Identification of ligand-induced proteolytic cleavage and ectodomain shedding of VEGFR-1/FLT1 in leukemic cancer cells.
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The cellular response to vascular endothelial growth factors requires co-ordinated signal transduction, trafficking and proteolysisReceptor tyrosine kinases in the nucleusγ-Secretase inhibitors and modulators.A systems biology perspective on sVEGFR1: its biological function, pathogenic role and therapeutic use.Computational kinetic model of VEGF trapping by soluble VEGF receptor-1: effects of transendothelial and lymphatic macromolecular transport.Lymphoma cell VEGFR2 expression detected by immunohistochemistry predicts poor overall survival in diffuse large B cell lymphoma treated with immunochemotherapy (R-CHOP).Vascular Endothelial Growth Factor Receptor 1 morpholino increases graft survival in a murine penetrating keratoplasty model.Involvement of lysosomal degradation in VEGF-C-induced down-regulation of VEGFR-3.Soluble VEGFR-2: an antilymphangiogenic variant of VEGF receptors.Loss of presenilin 2 is associated with increased iPLA2 activity and lung tumor development.PEST motif serine and tyrosine phosphorylation controls vascular endothelial growth factor receptor 2 stability and downregulation.Aspirin inhibits expression of sFLT1 from human cytotrophoblasts induced by hypoxia, via cyclo-oxygenase 1.N-terminal cleavage and release of the ectodomain of Flt1 is mediated via ADAM10 and ADAM 17 and regulated by VEGFR2 and the Flt1 intracellular domainγ-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1.uPA and uPAR shRNA inhibit angiogenesis via enhanced secretion of SVEGFR1 independent of GM-CSF but dependent on TIMP-1 in endothelial and glioblastoma cells.Circulating Levels of sFlt1 Splice Variants as Predictive Markers for the Development of PreeclampsiaVascular endothelial growth factor receptor 1 morpholino decreases angiogenesis in a murine corneal suture model.Proteolytic cleavage, trafficking, and functions of nuclear receptor tyrosine kinases.The cytosolic domain of protein-tyrosine kinase 7 (PTK7), generated from sequential cleavage by a disintegrin and metalloprotease 17 (ADAM17) and γ-secretase, enhances cell proliferation and migration in colon cancer cellsCirculating ADAM17 Level Reflects Disease Activity in Proteinase-3 ANCA-Associated VasculitisSheddomeDB: the ectodomain shedding database for membrane-bound shed markers.β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment.Angiogenic factors in preeclampsia and related disordersCirculating multimarker profile of patients with symptomatic heart failure supports enhanced fibrotic degradation and decreased angiogenesis.Ectodomain cleavage of FLT1 regulates receptor activation and function and is not required for its downstream intracellular cleavage.The expression of presenilin 1 enhances carcinogenesis and metastasis in gastric cancer.Protein kinase C regulates FLT1 abundance and stimulates its cleavage in vascular endothelial cells with the release of a soluble PlGF/VEGF antagonistGlutaredoxin-1 up-regulation induces soluble vascular endothelial growth factor receptor 1, attenuating post-ischemia limb revascularizationc-Cbl inhibits angiogenesis and tumor growth by suppressing activation of PLCγ1Unlocking Doors without Keys: Activation of Src by Truncated C-terminal Intracellular Receptor Tyrosine Kinases Lacking Tyrosine Kinase Activity.Elevated soluble Flt1 inhibits endothelial repair in PR3-ANCA-associated vasculitis.The soluble VEGF receptor 1 and 2 expression in cerebral spinal fluid as an indicator for leukemia central nervous system metastasis.Assessing the Circulating Placental-Specific Anti-angiogenic Protein sFLT-1 e15a in Preeclampsia.Placental-specific sFLT-1: role in pre-eclamptic pathophysiology and its translational possibilities for clinical prediction and diagnosis.Genome-wide screen of gamma-secretase-mediated intramembrane cleavage of receptor tyrosine kinases.Molecular Pathways: Receptor Ectodomain Shedding in Treatment, Resistance, and Monitoring of Cancer.Soluble Flt-1 release response to heparin use: implications for dialysis patients?Heparin use during dialysis sessions induces an increase in the antiangiogenic factor soluble Flt1.Molecular Mechanisms of Preeclampsia.VEGF vascularization pathway in human intervertebral disc does not change during the disc degeneration process.
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Identification of ligand-induced proteolytic cleavage and ectodomain shedding of VEGFR-1/FLT1 in leukemic cancer cells.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 10 March 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Identification of ligand-induc ...... FLT1 in leukemic cancer cells.
@en
Identification of ligand-induc ...... FLT1 in leukemic cancer cells.
@nl
type
label
Identification of ligand-induc ...... FLT1 in leukemic cancer cells.
@en
Identification of ligand-induc ...... FLT1 in leukemic cancer cells.
@nl
prefLabel
Identification of ligand-induc ...... FLT1 in leukemic cancer cells.
@en
Identification of ligand-induc ...... FLT1 in leukemic cancer cells.
@nl
P2093
P2860
P1433
P1476
Identification of ligand-induc ...... FLT1 in leukemic cancer cells.
@en
P2093
Nader Rahimi
Rosana D Meyer
Todd E Golde
P2860
P304
P356
10.1158/0008-5472.CAN-08-2905
P407
P577
2009-03-10T00:00:00Z