Targeting protein tyrosine phosphatase SHP2 for the treatment of PTPN11-associated malignancies
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Selective inhibitors of the protein tyrosine phosphatase SHP2 block cellular motility and growth of cancer cells in vitro and in vivoTherapeutic potential of targeting the oncogenic SHP2 phosphatase.Protein tyrosine phosphatases as potential therapeutic targets.Retrospective review using targeted deep sequencing reveals mutational differences between gastroesophageal junction and gastric carcinomas.Irreversible dual inhibitory mode: the novel Btk inhibitor PLS-123 demonstrates promising anti-tumor activity in human B-cell lymphoma.Functions of Shp2 in cancer.Shp2 and Pten have antagonistic roles in myeloproliferation but cooperate to promote erythropoiesis in mammalsDiscovery of a Novel Inhibitor of the Protein Tyrosine Phosphatase Shp2.Targeting protein tyrosine phosphatase SHP2 for therapeutic intervention.Systemic treatment in EGFR-ALK NSCLC patients: second line therapy and beyond.Predicting resistance by selection of signaling pathways.Mutations in EMT-Related Genes in ALK Positive Crizotinib Resistant Non-Small Cell Lung Cancers.Protein tyrosine phosphatases in cardiac physiology and pathophysiology.Identification of protein tyrosine phosphatase SHP-2 as a new target of perfluoroalkyl acids in HepG2 cells.HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis.Gain-of-function mutations in the gene encoding the tyrosine phosphatase SHP2 induce hydrocephalus in a catalytically dependent manner.
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Targeting protein tyrosine phosphatase SHP2 for the treatment of PTPN11-associated malignancies
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 03 July 2013
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Targeting protein tyrosine pho ...... PTPN11-associated malignancies
@en
Targeting protein tyrosine pho ...... TPN11-associated malignancies.
@nl
type
label
Targeting protein tyrosine pho ...... PTPN11-associated malignancies
@en
Targeting protein tyrosine pho ...... TPN11-associated malignancies.
@nl
prefLabel
Targeting protein tyrosine pho ...... PTPN11-associated malignancies
@en
Targeting protein tyrosine pho ...... TPN11-associated malignancies.
@nl
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P2860
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Targeting protein tyrosine pho ...... PTPN11-associated malignancies
@en
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Cheng-Kui Qu
Li-Da Tang
Mignon L Loh
Olgun Guvench
Shawn Alter
Wen-Mei Yu
P2860
P304
P356
10.1158/1535-7163.MCT-13-0049-T
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2013-07-03T00:00:00Z