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Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activityDirect interaction between Tks proteins and the N-terminal proline-rich region (PRR) of NoxA1 mediates Nox1-dependent ROS generationRole of redoximiRs in fibrogenesisNADPH oxidase inhibitors: a decade of discovery from Nox2ds to HTSTGF-β signaling in tissue fibrosis: redox controls, target genes and therapeutic opportunitiesTargeting the redox balance in inflammatory skin conditionsTetraspanin is required for generation of reactive oxygen species by the dual oxidase system in Caenorhabditis elegansAmyloid-β and proinflammatory cytokines utilize a prion protein-dependent pathway to activate NADPH oxidase and induce cofilin-actin rods in hippocampal neuronsMechanisms of chemical-induced innate immunity in allergic contact dermatitis.NOX enzymes as drug targetsTargeting vascular NADPH oxidase 1 blocks tumor angiogenesis through a PPARα mediated mechanismCigarette Smoke Impairs A2A Adenosine Receptor Mediated Wound Repair through Up-regulation of Duox-1 ExpressionNADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action.The role of oxidative stress in cerebral aneurysm formation and rupture.How Nox2-containing NADPH oxidase affects cortical circuits in the NMDA receptor antagonist model of schizophrenia.Reactive oxygen species mediate mitogenic growth factor signaling pathways in human leiomyoma smooth muscle cellsNADPH oxidases: a perspective on reactive oxygen species production in tumor biologyThe quest for selective nox inhibitors and therapeutics: challenges, triumphs and pitfallsEmerging evidence for the importance of phosphorylation in the regulation of NADPH oxidases.A novel and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cellsPeriarticular bone loss in antigen-induced arthritis.NADPH oxidase enzymes in skin fibrosis: molecular targets and therapeutic agentsHigh-throughput assays for superoxide and hydrogen peroxide: design of a screening workflow to identify inhibitors of NADPH oxidases.Increased glycation and oxidative damage to apolipoprotein B100 of LDL cholesterol in patients with type 2 diabetes and effect of metformin.Nox4 B-loop creates an interface between the transmembrane and dehydrogenase domains.Reactive oxygen species induce MMP12-dependent degradation of collagen 5 and fibronectin to promote the motility of human umbilical cord-derived mesenchymal stem cells.Gp91phox (NOX2) in classically activated microglia exacerbates traumatic brain injury.Substance P exacerbates dopaminergic neurodegeneration through neurokinin-1 receptor-independent activation of microglial NADPH oxidaseTargeting NOX enzymes in the central nervous system: therapeutic opportunities.Nox enzymes from fungus to fly to fish and what they tell us about Nox function in mammalsc-Src-mediated phosphorylation of NoxA1 and Tks4 induces the reactive oxygen species (ROS)-dependent formation of functional invadopodia in human colon cancer cells.Activation of microglia depends on Na+/H+ exchange-mediated H+ homeostasis.Advances in lupus genetics and epigeneticsProliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K/Akt-dependant manner.Oregonin from the Bark of Alnus japonica restrained ischemia-reperfusion-induced mesentery oxidative stress by inhibiting NADPH oxidase activation.Nox4: a hydrogen peroxide-generating oxygen sensor.Upstream regulators and downstream effectors of NADPH oxidases as novel therapeutic targets for diabetic kidney disease.Post-treatment with an ultra-low dose of NADPH oxidase inhibitor diphenyleneiodonium attenuates disease progression in multiple Parkinson's disease modelsNOX2-derived reactive oxygen species are crucial for CD29-induced pro-survival signalling in cardiomyocytesConstitutive NADPH oxidase 4 activity resides in the composition of the B-loop and the penultimate C terminus
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 29 May 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
NOX enzymes as novel targets for drug development.
@en
NOX enzymes as novel targets for drug development.
@nl
type
label
NOX enzymes as novel targets for drug development.
@en
NOX enzymes as novel targets for drug development.
@nl
prefLabel
NOX enzymes as novel targets for drug development.
@en
NOX enzymes as novel targets for drug development.
@nl
P2093
P2860
P1476
NOX enzymes as novel targets for drug development.
@en
P2093
J David Lambeth
Karl-Heinz Krause
Robert A Clark
P2860
P2888
P304
P356
10.1007/S00281-008-0123-6
P577
2008-05-29T00:00:00Z