Restriction by SAMHD1 Limits cGAS/STING-Dependent Innate and Adaptive Immune Responses to HIV-1.
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Lack of Trex1 Causes Systemic Autoimmunity despite the Presence of Antiretroviral Drugs.A Highly Active Isoform of Lentivirus Restriction Factor SAMHD1 in Mouse.Roles of SAMHD1 in antiviral defense, autoimmunity and cancer.Regulating STING in health and diseaseRole of Innate Genes in HIV Replication.Length does matter for cGAS.A SAMHD1 mutation associated with Aicardi-Goutières syndrome uncouples the ability of SAMHD1 to restrict HIV-1 from its ability to downmodulate type I interferon in humans.Interferons Induce Expression of SAMHD1 in Monocytes through Down-regulation of miR-181a and miR-30a.The Significance of Type-I Interferons in the Pathogenesis and Therapy of Human Immunodeficiency Virus 1 Infection.Type I interferon-mediated autoinflammation due to DNase II deficiency.The Dynamic Interplay between HIV-1, SAMHD1, and the Innate Antiviral Response.A central role for PI3K-AKT signaling pathway in linking SAMHD1-deficiency to the type I interferon signature.SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-κB and interferon pathways.SAMHD1: Recurring roles in cell cycle, viral restriction, cancer, and innate immunity.
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Restriction by SAMHD1 Limits cGAS/STING-Dependent Innate and Adaptive Immune Responses to HIV-1.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 27 July 2016
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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Restriction by SAMHD1 Limits c ...... ive Immune Responses to HIV-1.
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Restriction by SAMHD1 Limits c ...... ive Immune Responses to HIV-1.
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Restriction by SAMHD1 Limits c ...... ive Immune Responses to HIV-1.
@en
Restriction by SAMHD1 Limits c ...... ive Immune Responses to HIV-1.
@nl
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Restriction by SAMHD1 Limits c ...... ive Immune Responses to HIV-1.
@en
Restriction by SAMHD1 Limits c ...... ive Immune Responses to HIV-1.
@nl
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Restriction by SAMHD1 Limits c ...... ive Immune Responses to HIV-1.
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Adel Benlahrech
Chiara Cursi
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10.1016/J.CELREP.2016.07.002
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2016-07-27T00:00:00Z