Novel aspects of the molecular mechanisms controlling insulin secretion. - Wikidata - awgldk - TriplyDB

Novel aspects of the molecular mechanisms controlling insulin secretion.

Novel aspects of the molecular mechanisms controlling insulin secretion.

http://www.wikidata.org/entity/Q37176911

about

CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes Voltage-gated calcium channels Preferential release of newly synthesized insulin assessed by a multi-label reporter system using pancreatic β-cell line MIN6 Glucocorticoids differentially regulate the expression of CRFR1 and CRFR2α in MIN6 insulinoma cells and rodent islets Subplasmalemmal Ca(2+) measurements in mouse pancreatic beta cells support the existence of an amplifying effect of glucose on insulin secretion The secretory deficit in islets from db/db mice is mainly due to a loss of responding beta cells.Exocytosis mechanisms underlying insulin release and glucose uptake: conserved roles for Munc18c and syntaxin 4 Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/- mice Control of the intracellular redox state by glucose participates in the insulin secretion mechanism Lessons from models of pancreatic beta cells for engineering glucose-sensing cells Beta-cell specific deletion of Dicer1 leads to defective insulin secretion and diabetes mellitus.The N- and C-terminal domains of tomosyn play distinct roles in soluble N-ethylmaleimide-sensitive factor attachment protein receptor binding and fusion regulation Cell signalling in insulin secretion: the molecular targets of ATP, cAMP and sulfonylurea.Impairment of vesicular ATP release affects glucose metabolism and increases insulin sensitivity.High glucose predisposes gene expression and ERK phosphorylation to apoptosis and impaired glucose-stimulated insulin secretion via the cytoskeleton Cellular hypoxia of pancreatic beta-cells due to high levels of oxygen consumption for insulin secretion in vitro.Dynamics of insulin secretion and the clinical implications for obesity and diabetes Analysis of synaptic-like microvesicle exocytosis of B-cells using a live imaging technique.Calcium current inactivation rather than pool depletion explains reduced exocytotic rate with prolonged stimulation in insulin-secreting INS-1 832/13 cells.Islet cholesterol accumulation due to loss of ABCA1 leads to impaired exocytosis of insulin granules.Coupling of metabolic, second messenger pathways and insulin granule dynamics in pancreatic beta-cells: a computational analysis Imaging dynamic insulin release using a fluorescent zinc indicator for monitoring induced exocytotic release (ZIMIR).Sphingosine kinase 1 knockdown reduces insulin synthesis and secretion in a rat insulinoma cell line Statistical Frailty Modeling for Quantitative Analysis of Exocytotic Events Recorded by Live Cell Imaging: Rapid Release of Insulin-Containing Granules Is Impaired in Human Diabetic β-cells Corelease of dopamine and GABA by a retinal dopaminergic neuron A computational systems analysis of factors regulating α cell glucagon secretion.Disease, Models, Variants and Altered Pathways-Journeying RGD Through the Magnifying Glass.Forkhead box O1 promotes INS‑1 cell apoptosis by reducing the expression of CD24.Bulk-like endocytosis plays an important role in the recycling of insulin granules in pancreatic beta cells.Newcomer insulin secretory granules as a highly calcium-sensitive pool Exploring functional beta-cell heterogeneity in vivo using PSA-NCAM as a specific marker.The granular chloride channel ClC-3 is permissive for insulin secretion.The role of the transcription factor ETV5 in insulin exocytosis.Pancreatic beta-cell signaling: toward better understanding of diabetes and its treatment.L-type calcium channels and psychiatric disorders: A brief review.Signal integration at the level of ion channel and exocytotic function in pancreatic β-cells.Regulation of calcium in pancreatic α- and β-cells in health and disease.Reactive aldehydes--second messengers of free radicals in diabetes mellitus.Role of non-coding RNAs in pancreatic beta-cell development and physiology.

P2860

Q24298624-A1AF83AF-0301-4578-BF92-4AF60980D0EE Q24336126-CEB5948F-B004-4907-9244-5FB49BD55EB6 Q28242997-E15C3C1D-274E-4D5B-8F63-3B58CE57384C Q28484639-BB212BE1-ADE1-4B32-BCAC-AF64B380668F Q28579641-FA644CA4-BFFE-4168-9547-7AAAF024C94F Q29036821-9F9961D0-0948-4A8E-A3B7-58FDE7B61444 Q30580446-3A2F4F40-C312-4665-940D-02D1A0C0F139 Q33728169-5EF078E9-7F52-4892-867D-E5507A53194B Q33740266-EDCD4719-07D3-49B4-9E51-3B8EF994A729 Q34016498-E9F205A4-7012-4418-9A39-B2EB92A51960 Q34054232-E39CA00B-BFB9-49DD-AA35-C977D8F86547 Q34117281-D711F631-DB07-47AD-A21D-799F66E401F3 Q34170677-D579A935-CBA2-4D67-9426-45F5690CF4A0 Q34272586-D8AE5161-D28F-4E76-9978-F6F007C25EED Q34375659-4478EFF3-CEF3-4D43-B761-9355A77B4568 Q34425147-46071D9B-706A-47AE-A1C0-CC0D49620942 Q34752423-94471DB5-7145-4A18-801E-4C48B390B256 Q35015726-75126A37-A492-4806-B365-237EEEC0BBED Q35087718-1FC4994E-1C77-4C44-A3B3-3A372F6F0E94 Q35221742-6E53501E-398C-46FF-B195-EFD1FB21D320 Q35561092-220518AC-5A01-4B4E-B615-35FF04929881 Q35630344-DA39185E-C3DD-43CA-AC29-25FB695ABE19 Q35641202-53B24F3F-6F9C-40CF-B981-A2305F611C0E Q35885637-708187D8-0DFA-4290-B754-A0C88072EBB1 Q36209905-963E89E5-5366-4C4D-84F4-4F2141BF0AA7 Q36371328-F8134B84-5F4A-441F-BDC2-84909685CDEC Q36394674-05BADBEC-1FF7-41CA-BF3C-F22C72668BF6 Q36427543-DE30BE48-B2A8-4E0F-B177-3A44B899ED48 Q36722233-468026C8-4E4A-48D5-A4BA-6A2A5D0F8CB2 Q36922900-70435FD9-08AA-4FBD-B3B6-E05545E8DD8F Q37182979-552B61DB-B299-4397-940A-438C00DA3FD1 Q37184690-90AE67FA-7D20-4AD8-A665-49D3B2C58FB3 Q37423229-0BA8421C-08A6-42B9-9CFF-D888ADBC53B7 Q37626281-D58EDFC0-0EF9-4B53-AAFD-67CD2C32A192 Q37765396-C6BADE2C-899A-4987-8015-412966AB37A2 Q37795701-0F97E961-57C0-4F58-B05E-8359ACBE6D0C Q37936038-01C3750A-2A09-448B-B40D-2E8F841EF0A3 Q37969351-570BC7BC-3981-45A5-9455-3E4D57710925 Q38092186-55B0B293-297A-4DFA-9A95-2EA44A064002 Q38199221-7C1957AC-C953-4524-84A8-A77F083AF3F5

P2860

Novel aspects of the molecular mechanisms controlling insulin secretion.

http://www.wikidata.org/entity/Q37176911

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 29 May 2008

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Novel aspects of the molecular mechanisms controlling insulin secretion.

@en

Novel aspects of the molecular mechanisms controlling insulin secretion.

@nl

type

label

Novel aspects of the molecular mechanisms controlling insulin secretion.

@en

Novel aspects of the molecular mechanisms controlling insulin secretion.

@nl

prefLabel

Novel aspects of the molecular mechanisms controlling insulin secretion.

@en

Novel aspects of the molecular mechanisms controlling insulin secretion.

@nl

P1433

Q37176911-1C709332-7593-4269-AD65-E45FE03C9449

P1476

Q37176911-4350B998-864A-47A8-B43B-EF820AB0A65B

P2093

Q37176911-5043C5A9-AD57-4870-8D85-9B24B0AABEC2

Q37176911-65E7E4F6-0D61-4138-A21A-D13AC0BFF06D

Q37176911-D065820F-7812-445A-9E16-F2DC373D6612

Q37176911-EE0F3515-C6BF-4CA5-85B1-E414EF191F50

P2860

Q37176911-00EE6E9A-4342-40A6-B654-E81C6B516B88

Q37176911-05EF7CEF-42C6-42C7-BB1E-ECDA30AAA4CF

Q37176911-07660BE1-CECF-4821-B176-2A719580302F

Q37176911-0790FB85-03D9-42D9-944E-9AF22F6D17A5

Q37176911-0BEEA6CF-0FC1-44C7-BF11-6AF53C8958A9

Q37176911-1094108B-A374-427D-A956-9244092661A7

Q37176911-12E843F3-14F6-491B-AAB3-91CC96C0E1F4

Q37176911-15824B91-9F4D-4EF1-BADD-72052C8F7164

Q37176911-1C89B5D4-414D-48A2-A254-36D777BBD034

Q37176911-236EA5E1-131C-4B7F-8E12-97EA5FEB62D6

P304

Q37176911-D5F836A5-5AD3-4D7B-8767-151AB3B5522B

P31

Q37176911-214E932B-1713-4B8E-A641-13A631C52C92

P356

Q37176911-C0CA6111-D209-468A-BB96-C01F01CD3AB8

P407

Q37176911-5C907F21-F2B8-46FE-AD5D-DE12F2714EF3

P433

Q37176911-48AC9A62-4DEC-4D65-9D77-83953582A2EB

P478

Q37176911-D9ECDF23-7796-459E-A625-7FCAB089A723

P50

Q37176911-43CC835C-80EF-4A20-8932-671091153790

Q37176911-AF9079E4-C88E-4C95-AB3C-2A03B34B6710

P577

Q37176911-9D45A39D-A995-43D5-836F-DF83C218A028

P5875

Q37176911-A5E166C0-E2E0-4B97-830A-C9AE8E8D9853

P698

Q37176911-1C0BD3D2-5546-42EA-AFF2-F04C9EE0BA1A

P921

Q37176911-11E87F93-E97F-41F5-9117-DF6027CED59E

P932

Q37176911-2259BD20-D657-4642-A2A9-AE67C4E3C0C7

P356

JPHYSIOL.2008.155317

P1433

The Journal of Physiology

P1476

Novel aspects of the molecular mechanisms controlling insulin secretion.

@en

P2093

Fernando Abdulkader

http://www.w3.org/2001/XMLSchema#string

Juris Galvanovskis

http://www.w3.org/2001/XMLSchema#string

Matthias Braun

http://www.w3.org/2001/XMLSchema#string

Michael B Hoppa

http://www.w3.org/2001/XMLSchema#string

P2860

Granuphilin modulates the exocytosis of secretory granules through interaction with syntaxin 1a

Temporally resolved catecholamine spikes correspond to single vesicle release from individual chromaffin cells

Stimulation of NSF ATPase activity by alpha-SNAP is required for SNARE complex disassembly and exocytosis

Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice

Munc18-1 binds directly to the neuronal SNARE complex

Triggering and amplifying pathways of regulation of insulin secretion by glucose.

Insulin secretion by 'kiss-and-run' exocytosis in clonal pancreatic islet beta-cells.

Insulin secretion: a high-affinity Ca2+ sensor after all?

Impaired gene and protein expression of exocytotic soluble N-ethylmaleimide attachment protein receptor complex proteins in pancreatic islets of type 2 diabetic patients.

Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion.

P304

3313-3324

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1113/JPHYSIOL.2008.155317

http://www.w3.org/2001/XMLSchema#string

P407

P433

14

http://www.w3.org/2001/XMLSchema#string

P478

586

http://www.w3.org/2001/XMLSchema#string

P50

P577

2008-05-29T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

5340390

http://www.w3.org/2001/XMLSchema#string

P698

18511483

http://www.w3.org/2001/XMLSchema#string

P921

P932

2538808

http://www.w3.org/2001/XMLSchema#string