Role of the region 23-28 in Abeta fibril formation: insights from simulations of the monomers and dimers of Alzheimer's peptides Abeta40 and Abeta42.
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Dimer formation enhances structural differences between amyloid β-protein (1-40) and (1-42): an explicit-solvent molecular dynamics studyStructural Conversion of Aβ17-42 Peptides from Disordered Oligomers to U-Shape Protofilaments via Multiple Kinetic PathwaysA multiscale approach to characterize the early aggregation steps of the amyloid-forming peptide GNNQQNY from the yeast prion sup-35The conformational stability of nonfibrillar amyloid-β peptide oligomers critically depends on the C-terminal peptide length.Flexibility and binding affinity in protein-ligand, protein-protein and multi-component protein interactions: limitations of current computational approaches.Probing the effect of amino-terminal truncation for Abeta1-40 peptides.Molecular dynamics simulations of anti-aggregation effect of ibuprofen.Globular state in the oligomers formed by Abeta peptides.Polymorphism in Alzheimer Abeta amyloid organization reflects conformational selection in a rugged energy landscape.Hollow core of Alzheimer's Abeta42 amyloid observed by cryoEM is relevant at physiological pH.Amyloid peptide Aβ40 inhibits aggregation of Aβ42: evidence from molecular dynamics simulations.Replica exchange molecular dynamics of the thermodynamics of fibril growth of Alzheimer's Aβ42 peptide.Interpeptide interactions induce helix to strand structural transition in Abeta peptidesDynamics of metastable β-hairpin structures in the folding nucleus of amyloid β-protein.Differences in β-strand populations of monomeric Aβ40 and Aβ42.Mechanism of amyloid β-protein dimerization determined using single-molecule AFM force spectroscopy.Probing energetics of Abeta fibril elongation by molecular dynamics simulations.Polymorphism of Alzheimer's Abeta17-42 (p3) oligomers: the importance of the turn location and its conformationSide chain interactions can impede amyloid fibril growth: replica exchange simulations of Abeta peptide mutant.Internal and environmental effects on folding and dimerization of the Alzheimer's β amyloid peptide.Small molecule inhibitors of amyloid β peptide aggregation as a potential therapeutic strategy for Alzheimer's disease.The role of molecular simulations in the development of inhibitors of amyloid β-peptide aggregation for the treatment of Alzheimer's diseaseBeta-amyloid oligomers: recent developments.Perspectives on Inhibiting β-Amyloid Aggregation through Structure-Based Drug Design.A kinetic approach to the sequence-aggregation relationship in disease-related protein assemblyEffects of Zn2+ binding on the structural and dynamic properties of amyloid β peptide associated with Alzheimer's disease: Asp1 or Glu11?Atomic and dynamic insights into the beneficial effect of the 1,4-naphthoquinon-2-yl-L-tryptophan inhibitor on Alzheimer's Aβ1-42 dimer in terms of aggregation and toxicity.Probing Medin Monomer Structure and its Amyloid Nucleation Using 13C-Direct Detection NMR in Combination with Structural BioinformaticsEffect of the Tottori familial disease mutation (D7N) on the monomers and dimers of Aβ40 and Aβ42.Characterization of the polymorphic states of copper(II)-bound Aβ(1-16) peptides by computational simulations.Effect of a Paramagnetic Spin Label on the Intrinsically Disordered Peptide Ensemble of Amyloid-β.NSAIDs as potential treatment option for preventing amyloid β toxicity in Alzheimer's disease: an investigation by docking, molecular dynamics, and DFT studies.Study on the inter- and intra-peptide salt-bridge mechanism of Aβ23-28 oligomer interaction with small molecules: QM/MM method.Early oligomerization stages for the non-amyloid component of α-synuclein amyloidStructural, thermodynamical, and dynamical properties of oligomers formed by the amyloid NNQQ peptide: Insights from coarse-grained simulations
P2860
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P2860
Role of the region 23-28 in Abeta fibril formation: insights from simulations of the monomers and dimers of Alzheimer's peptides Abeta40 and Abeta42.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
@tr
scientific article published on June 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Role of the region 23-28 in Ab ...... peptides Abeta40 and Abeta42.
@en
Role of the region 23-28 in Ab ...... peptides Abeta40 and Abeta42.
@nl
type
label
Role of the region 23-28 in Ab ...... peptides Abeta40 and Abeta42.
@en
Role of the region 23-28 in Ab ...... peptides Abeta40 and Abeta42.
@nl
prefLabel
Role of the region 23-28 in Ab ...... peptides Abeta40 and Abeta42.
@en
Role of the region 23-28 in Ab ...... peptides Abeta40 and Abeta42.
@nl
P1476
Role of the region 23-28 in Ab ...... peptides Abeta40 and Abeta42.
@en
P2093
Philippe Derreumaux
P304
P356
10.2174/156720508784533330
P577
2008-06-01T00:00:00Z