Targeted deletion of tumor suppressor PTEN augments neutrophil function and enhances host defense in neutropenia-associated pneumonia
about
Phosphoinositides: tiny lipids with giant impact on cell regulationLoss of mitochondrial protein Fus1 augments host resistance to Acinetobacter baumannii infectionPhosphoinositide lipid phosphatase SHIP1 and PTEN coordinate to regulate cell migration and adhesion.Regulation of PTEN activity by p38δ-PKD1 signaling in neutrophils confers inflammatory responses in the lung.Myeloid PTEN deficiency protects livers from ischemia reperfusion injury by facilitating M2 macrophage differentiation.Inhibition of protein tyrosine phosphatase non-receptor type 2 by PTP inhibitor XIX: Its role as a multiphosphatase inhibitor.Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse modelPTEN negatively regulates engulfment of apoptotic cells by modulating activation of Rac GTPase.PTEN limits alveolar macrophage function against Pseudomonas aeruginosa after bone marrow transplantation.Phosphatase PTEN is critically involved in post-myocardial infarction remodeling through the Akt/interleukin-10 signaling pathway.p53 Integrates host defense and cell fate during bacterial pneumoniaTumor suppressor p53 protects mice against Listeria monocytogenes infectionG-CSF maintains controlled neutrophil mobilization during acute inflammation by negatively regulating CXCR2 signaling.A network of interactions enables CCM3 and STK24 to coordinate UNC13D-driven vesicle exocytosis in neutrophils.Mincle activation enhances neutrophil migration and resistance to polymicrobial septic peritonitis.Defective pulmonary innate immune responses post-stem cell transplantation; review and results from one model system.Molecular control of PtdIns(3,4,5)P3 signaling in neutrophils.Mechanism of Diapedesis: Importance of the Transcellular Route.Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signaling.Reactive oxygen species as signaling molecules in neutrophil chemotaxis.Relevant mouse model for human monocytic leukemia through Cre/lox-controlled myeloid-specific deletion of PTEN.Role of negative regulation of immune signaling pathways in neutrophil function.Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death.PTEN at the interface of immune tolerance and tumor suppression.Regulation of Hematopoietic Cell Development and Function Through Phosphoinositides.
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P2860
Targeted deletion of tumor suppressor PTEN augments neutrophil function and enhances host defense in neutropenia-associated pneumonia
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 13 March 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Targeted deletion of tumor sup ...... utropenia-associated pneumonia
@en
Targeted deletion of tumor sup ...... tropenia-associated pneumonia.
@nl
type
label
Targeted deletion of tumor sup ...... utropenia-associated pneumonia
@en
Targeted deletion of tumor sup ...... tropenia-associated pneumonia.
@nl
prefLabel
Targeted deletion of tumor sup ...... utropenia-associated pneumonia
@en
Targeted deletion of tumor sup ...... tropenia-associated pneumonia.
@nl
P2093
P2860
P50
P1433
P1476
Targeted deletion of tumor sup ...... utropenia-associated pneumonia
@en
P2093
Anongnard Kasorn
Bara Sarraj
Bryanne E Robson
Dale T Umetsu
Hongbo R Luo
Keqiang Ye
Yonghui Jia
P2860
P304
P356
10.1182/BLOOD-2008-06-161414
P407
P577
2009-03-13T00:00:00Z