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The SphKs/S1P/S1PR1 axis in immunity and cancer: more ore to be minedThe compartmentalization and translocation of the sphingosine kinases: mechanisms and functions in cell signaling and sphingolipid metabolismRole of the autotaxin-lysophosphatidate axis in cancer resistance to chemotherapy and radiotherapyInhibition of Sphingosine Kinase by Bovine Viral Diarrhea Virus NS3 Is Crucial for Efficient Viral Replication and CytopathogenesisTamoxifen regulation of sphingolipid metabolism--Therapeutic implicationsSphingosine-1-Phosphate Metabolism and Its Role in the Development of Inflammatory Bowel DiseaseSphingosine kinase inhibitors decrease viability and induce cell death in natural killer-large granular lymphocyte leukemia.Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells.High expression of SPHK1 in sacral chordoma and association with patients' poor prognosis.MicroRNA-338-3p suppresses cell proliferation and induces apoptosis of non-small-cell lung cancer by targeting sphingosine kinase 2.Identification of sphingosine kinase 1 (SphK1) as a primary target of icaritin in hepatocellular carcinoma cells.The expression of sphingosine kinase-1 in head and neck carcinomaSphingosine kinase 1 isoform-specific interactions in breast cancerSphingosine kinase-1 is required for toll mediated beta-defensin 2 induction in human oral keratinocytes.Twofer anti-vascular therapy targeting sphingosine-1-phosphate for breast cancer.Sphingosine analog fingolimod (FTY720) increases radiation sensitivity of human breast cancer cells in vitroEstradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2.Mammalian sphingosine kinase (SphK) isoenzymes and isoform expression: challenges for SphK as an oncotarget.Sphingosine kinase 1 in cancer.S1P metabolism in cancer and other pathological conditions.Loss of sphingosine kinase 1/S1P signaling impairs cell growth and survival of neurons and progenitor cells in the developing sensory gangliaAdvances in the management of peritoneal mesotheliomaLysophosphatidic acid stimulates gastric cancer cell proliferation via ERK1-dependent upregulation of sphingosine kinase 1 transcription.Epithelial cell extrusion requires the sphingosine-1-phosphate receptor 2 pathway.Genome wide analysis of acute myeloid leukemia reveal leukemia specific methylome and subtype specific hypomethylation of repeats.Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis.Characterization of phytochemicals and evaluation of anti-cancer potential of Blumea eriantha DC.An update on sphingosine-1-phosphate and other sphingolipid mediators.Sphingosine kinase 1 is required for mesothelioma cell proliferation: role of histone acetylation.Inhibition of SphK1 reduces radiation-induced migration and enhances sensitivity to cetuximab treatment by affecting the EGFR / SphK1 crosstalkSphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degenerationRegulation of cancer cell migration and invasion by sphingosine-1-phosphateThe role of sphingosine kinase-1 in EGFRvIII-regulated growth and survival of glioblastoma cellsSphingosine kinase 1 and cancer: a systematic review and meta-analysis.Effective inhibition of melanoma by BI-69A11 is mediated by dual targeting of the AKT and NF-κB pathwaysDevelopment of small-molecule inhibitors of sphingosine-1-phosphate signalingResveratrol induces apoptosis of leukemia cell line K562 by modulation of sphingosine kinase-1 pathway.Sphingolipid signaling and hematopoietic malignancies: to the rheostat and beyond.Targeting sphingosine kinase-1 to inhibit melanoma.TGFβ-Mediated induction of SphK1 as a potential determinant in human MDA-MB-231 breast cancer cell bone metastasis.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on August 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Targeting SphK1 as a new strategy against cancer.
@en
Targeting SphK1 as a new strategy against cancer.
@nl
type
label
Targeting SphK1 as a new strategy against cancer.
@en
Targeting SphK1 as a new strategy against cancer.
@nl
prefLabel
Targeting SphK1 as a new strategy against cancer.
@en
Targeting SphK1 as a new strategy against cancer.
@nl
P2093
P2860
P1433
P1476
Targeting SphK1 as a new strategy against cancer.
@en
P2093
Dmitri Kapitonov
Kazuaki Takabe
Sheldon Milstien
P2860
P304
P356
10.2174/138945008785132402
P577
2008-08-01T00:00:00Z