Defects of Vps15 in skeletal muscles lead to autophagic vacuolar myopathy and lysosomal disease
about
Skeletal muscle autophagy: a new metabolic regulatorDisrupted autophagy undermines skeletal muscle adaptation and integrityX-linked myopathy with excessive autophagy: a failure of self-eatingRegulation of mammalian autophagy by class II and III PI 3-kinases through PI3P synthesisA mutation in VPS15 (PIK3R4) causes a ciliopathy and affects IFT20 release from the cis-GolgiClass III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling.Exercise-induced skeletal muscle remodeling and metabolic adaptation: redox signaling and role of autophagy.CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers.Rag GTPases are cardioprotective by regulating lysosomal function.Lysosomal two-pore channel subtype 2 (TPC2) regulates skeletal muscle autophagic signaling.Vps15 is required for stress induced and developmentally triggered autophagy and salivary gland protein secretion in Drosophila.Symmorphosis through dietary regulation: a combinatorial role for proteolysis, autophagy and protein synthesis in normalising muscle metabolism and function of hypertrophic mice after acute starvation.Maintenance of glia in the optic lamina is mediated by EGFR signaling by photoreceptors in adult Drosophila.Drosophila mitochondrial topoisomerase III alpha affects the aging process via maintenance of mitochondrial function and genome integrity.Molecular regulation of autophagy and its implications for metabolic diseases.Autophagy regulation by nutrient signaling.AMPK activation of muscle autophagy prevents fasting-induced hypoglycemia and myopathy during agingClasses of phosphoinositide 3-kinases at a glance."Get the Balance Right": Pathological Significance of Autophagy Perturbation in Neuromuscular DisordersAutophagy dysregulation in Danon disease.Protein breakdown in muscle wasting: role of autophagy-lysosome and ubiquitin-proteasomePhosphoinositide 3-kinases as accelerators and brakes of autophagy.Skeletal muscle, autophagy, and physical activity: the ménage à trois of metabolic regulation in health and disease.Danon disease: a phenotypic expression of LAMP-2 deficiency.Conditional knockout of pik3c3 causes a murine muscular dystrophy.p62/SQSTM1 but not LC3 is accumulated in sarcopenic muscle of miceAtg6/UVRAG/Vps34-containing lipid kinase complex is required for receptor downregulation through endolysosomal degradation and epithelial polarity during Drosophila wing development.Mitophagy in maintaining skeletal muscle mitochondrial proteostasis and metabolic health with ageing.Mutations in the X-linked ATP6AP2 cause a glycosylation disorder with autophagic defects.Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism.Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans.Regulation of Exercise-Induced Autophagy in Skeletal Muscle.AMPK in skeletal muscle function and metabolism.A Molecular Perspective of Mammalian Autophagosome Biogenesis.Dying myofibers in elderly mouse skeletal muscles are characterized by the appearance of dystrophin-encircled vacuoles.Exercise prevents impaired autophagy and proteostasis in a model of neurogenic myopathy
P2860
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P2860
Defects of Vps15 in skeletal muscles lead to autophagic vacuolar myopathy and lysosomal disease
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 30 April 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Defects of Vps15 in skeletal m ...... myopathy and lysosomal disease
@en
Defects of Vps15 in skeletal m ...... yopathy and lysosomal disease.
@nl
type
label
Defects of Vps15 in skeletal m ...... myopathy and lysosomal disease
@en
Defects of Vps15 in skeletal m ...... yopathy and lysosomal disease.
@nl
prefLabel
Defects of Vps15 in skeletal m ...... myopathy and lysosomal disease
@en
Defects of Vps15 in skeletal m ...... yopathy and lysosomal disease.
@nl
P2093
P2860
P356
P1476
Defects of Vps15 in skeletal m ...... myopathy and lysosomal disease
@en
P2093
Amelie Mueller
Bert Blaauw
Catherine Caillaud
Cecilia Paolini
Feliciano Protasi
Ganna Panasyuk
Ichizo Nishino
Ivan Nemazanyy
Kun-Liang Guan
Marco Sandri
P2860
P304
P356
10.1002/EMMM.201202057
P577
2013-04-30T00:00:00Z