The core microprocessor component DiGeorge syndrome critical region 8 (DGCR8) is a nonspecific RNA-binding protein.
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The DGCR8 RNA-binding heme domain recognizes primary microRNAs by clamping the hairpinHelical defects in microRNA influence protein binding by TAR RNA binding proteinDesign of a bioactive small molecule that targets r(AUUCU) repeats in spinocerebellar ataxia 10A heterotrimer model of the complete Microprocessor complex revealed by single-molecule subunit countingDeformability in the cleavage site of primary microRNA is not sensed by the double-stranded RNA binding domains in the microprocessor component DGCR8The kinase ABL phosphorylates the microprocessor subunit DGCR8 to stimulate primary microRNA processing in response to DNA damage.Mini but mighty: microRNAs in the pathobiology of periodontal disease.DGCR8 Acts as an Adaptor for the Exosome Complex to Degrade Double-Stranded Structured RNAs.A Fleeting Glimpse Inside microRNA, Epigenetics, and Micropeptidomics.Binding by TRBP-dsRBD2 Does Not Induce Bending of Double-Stranded RNA.Atrial fibrillation and microRNAs.Down-expression of miR-154 suppresses tumourigenesis in CD133(+) glioblastoma stem cells.miR-154 suppresses colorectal cancer cell growth and motility by targeting TLR2.TDP-43 regulates the microprocessor complex activity during in vitro neuronal differentiation.RNA toxicity and foci formation in microsatellite expansion diseases.Engineering double-stranded RNA binding activity into the Drosha double-stranded RNA binding domain results in a loss of microRNA processing function.ssHMM: extracting intuitive sequence-structure motifs from high-throughput RNA-binding protein data.
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The core microprocessor component DiGeorge syndrome critical region 8 (DGCR8) is a nonspecific RNA-binding protein.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 26 July 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The core microprocessor compon ...... nspecific RNA-binding protein.
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The core microprocessor component DiGeorge syndrome critical region 8
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type
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The core microprocessor compon ...... nspecific RNA-binding protein.
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The core microprocessor component DiGeorge syndrome critical region 8
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prefLabel
The core microprocessor compon ...... nspecific RNA-binding protein.
@en
The core microprocessor component DiGeorge syndrome critical region 8
@nl
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The core microprocessor compon ...... nspecific RNA-binding protein.
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Braden M Roth
Daniella Ishimaru
Mirko Hennig
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26785-26799
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10.1074/JBC.M112.446880
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2013-07-26T00:00:00Z