ligands.
@en
Bifunctional [2',6'-dimethyl-L ...... /delta-agonist opioid ligands.
@nl
type
label
Bifunctional [2',6'-dimethyl-L ...... /delta-agonist opioid ligands.
@en
Bifunctional [2',6'-dimethyl-L ...... /delta-agonist opioid ligands.
@nl
prefLabel
Bifunctional [2',6'-dimethyl-L ...... /delta-agonist opioid ligands.
@en
Bifunctional [2',6'-dimethyl-L ...... /delta-agonist opioid ligands.
@nl
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P1476
P2093
P2860
P304
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P478
P577
P5875
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P1433
P1476
Bifunctional [2',6'-dimethyl-L ...... /delta-agonist opioid ligands.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P921
P932