Drug-target interactions: only the first step in the commitment to a programmed cell death?
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Genome-scale screening of drug-target associations relevant to Ki using a chemogenomics approachCitrus flavone tangeretin inhibits leukaemic HL-60 cell growth partially through induction of apoptosis with less cytotoxicity on normal lymphocytesExpression of apoptosis-related markers and clinical outcome in patients with advanced colorectal cancerDamage-induced Bax N-terminal change, translocation to mitochondria and formation of Bax dimers/complexes occur regardless of cell fate.5-Fluorouracil induces apoptosis in human colon cancer cell lines with modulation of Bcl-2 family proteinsDoes antigen masking by ubiquitin chains protect from the development of autoimmune diseases?Damage-induced apoptosis in intestinal epithelia from bcl-2-null and bax-null mice: investigations of the mechanistic determinants of epithelial apoptosis in vivoExpression of kinase-defective mutants of c-Src in human metastatic colon cancer cells decreases Bcl-xL and increases oxaliplatin- and Fas-induced apoptosis.Nitric oxide disrupts H2O2-dependent activation of nuclear factor kappa B. Role in sensitization of human tumor cells to tumor necrosis factor-alpha -induced cytotoxicity.Resistance to induced apoptosis in the human neuroblastoma cell line SK-N-SH in relation to neuronal differentiation. Role of Bcl-2 protein family.Apoptotic cell death triggered by camptothecin or teniposide. The cell cycle specificity and effects of ionizing radiation.Features of apoptotic cells measured by flow cytometry.Apoptosis and its clinical significance for bladder cancer therapy.Current concepts in gastrointestinal photodynamic therapy.In vivo near-infrared fluorescence imaging of apoptosis using histone H1-targeting peptide probe after anti-cancer treatment with cisplatin and cetuximab for early decision on tumor responseGeldanamycin attenuates 3‑nitropropionic acid‑induced apoptosis and JNK activation through the expression of HSP 70 in striatal cells.Apoptosis in cancer.MEK kinase 1, a substrate for DEVD-directed caspases, is involved in genotoxin-induced apoptosis.Ubiquitin-proteasome system and increased sensitivity of B-CLL lymphocytes to apoptotic death activation.Complexes of gallium(III) and other metal ions and their potential in the treatment of neoplasia.Molecular aspects of hepatic carcinogenesis.Predictive and prognostic markers for invasive breast cancer.[18F]- and [11C]-labeled N-benzyl-isatin sulfonamide analogues as PET tracers for apoptosis: synthesis, radiolabeling mechanism, and in vivo imaging study of apoptosis in Fas-treated mice using [11C]WC-98.Synthesis and evaluation of isatin analogs as caspase-3 inhibitors: introduction of a hydrophilic group increases potency in a whole cell assayPrediction of individual response to anticancer therapy: historical and future perspectivesEupatorin-induced cell death in human leukemia cells is dependent on caspases and activates the mitogen-activated protein kinase pathway.Time trends in accuracy of classification of testicular tumours, with clinical and epidemiological implications.Expression of the cell cycle inhibitor p27KIP1 is a new prognostic marker associated with survival in epithelial ovarian tumors.Demonstration of extensive chromatin cleavage in transplanted Morris hepatoma 7777 tissue: apoptosis or necrosis?The role of apoptosis in cell killing by cisplatin: a flow cytometric study.Roles of NF-kappaB and bcl-2 in two differential modes of cell death of mouse cortical collecting duct cells.Antisense oligonucleotides in the treatment of bladder cancer.Enhancement of drug sensitivity of human malignancies by epidermal growth factor.Apoptotic and non-apoptotic cell death induced by cis and trans analogues of a novel ammine(cyclohexylamine)dihydroxodichloroplatinum(IV) complex.Anti-proliferative activity and mechanism of action of titanocene dichloride.Effect of preoperative regional artery chemotherapy on proliferation and apoptosis of gastric carcinoma cellsInterleukin 7-dependent B lymphocyte precursor cells are ultrasensitive to apoptosis.Recent advances in targeting regulators of apoptosis in cancer cells for therapeutic gain.Human chromosome 3 mediates growth arrest and suppression of apoptosis in microcell hybrids.Role of the human heat shock protein hsp70 in protection against stress-induced apoptosis.
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Drug-target interactions: only the first step in the commitment to a programmed cell death?
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on July 1991
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Drug-target interactions: only ...... nt to a programmed cell death?
@en
Drug-target interactions: only ...... nt to a programmed cell death?
@nl
type
label
Drug-target interactions: only ...... nt to a programmed cell death?
@en
Drug-target interactions: only ...... nt to a programmed cell death?
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prefLabel
Drug-target interactions: only ...... nt to a programmed cell death?
@en
Drug-target interactions: only ...... nt to a programmed cell death?
@nl
P2860
P356
P1476
Drug-target interactions: only ...... nt to a programmed cell death?
@en
P2093
P2860
P2888
P304
P356
10.1038/BJC.1991.269
P407
P577
1991-07-01T00:00:00Z
P5875
P6179
1047102705