Boswellic acid blocks signal transducers and activators of transcription 3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase SHP-1. - Wikidata - awgldk - TriplyDB

Boswellic acid blocks signal transducers and activators of transcription 3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase SHP-1.

Boswellic acid blocks signal transducers and activators of transcription 3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase SHP-1.

http://www.wikidata.org/entity/Q37179677

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Protein tyrosine phosphatases, TC-PTP, SHP1, and SHP2, cooperate in rapid dephosphorylation of Stat3 in keratinocytes following UVB irradiation Therapeutic modulators of STAT signalling for human diseases Alteration of SHP-1/p-STAT3 Signaling: A Potential Target for Anticancer Therapy.Boswellic acid suppresses growth and metastasis of human pancreatic tumors in an orthotopic nude mouse model through modulation of multiple targets.TG101209, a novel JAK2 inhibitor, has significant in vitro activity in multiple myeloma and displays preferential cytotoxicity for CD45+ myeloma cells Retigeric acid B exhibits antitumor activity through suppression of nuclear factor-κB signaling in prostate cancer cells in vitro and in vivo.Acetyl-11-keto-β-boswellic acid suppresses invasion of pancreatic cancer cells through the downregulation of CXCR4 chemokine receptor expression.Prognostic significance of STAT3 and phosphorylated STAT3 in human soft tissue tumors - a clinicopathological analysis Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer.Identification of novel anti-inflammatory agents from Ayurvedic medicine for prevention of chronic diseases: "reverse pharmacology" and "bedside to bench" approach Specific dephosphorylation of Janus Kinase 2 by protein tyrosine phosphatases.Dihydroxypentamethoxyflavone down-regulates constitutive and inducible signal transducers and activators of transcription-3 through the induction of tyrosine phosphatase SHP-1 Boswellic acid induces epigenetic alterations by modulating DNA methylation in colorectal cancer cells.Boswellic acid exerts antitumor effects in colorectal cancer cells by modulating expression of the let-7 and miR-200 microRNA family Unifying mechanisms of action of the anticancer activities of triterpenoids and synthetic analogs.Sorafenib and its derivative SC-49 sensitize hepatocellular carcinoma cells to CS-1008, a humanized anti-TNFRSF10B (DR5) antibody.Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling.Decreased STAT3 Phosphorylation Mediates Cell Swelling in Ammonia-Treated Astrocyte Cultures.Novel sorafenib analogues induce apoptosis through SHP-1 dependent STAT3 inactivation in human breast cancer cells.Luteolin selectively kills STAT3 highly activated gastric cancer cells through enhancing the binding of STAT3 to SHP-1.Cancer Prevention and Therapy: Integrating Traditional Korean Medicine Into Modern Cancer Care.Implication of protein tyrosine phosphatase SHP-1 in cancer-related signaling pathways.Role of angiogenic factors of herbal origin in regulation of molecular pathways that control tumor angiogenesis.Therapeutic potential of boswellic acids: a patent review (1990-2015).Obatoclax analog SC-2001 inhibits STAT3 phosphorylation through enhancing SHP-1 expression and induces apoptosis in human breast cancer cells.Boswellic acid disables signal transduction of IL-6-STAT-3 in Ehrlich ascites tumor bearing irradiated mice.Inhibition of microsomal prostaglandin E2 synthase-1 as a molecular basis for the anti-inflammatory actions of boswellic acids from frankincense.Boswellic acid inhibits expression of acid sphingomyelinase in intestinal cells.Curcumin analogue, A13, exhibits anti-leukemia effect via inhibiting STAT3.Icariside II overcomes TRAIL resistance of melanoma cells through ROS-mediated downregulation of STAT3/cFLIP signaling.Mediators of inflammation-induced bone damage in arthritis and their control by herbal products The roles of signal transducer and activator of transcription factor 3 in tumor angiogenesis.Boswellic acids reduce Th17 differentiation via blockade of IL-1β-mediated IRAK1 signaling.Transcriptomic Profiling of MDA-MB-231 Cells Exposed to Boswellia Serrata and 3-O-Acetyl-B-Boswellic Acid; ER/UPR Mediated Programmed Cell Death.Protein tyrosine phosphatase 1B is a regulator of the interleukin-10-induced transcriptional program in macrophages.CD8+ T cells mediate the antitumor activity of frankincense and myrrh in hepatocellular carcinoma.Magnolol: A Neolignan from the Magnolia Family for the Prevention and Treatment of Cancer Googling the Guggul (Commiphora and Boswellia) for Prevention of Chronic Diseases Retraction: Boswellic Acid Blocks Signal Transducers and Activators of Transcription 3 Signaling, Proliferation, and Survival of Multiple Myeloma via the Protein Tyrosine Phosphatase SHP-1

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Boswellic acid blocks signal transducers and activators of transcription 3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase SHP-1.

http://www.wikidata.org/entity/Q37179677

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on January 2009

@en

vedecký článok

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vetenskaplig artikel

@sv

videnskabelig artikel

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vědecký článek

@cs

name

Boswellic acid blocks signal t ...... in tyrosine phosphatase SHP-1.

@en

Boswellic acid blocks signal t ...... in tyrosine phosphatase SHP-1.

@nl

type

label

Boswellic acid blocks signal t ...... in tyrosine phosphatase SHP-1.

@en

Boswellic acid blocks signal t ...... in tyrosine phosphatase SHP-1.

@nl

prefLabel

Boswellic acid blocks signal t ...... in tyrosine phosphatase SHP-1.

@en

Boswellic acid blocks signal t ...... in tyrosine phosphatase SHP-1.

@nl

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1541-7786.MCR-08-0154

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Molecular Cancer Research

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Boswellic acid blocks signal t ...... in tyrosine phosphatase SHP-1.

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Ajaikumar B Kunnumakkara

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Asha S Nair

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Bharat B Aggarwal

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Bokyung Sung

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Manoj K Pandey

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P2860

CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling

STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation

The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation

Signal transducers and activators of transcription 3 (STAT3) inhibits transcription of the inducible nitric oxide synthase gene by interacting with nuclear factor kappaB

Protein-tyrosine phosphatase PTPepsilon C inhibits Jak-STAT signaling and differentiation induced by interleukin-6 and leukemia inhibitory factor in M1 leukemia cells

Involvement of tyrosine phosphatase PTP1D in the inhibition of interleukin-6-induced Stat3 signaling by alpha-thrombin

Boswellic acids trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells

Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solution

Mechanisms underlying the anti-inflammatory actions of boswellic acid derivatives in experimental colitis

Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression

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118-128

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scholarly article

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10.1158/1541-7786.MCR-08-0154

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1

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7

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2009-01-01T00:00:00Z

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23791488

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19147543

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2677182

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