PDZK1 is a novel factor in breast cancer that is indirectly regulated by estrogen through IGF-1R and promotes estrogen-mediated growth. - Wikidata - awgldk - TriplyDB

PDZK1 is a novel factor in breast cancer that is indirectly regulated by estrogen through IGF-1R and promotes estrogen-mediated growth.

PDZK1 is a novel factor in breast cancer that is indirectly regulated by estrogen through IGF-1R and promotes estrogen-mediated growth.

http://www.wikidata.org/entity/Q37161525

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Potential role of High mobility group box 1 in hepatocellular carcinoma Lipopolysaccharide-induced NF-κB nuclear translocation is primarily dependent on MyD88, but TNFα expression requires TRIF and MyD88 Alarmins and central nervous system inflammation in HIV-associated neurological disorders.Translating extranuclear steroid receptor signaling to clinical medicine.Molecular mechanism and therapeutic modulation of high mobility group box 1 release and action: an updated review.Fulvestrant-3 Boronic Acid (ZB716): An Orally Bioavailable Selective Estrogen Receptor Downregulator (SERD).Correlation between PDZK1, Cdc37, Akt and breast cancer malignancy: the role of PDZK1 in cell growth through Akt stabilization by increasing and interacting with Cdc37 Lentivirus delivery of IL-10 to promote and sustain macrophage polarization towards an anti-inflammatory phenotype.CD13 restricts TLR4 endocytic signal transduction in inflammation.Contributions of unique intracellular domains to switchlike biosensing by Toll-like receptor 4.Poly(ADP-ribose) polymerase as a novel regulator of 17β-estradiol-induced cell growth through a control of the estrogen receptor/IGF-1 receptor/PDZK1 axis Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer High-mobility group protein box1 expression correlates with peritumoral macrophage infiltration and unfavorable prognosis in patients with hepatocellular carcinoma and cirrhosis Prognostic value of HMGB1 in early breast cancer patients under neoadjuvant chemotherapy.Tumor suppressor ING4 inhibits estrogen receptor activity in breast cancer cells.Low level of PDZ domain containing 1 (PDZK1) predicts poor clinical outcome in patients with clear cell renal cell carcinoma High-mobility group box-1 in sterile inflammation.The role of Toll-like receptor 4 (TLR4) in cardiac ischaemic-reperfusion injury, cardioprotection and preconditioning.Levobupivacaine attenuates lipopolysaccharide-induced acute lung injury.Bromodomain inhibition shows antitumoral activity in mice and human luminal breast cancer.CD14 is a key organizer of microglial responses to CNS infection and injury.Estradiol-ERβ2 signaling axis confers growth and migration of CRPC cells through TMPRSS2-ETV5 gene fusion.Downregulation of PDZ Domain Containing 1 (PDZK1) is a Poor Prognostic Marker for Clear Cell Renal Cell Carcinoma.PDZ-containing 1 acts as a suppressor of pancreatic cancer by regulating PTEN phosphorylation.Dengue fatal cases present virus-specific HMGB1 response in peripheral organs.The damage-associated molecular pattern HMGB1 is elevated in human alcoholic hepatitis, but does not seem to be a primary driver of inflammation.Pharmacophore modeling for identification of anti-IGF-1R drugs and in-vitro validation of fulvestrant as a potential inhibitor.

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PDZK1 is a novel factor in breast cancer that is indirectly regulated by estrogen through IGF-1R and promotes estrogen-mediated growth.

http://www.wikidata.org/entity/Q37161525

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 28 August 2013

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

PDZK1 is a novel factor in bre ...... otes estrogen-mediated growth.

@en

PDZK1 is a novel factor in bre ...... otes estrogen-mediated growth.

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type

label

PDZK1 is a novel factor in bre ...... otes estrogen-mediated growth.

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PDZK1 is a novel factor in bre ...... otes estrogen-mediated growth.

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prefLabel

PDZK1 is a novel factor in bre ...... otes estrogen-mediated growth.

@en

PDZK1 is a novel factor in bre ...... otes estrogen-mediated growth.

@nl

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MOLMED.2011.00001

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Molecular Medicine

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PDZK1 is a novel factor in bre ...... otes estrogen-mediated growth.

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A Hamid Boulares

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Amarjit S Naura

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Andrew Catling

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Asim B Abdel-Mageed

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Dennis Paul

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Hogyoung Kim

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Jihang Ju

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Jong G Kim

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Shibu Varughese

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Suresh Alahari

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P2860

Identification and partial characterization of PDZK1: a novel protein containing PDZ interaction domains

NCBI GEO: mining tens of millions of expression profiles--database and tools update

Targeted disruption of the PDZK1 gene in mice causes tissue-specific depletion of the high density lipoprotein receptor scavenger receptor class B type I and altered lipoprotein metabolism

Modulation of in situ estrogen synthesis by proline-, glutamic acid-, and leucine-rich protein-1: potential estrogen receptor autocrine signaling loop in breast cancer cells

Crosstalk between steroid receptors and the c-Src-receptor tyrosine kinase pathways: implications for cell proliferation.

Novel actions of estrogen to promote proliferation: integration of cytoplasmic and nuclear pathways.

Estrogen signaling via a linear pathway involving insulin-like growth factor I receptor, matrix metalloproteinases, and epidermal growth factor receptor to activate mitogen-activated protein kinase in MCF-7 breast cancer cells.

Estrogen signals via an extra-nuclear pathway involving IGF-1R and EGFR in tamoxifen-sensitive and -resistant breast cancer cells.

PDZK1 and GREB1 are estrogen-regulated genes expressed in hormone-responsive breast cancer.

A stromal gene signature associated with inflammatory breast cancer.

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