Damage response of XRCC1 at sites of DNA single strand breaks is regulated by phosphorylation and ubiquitylation after degradation of poly(ADP-ribose).
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Base Excision Repair, a Pathway Regulated by Posttranslational ModificationsThe structural basis of XRCC1-mediated DNA repairMicrohomology-mediated end joining is activated in irradiated human cells due to phosphorylation-dependent formation of the XRCC1 repair complex.Tankyrase1-mediated poly(ADP-ribosyl)ation of TRF1 maintains cell survival after telomeric DNA damage.Development of synthetic lethality anticancer therapeutics.A quantitative assay reveals ligand specificity of the DNA scaffold repair protein XRCC1 and efficient disassembly of complexes of XRCC1 and the poly(ADP-ribose) polymerase 1 by poly(ADP-ribose) glycohydrolase.New paradigms in the repair of oxidative damage in human genome: mechanisms ensuring repair of mutagenic base lesions during replication and involvement of accessory proteins.Differential phosphorylation of DNA-PKcs regulates the interplay between end-processing and end-ligation during nonhomologous end-joining.Targeted DNA damage at individual telomeres disrupts their integrity and triggers cell death.Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells.p38 MAPK signaling and phosphorylations in the BRCT1 domain regulate XRCC1 recruitment to sites of DNA damageEpithelial cell senescence: an adaptive response to pre-carcinogenic stresses?Poly(ADP-ribose) polymerase 1 escorts XPC to UV-induced DNA lesions during nucleotide excision repair.The PARP inhibitor olaparib enhances the cytotoxicity of combined gemcitabine, busulfan and melphalan in lymphoma cells.Effect of AICAR and 5-Fluorouracil on X-ray Repair, Cross-Complementing Group 1 Expression, and Consequent Cytotoxicity Regulation in Human HCT-116 Colorectal Cancer Cells.RAD52 is required for RNA-templated recombination repair in post-mitotic neurons.SSRP1 Cooperates with PARP and XRCC1 to Facilitate Single-Strand DNA Break Repair by Chromatin Priming.
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P2860
Damage response of XRCC1 at sites of DNA single strand breaks is regulated by phosphorylation and ubiquitylation after degradation of poly(ADP-ribose).
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 18 July 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Damage response of XRCC1 at si ...... tion after degradation of poly
@nl
Damage response of XRCC1 at si ...... gradation of poly(ADP-ribose).
@en
type
label
Damage response of XRCC1 at si ...... tion after degradation of poly
@nl
Damage response of XRCC1 at si ...... gradation of poly(ADP-ribose).
@en
prefLabel
Damage response of XRCC1 at si ...... tion after degradation of poly
@nl
Damage response of XRCC1 at si ...... gradation of poly(ADP-ribose).
@en
P2093
P2860
P356
P1476
Damage response of XRCC1 at si ...... gradation of poly(ADP-ribose).
@en
P2093
Akira Yasui
Arthur S Levine
Ching-Lung Hsieh
Leizhen Wei
Mitsuko Masutani
Satoshi Nakajima
Shinichiro Kanno
P2860
P304
P356
10.1242/JCS.128272
P407
P577
2013-07-18T00:00:00Z