Design and validation of specific inhibitors of 17beta-hydroxysteroid dehydrogenases for therapeutic application in breast and prostate cancer, and in endometriosis.
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Insights in 17beta-HSD1 enzyme kinetics and ligand binding by dynamic motion investigationStructure and Mechanism of Human UDP-glucose 6-DehydrogenaseSpecies used for drug testing reveal different inhibition susceptibility for 17beta-hydroxysteroid dehydrogenase type 1Structural basis for species specific inhibition of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1): computational study and biological validationHydroxybenzothiazoles as new nonsteroidal inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1)Investigation of testosterone, androstenone, and estradiol metabolism in HepG2 cells and primary culture pig hepatocytes and their effects on 17βHSD7 gene expressionThe Role of Androgens in Normal and Malignant Breast Tissue.17β-Hydroxysteroid dehydrogenase type 14 is a predictive marker for tamoxifen response in oestrogen receptor positive breast cancerThe stimulation of HSD17B7 expression by estradiol provides a powerful feed-forward mechanism for estradiol biosynthesis in breast cancer cells.Human hydroxysteroid dehydrogenases and pre-receptor regulation: insights into inhibitor design and evaluation.New hormonal therapies for castration-resistant prostate cancer.The effects of the standardized extracts of Ginkgo biloba on steroidogenesis pathways and aromatase activity in H295R human adrenocortical carcinoma cells.Expression of estrogenicity genes in a lineage cell culture model of human breast cancer progression.17beta-Hydroxysteroid dehydrogenase inhibitors: a patent review.Regulation of 17β-hydroxysteroid dehydrogenases in cancer: regulating steroid receptor at pre-receptor stage.Oestrogen and colorectal cancer: mechanisms and controversies.Crucial Role of 3-Bromoethyl in Removing the Estrogenic Activity of 17β-HSD1 Inhibitor 16β-(m-Carbamoylbenzyl)estradiol.A role for the dehydrogenase DHRS7 (SDR34C1) in prostate cancer.Transcriptional regulation of type 11 17β-hydroxysteroid dehydrogenase expression in prostate cancer cellsSynthesis of novel 13α-estrone derivatives by Sonogashira coupling as potential 17β-HSD1 inhibitors.Molecular cloning and expression of 17β-hydroxysteroid dehydrogenase type 2 gene in Hu sheep.A validated and rapid high-performance liquid chromatography method for the quantification of conversion of radio-labelled sex steroids.Synthesis and Biological Evaluation of Triazolyl 13α-Estrone-Nucleoside Bioconjugates.Comparative investigation of the in vitro inhibitory potencies of 13-epimeric estrones and D-secoestrones towards 17β-hydroxysteroid dehydrogenase type 1.Maternal lead exposure during lactation persistently impairs testicular development and steroidogenesis in male offspring.Inhibition of dihydrotestosterone synthesis in prostate cancer by combined frontdoor and backdoor pathway blockade.AKR1C enzymes sustain therapy resistance in paediatric T-ALL.Design and synthesis of substrate mimetics based on an indole scaffold: potential inhibitors of 17β-HSD type 1.
P2860
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P2860
Design and validation of specific inhibitors of 17beta-hydroxysteroid dehydrogenases for therapeutic application in breast and prostate cancer, and in endometriosis.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 09 June 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Design and validation of speci ...... cancer, and in endometriosis.
@en
Design and validation of speci ...... cancer, and in endometriosis.
@nl
type
label
Design and validation of speci ...... cancer, and in endometriosis.
@en
Design and validation of speci ...... cancer, and in endometriosis.
@nl
prefLabel
Design and validation of speci ...... cancer, and in endometriosis.
@en
Design and validation of speci ...... cancer, and in endometriosis.
@nl
P2093
P356
P1476
Design and validation of speci ...... cancer, and in endometriosis.
@en
P2093
Atul Purohit
Helena J Tutill
Joanna M Day
Michael J Reed
P304
P356
10.1677/ERC-08-0042
P577
2008-06-09T00:00:00Z