The use of structural biology in Janus kinase targeted drug discovery. - Wikidata - awgldk - TriplyDB

The use of structural biology in Janus kinase targeted drug discovery.

The use of structural biology in Janus kinase targeted drug discovery.

http://www.wikidata.org/entity/Q37206115

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Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor Structure-guided studies of the SHP-1/JAK1 interaction provide new insights into phosphatase catalytic domain substrate recognition Protection of porcine endothelial cells against apoptosis with interleukin-4.Inhibitors of JAK2 and JAK3: an update on the patent literature 2010 - 2012.STAT3 inhibitors: finding a home in lymphoma and leukemia.Selective JAK inhibitors.JAK Kinase Inhibitors as Possible Treatment for Myeloproliferative Disorders and Cancer: Patent Highlight Inhibition of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signalling pathway in rheumatoid synovial fibroblasts using small molecule compounds.Artocarpus altilis CG-901 alters critical nodes in the JH1-kinase domain of Janus kinase 2 affecting upstream JAK/STAT3 signaling.

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The use of structural biology in Janus kinase targeted drug discovery.

http://www.wikidata.org/entity/Q37206115

description

article científic

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article scientifique

@fr

articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on April 2011

@en

vedecký článok

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vetenskaplig artikel

@sv

videnskabelig artikel

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vědecký článek

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name

The use of structural biology in Janus kinase targeted drug discovery.

@en

The use of structural biology in Janus kinase targeted drug discovery.

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type

label

The use of structural biology in Janus kinase targeted drug discovery.

@en

The use of structural biology in Janus kinase targeted drug discovery.

@nl

prefLabel

The use of structural biology in Janus kinase targeted drug discovery.

@en

The use of structural biology in Janus kinase targeted drug discovery.

@nl

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Current Drug Targets

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The use of structural biology in Janus kinase targeted drug discovery.

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Nilda L Alicea-Velázquez

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Titus J Boggon

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The Janus kinases (Jaks)

Structural requirements of the interleukin-6 signal transducer gp130 for its interaction with Janus kinase 1: the receptor is crucial for kinase activation

Structural mechanism for STI-571 inhibition of abelson tyrosine kinase

The Pseudoactive Site of ILK Is Essential for Its Binding to α-Parvin and Localization to Focal Adhesions

Fragment-based discovery of JAK-2 inhibitors

Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity

Dissecting specificity in the Janus kinases: the structures of JAK-specific inhibitors complexed to the JAK1 and JAK2 protein tyrosine kinase domains

2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2

A novel chemotype of kinase inhibitors: Discovery of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors

Janus kinase 2 inhibitors. Synthesis and characterization of a novel polycyclic azaindole

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546-555

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scholarly article

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10.2174/138945011794751528

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4

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2011-04-01T00:00:00Z

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