Partial blockage of sterol biosynthesis with a squalene synthase inhibitor in early postnatal Niemann-Pick type C npcnih null mice brains reduces neuronal cholesterol accumulation, abrogates astrogliosis, but may inhibit myelin maturation.
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Cholesterol pathways affected by small molecules that decrease sterol levels in Niemann-Pick type C mutant cells.Abnormal gene expression in cerebellum of Npc1-/- mice during postnatal development.Inhibiting ACAT1/SOAT1 in microglia stimulates autophagy-mediated lysosomal proteolysis and increases Aβ1-42 clearanceNiemann-Pick type C pathogenesis and treatment: from statins to sugars.Cholesterol in Niemann-Pick Type C disease.Defective cholesterol trafficking in Niemann-Pick C-deficient cells.Treatment of Niemann--pick type C disease by histone deacetylase inhibitors.Modeling cholesterol metabolism by gene expression profiling in the hippocampus.Aberrant activation of Cdc2/cyclin B1 is involved in initiation of cytoskeletal pathology in murine Niemann-Pick disease type C.
P2860
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P2860
Partial blockage of sterol biosynthesis with a squalene synthase inhibitor in early postnatal Niemann-Pick type C npcnih null mice brains reduces neuronal cholesterol accumulation, abrogates astrogliosis, but may inhibit myelin maturation.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 12 September 2007
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Partial blockage of sterol bio ...... may inhibit myelin maturation.
@en
Partial blockage of sterol bio ...... may inhibit myelin maturation.
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type
label
Partial blockage of sterol bio ...... may inhibit myelin maturation.
@en
Partial blockage of sterol bio ...... may inhibit myelin maturation.
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prefLabel
Partial blockage of sterol bio ...... may inhibit myelin maturation.
@en
Partial blockage of sterol bio ...... may inhibit myelin maturation.
@nl
P2093
P2860
P1476
Partial blockage of sterol bio ...... may inhibit myelin maturation.
@en
P2093
Catherine C Y Chang
H James Harwood
Marie T Vanier
Patrick C Reid
Ta Yuan Chang
William F Hickey
Yoshiko Ohno-Iwashita
P2860
P356
10.1016/J.JNEUMETH.2007.09.002
P577
2007-09-12T00:00:00Z