Chemical modifications of antisense morpholino oligomers enhance their efficacy against Ebola virus infection
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Animal models for Ebola and Marburg virus infectionsEmerging targets and novel approaches to Ebola virus prophylaxis and treatmentMonitoring of Ebola Virus Makona Evolution through Establishment of Advanced Genomic Capability in LiberiaPre-symptomatic diagnosis and treatment of filovirus diseasesMouse models for filovirus infectionsDelayed Time-to-Treatment of an Antisense Morpholino Oligomer Is Effective against Lethal Marburg Virus Infection in Cynomolgus MacaquesTargeting mRNA for the treatment of facioscapulohumeral muscular dystrophyBroad-spectrum agents for flaviviral infections: dengue, Zika and beyondCell penetrating peptides in the delivery of biopharmaceuticals.Evaluation of the potential impact of Ebola virus genomic drift on the efficacy of sequence-based candidate therapeutics.A single phosphorodiamidate morpholino oligomer targeting VP24 protects rhesus monkeys against lethal Ebola virus infectionA limited structural modification results in a significantly more efficacious diazachrysene-based filovirus inhibitorPotential vaccines and post-exposure treatments for filovirus infections.Discovery and early development of AVI-7537 and AVI-7288 for the treatment of Ebola virus and Marburg virus infections.Use of the Syrian hamster as a new model of ebola virus disease and other viral hemorrhagic fevers.Development of novel bioanalytical methods to determine the effective concentrations of phosphorodiamidate morpholino oligomers in tissues and cells.Morpholino treatment improves muscle function and pathology of Pitx1 transgenic mice.Developments in antivirals against influenza, smallpox and hemorrhagic fever viruses.Filovirus hemorrhagic fever outbreak case management: a review of current and future treatment options.Influence of diverse chemical modifications on the ADME characteristics and toxicology of antisense oligonucleotides.Oligonucleotide conjugates for therapeutic applications.Antitumor effects of EGFR antisense guanidine-based peptide nucleic acids in cancer models.Development of experimental and early investigational drugs for the treatment of Ebola virus infections.Nucleic acid-based drugs against emerging zoonotic viruses.Antisense antimicrobial therapeuticsCell-Penetrating Peptides for Antiviral Drug Development.Therapeutics Against Filovirus Infection.Nonhuman primates as models for the discovery and development of ebolavirus therapeutics.Depleting regulatory T cells with arginine-rich, cell-penetrating, peptide-conjugated morpholino oligomer targeting FOXP3 inhibits regulatory T-cell function.Antisense Phosphorodiamidate Morpholino Oligomers as Novel Antiviral Compounds.
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P2860
Chemical modifications of antisense morpholino oligomers enhance their efficacy against Ebola virus infection
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 17 February 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Chemical modifications of anti ...... against Ebola virus infection
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Chemical modifications of anti ...... against Ebola virus infection.
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type
label
Chemical modifications of anti ...... against Ebola virus infection
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Chemical modifications of anti ...... against Ebola virus infection.
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prefLabel
Chemical modifications of anti ...... against Ebola virus infection
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Chemical modifications of anti ...... against Ebola virus infection.
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P2093
P2860
P356
P1476
Chemical modifications of anti ...... against Ebola virus infection
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P2093
Candace Lovejoy
Dana L Swenson
Dwight D Weller
Gordon Ruthel
Hong M Moulton
Jed N Hassinger
Kelly L Warfield
Patrick L Iversen
Robert E Blouch
Travis K Warren
P2860
P304
P356
10.1128/AAC.00936-08
P407
P50
P577
2009-02-17T00:00:00Z