Ascomycin and FK506: pharmacology and therapeutic potential as anticonvulsants and neuroprotectants.
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The Emerging Roles of the Calcineurin-Nuclear Factor of Activated T-Lymphocytes Pathway in Nervous System Functions and DiseasesCyclosporine A, FK506, and NIM811 ameliorate prolonged CBF reduction and impaired neurovascular coupling after cortical spreading depression.Improvement of FK506 production in Streptomyces tsukubaensis by genetic enhancement of the supply of unusual polyketide extender units via utilization of two distinct site-specific recombination systems.Long-term habituation of the gill-withdrawal reflex in aplysia requires gene transcription, calcineurin and L-type voltage-gated calcium channels.Improved FK506 production by the precursors and product-tolerant mutant of Streptomyces tsukubaensis based on genome shuffling and dynamic fed-batch strategies.Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues.Roles of fkbN in positive regulation and tcs7 in negative regulation of FK506 biosynthesis in Streptomyces sp. strain KCTC 11604BPCognitive decline in Alzheimer's disease is associated with selective changes in calcineurin/NFAT signaling.Trends in the biosynthesis and production of the immunosuppressant tacrolimus (FK506).The biosynthetic pathway of FK506 and its engineering: from past achievements to future prospects.Randomized controlled studies on the efficacy of antiarthritic agents in inhibiting cartilage degeneration and pain associated with progression of osteoarthritis in the rat.Integration of parallel 13 C-labeling experiments and in silico pathway analysis for enhanced production of ascomycin.Draft Genome Sequence of the Tacrolimus-Producing Bacterium Streptomyces tsukubaensis F601.Metabolic network model guided engineering ethylmalonyl-CoA pathway to improve ascomycin production in Streptomyces hygroscopicus var. ascomyceticus.Mutational biosynthesis of a FK506 analogue containing a non-natural starter unit.The calcineurin inhibitor Ascomicin interferes with the early stage of the epileptogenic process induced by Latrunculin A microperfusion in rat hippocampus.Enhancement of FK506 production by engineering secondary pathways of Streptomyces tsukubaensis and exogenous feeding strategies.Target genes of the Streptomyces tsukubaensis FkbN regulator include most of the tacrolimus biosynthesis genes, a phosphopantetheinyl transferase and other PKS genes.Unraveling Nutritional Regulation of Tacrolimus Biosynthesis in Streptomyces tsukubaensis through omic Approaches.
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Ascomycin and FK506: pharmacology and therapeutic potential as anticonvulsants and neuroprotectants.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on January 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Ascomycin and FK506: pharmacol ...... vulsants and neuroprotectants.
@en
Ascomycin and FK506: pharmacol ...... vulsants and neuroprotectants.
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type
label
Ascomycin and FK506: pharmacol ...... vulsants and neuroprotectants.
@en
Ascomycin and FK506: pharmacol ...... vulsants and neuroprotectants.
@nl
prefLabel
Ascomycin and FK506: pharmacol ...... vulsants and neuroprotectants.
@en
Ascomycin and FK506: pharmacol ...... vulsants and neuroprotectants.
@nl
P2860
P1476
Ascomycin and FK506: pharmacol ...... vulsants and neuroprotectants.
@en
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Germán Sierra-Marcuño
Germán Sierra-Paredes
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P356
10.1111/J.1755-5949.2008.00036.X
P577
2008-01-01T00:00:00Z