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Inherited BCL10 deficiency impairs hematopoietic and nonhematopoietic immunityCOP9 signalosome controls the Carma1-Bcl10-Malt1 complex upon T-cell stimulationCutting edge: the "death" adaptor CRADD/RAIDD targets BCL10 and suppresses agonist-induced cytokine expression in T lymphocytesAPI2-MALT1 oncoprotein promotes lymphomagenesis via unique program of substrate ubiquitination and proteolysisCrystal structure of the mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) paracaspase regionStructural analysis of phenothiazine derivatives as allosteric inhibitors of the MALT1 paracaspaseComparative genomic analysis of the zebra finch degradome provides new insights into evolution of proteases in birds and mammalsSignaling to NF-kappaB: regulation by ubiquitination.The CARMA3-Bcl10-MALT1 signalosome promotes angiotensin II-dependent vascular inflammation and atherogenesis.Antigen receptor signaling to NF-kappaB via CARMA1, BCL10, and MALT1.Molecular basis of lysophosphatidic acid-induced NF-κB activationCleavage of NIK by the API2-MALT1 fusion oncoprotein leads to noncanonical NF-kappaB activationMalt1-dependent RelB cleavage promotes canonical NF-kappaB activation in lymphocytes and lymphoma cell lines.MALT1 auto-proteolysis is essential for NF-κB-dependent gene transcription in activated lymphocytes.Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation.Conversion of the LIMA1 tumour suppressor into an oncogenic LMO-like protein by API2-MALT1 in MALT lymphoma.Characteristics of CARMA1-BCL10-MALT1-A20-NF-κB expression in T cell-acute lymphocytic leukemiaAntigen-independent signalosome of CARMA1, PKCθ, and TNF receptor-associated factor 2 (TRAF2) determines NF-κB signaling in T cellsShigella IpaH0722 E3 ubiquitin ligase effector targets TRAF2 to inhibit PKC-NF-κB activity in invaded epithelial cells.Malt1 protease inactivation efficiently dampens immune responses but causes spontaneous autoimmunity.Monoubiquitination and activity of the paracaspase MALT1 requires glutamate 549 in the dimerization interfaceThe E3 ubiquitin ligase mind bomb-2 (MIB2) protein controls B-cell CLL/lymphoma 10 (BCL10)-dependent NF-κB activation.MALT1 Protease Activity Is Required for Innate and Adaptive Immune Responses.Insights into the Molecular Pathogenesis of Activated B-Cell-like Diffuse Large B-Cell Lymphoma and Its Therapeutic Implications.Genomic analysis of marginal zone and lymphoplasmacytic lymphomas identified common and disease-specific abnormalities.Differential expression of T cell-related genes in AMI and SA stages of coronary artery disease.MALT1 is required for EGFR-induced NF-κB activation and contributes to EGFR-driven lung cancer progressionA20: linking a complex regulator of ubiquitylation to immunity and human diseaseChanges in the MALT1-A20-NF-κB expression pattern may be related to T cell dysfunction in AML.Genetic errors of the human caspase recruitment domain-B-cell lymphoma 10-mucosa-associated lymphoid tissue lymphoma-translocation gene 1 (CBM) complex: Molecular, immunologic, and clinical heterogeneity.A homozygous mucosa-associated lymphoid tissue 1 (MALT1) mutation in a family with combined immunodeficiency.Sufficient production of geranylgeraniol is required to maintain endotoxin tolerance in macrophages.Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma.Abnormal expression of A20 and its regulated genes in peripheral blood from patients with lymphomas.Programmed cell death in the plant immune systemProtease activity of the API2-MALT1 fusion oncoprotein in MALT lymphoma development and treatment.L-CBM signaling in lymphocyte development and functionThe versatile roles of CARDs in regulating apoptosis, inflammation, and NF-κB signaling.MALT1--a universal soldier: multiple strategies to ensure NF-κB activation and target gene expression.MALT1 Inhibition of Oral Carcinoma Cell Invasion and ERK/MAPK Activation.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on July 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Multifunctional roles for MALT1 in T-cell activation.
@en
Multifunctional roles for MALT1 in T-cell activation.
@nl
type
label
Multifunctional roles for MALT1 in T-cell activation.
@en
Multifunctional roles for MALT1 in T-cell activation.
@nl
prefLabel
Multifunctional roles for MALT1 in T-cell activation.
@en
Multifunctional roles for MALT1 in T-cell activation.
@nl
P356
P1476
Multifunctional roles for MALT1 in T-cell activation
@en
P2093
Margot Thome
P304
P356
10.1038/NRI2338
P50
P577
2008-07-01T00:00:00Z