An ivermectin-sensitive glutamate-gated chloride channel from the parasitic nematode Haemonchus contortus.
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Glutamate-gated chloride channelsGenome-wide SNP analysis using 2b-RAD sequencing identifies the candidate genes putatively associated with resistance to ivermectin in Haemonchus contortusGlutamate-gated chloride channels of Haemonchus contortus restore drug sensitivity to ivermectin resistant Caenorhabditis elegansThe transcriptional response of Caenorhabditis elegans to Ivermectin exposure identifies novel genes involved in the response to reduced food intakeMolecular cloning and characterization of novel glutamate-gated chloride channel subunits from Schistosoma mansoniExpression of nicotinic acetylcholine receptor subunits from parasitic nematodes in Caenorhabditis elegans.An internally modulated, thermostable, pH-sensitive Cys loop receptor from the hydrothermal vent worm Alvinella pompejanaHow do the macrocyclic lactones kill filarial nematode larvae?An improved ivermectin-activated chloride channel receptor for inhibiting electrical activity in defined neuronal populationsHigh level expression of a glutamate-gated chloride channel gene in reproductive tissues of Brugia malayi may explain the sterilizing effect of ivermectin on filarial worms.Ocular onchocerciasis: current management and future prospectsComparative pharmacology of flatworm and roundworm glutamate-gated chloride channels: Implications for potential anthelmintics.Recent advances in candidate-gene and whole-genome approaches to the discovery of anthelmintic resistance markers and the description of drug/receptor interactions.Anthelmintic resistance: markers for resistance, or susceptibility?Salmon lice (Lepeophtheirus salmonis) showing varying emamectin benzoate susceptibilities differ in neuronal acetylcholine receptor and GABA-gated chloride channel mRNA expressionMolecular determinants of ivermectin sensitivity at the glycine receptor chloride channelCharacterization of the target of ivermectin, the glutamate-gated chloride channel, from Anopheles gambiae.Natural variation in a chloride channel subunit confers avermectin resistance in C. elegans.Molecular mechanisms of Cys-loop ion channel receptor modulation by ivermectin.Analysis of putative resistance gene loci in UK field populations of Haemonchus contortus after 6years of macrocyclic lactone use.Teladorsagia circumcincta: Molecular characterisation of the avr-14B subunit and its relatively minor role in ivermectin resistance.Derquantel and abamectin: effects and interactions on isolated tissues of Ascaris suum.Ion channels and receptor as targets for the control of parasitic nematodes.Current drug targets for helminthic diseases.Rhipicephalus (Boophilus) microplus resistant to acaricides and ivermectin in cattle farms of Mexico.Molecular mechanisms for anthelmintic resistance in strongyle nematode parasites of veterinary importance.Unique Contributions of an Arginine Side Chain to Ligand Recognition in a Glutamate-gated Chloride Channel.Molecular basis for convergent evolution of glutamate recognition by pentameric ligand-gated ion channels.GABA and glutamate receptors have different effects on excitability and are differentially regulated by calcium in spider mechanosensory neurons.Trapping of ivermectin by a pentameric ligand-gated ion channel upon open-to-closed isomerization.Mutational Analysis at Intersubunit Interfaces of an Anionic Glutamate Receptor Reveals a Key Interaction Important for Channel Gating by Ivermectin.Effects of glutamate and ivermectin on single glutamate-gated chloride channels of the parasitic nematode H. contortus.Increased Expression of a MicroRNA Correlates with Anthelmintic Resistance in Parasitic Nematodes.A G326E substitution in the glutamate-gated chloride channel 3 (GluCl3) of the two-spotted spider mite Tetranychus urticae abolishes the agonistic activity of macrocyclic lactones.Expression pattern and pharmacological characterisation of two novel alternative splice variants of the glutamate-gated chloride channel in the small brown planthopper Laodelphax striatellus.Ivermectin and its target molecules: shared and unique modulation mechanisms of ion channels and receptors by ivermectin.Ivermectin activates GIRK channels in a PIP2 -dependent, Gβγ -independent manner and an amino acid residue at the slide helix governs the activation.Glutamate-gated chloride channel subunit cDNA sequencing of Cochliomyia hominivorax (Diptera: Calliphoridae): cDNA variants and polymorphisms.Alcohol reduces muscle fatigue through atomistic interactions with nicotinic receptors
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An ivermectin-sensitive glutamate-gated chloride channel from the parasitic nematode Haemonchus contortus.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 31 March 2009
@en
vedecký článok
@sk
vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
An ivermectin-sensitive glutam ...... nematode Haemonchus contortus.
@en
An ivermectin-sensitive glutam ...... nematode Haemonchus contortus.
@nl
type
label
An ivermectin-sensitive glutam ...... nematode Haemonchus contortus.
@en
An ivermectin-sensitive glutam ...... nematode Haemonchus contortus.
@nl
prefLabel
An ivermectin-sensitive glutam ...... nematode Haemonchus contortus.
@en
An ivermectin-sensitive glutam ...... nematode Haemonchus contortus.
@nl
P2093
P2860
P356
P1476
An ivermectin-sensitive glutam ...... nematode Haemonchus contortus.
@en
P2093
Adrian J Wolstenholme
Adrian T Rogers
Darran M Yates
Debra J Woods
Samantha McCavera
P2860
P304
P356
10.1124/MOL.108.053363
P577
2009-03-31T00:00:00Z