Intraocular pressure elevation induces mitochondrial fission and triggers OPA1 release in glaucomatous optic nerve - Wikidata - awgldk - TriplyDB

Intraocular pressure elevation induces mitochondrial fission and triggers OPA1 release in glaucomatous optic nerve

Intraocular pressure elevation induces mitochondrial fission and triggers OPA1 release in glaucomatous optic nerve

http://www.wikidata.org/entity/Q37206487

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Mitochondrial pathogenic mechanism and degradation in optineurin E50K mutation-mediated retinal ganglion cell degeneration Glaucoma: the retina and beyond Presence and Risk Factors for Glaucoma in Patients with Diabetes.The micro-architecture of mitochondria at active zones: electron tomography reveals novel anchoring scaffolds and cristae structured for high-rate metabolism DRP1 inhibition rescues retinal ganglion cells and their axons by preserving mitochondrial integrity in a mouse model of glaucoma.Mitochondrial DNA analysis in primary congenital glaucoma Inducible nitric oxide synthase-mediated alteration of mitochondrial OPA1 expression in ocular hypertensive rats Increased optic atrophy type 1 expression protects retinal ganglion cells in a mouse model of glaucoma.Mitochondrial optic neuropathies - disease mechanisms and therapeutic strategies.Lipofuscin in human glaucomatous optic nerves.Raised intraocular pressure as a potential risk factor for visual loss in Leber Hereditary Optic Neuropathy A selective inhibitor of drp1, mdivi-1, increases retinal ganglion cell survival in acute ischemic mouse retina.Retinal ganglion cell dendritic atrophy in DBA/2J glaucoma Changes to mitochondrial ultrastructure in optic nerve vulnerable to secondary degeneration in vivo are limited by irradiation at 670 nm Deregulation of mitochondria-shaping proteins Opa-1 and Drp-1 in manganese-induced apoptosis Mitochondrial morphology differences and mitophagy deficit in murine glaucomatous optic nerve.The pathophysiology and treatment of glaucoma: a review.Increased mitochondrial fission and volume density by blocking glutamate excitotoxicity protect glaucomatous optic nerve head astrocytes.Adeno-associated virus mediated SOD gene therapy protects the retinal ganglion cells from chronic intraocular pressure elevation induced injury via attenuating oxidative stress and improving mitochondrial dysfunction in a rat model.Proteomics Analysis of Molecular Risk Factors in the Ocular Hypertensive Human Retina Using genetic mouse models to gain insight into glaucoma: Past results and future possibilities.Mitochondrial DNA nucleotide changes in primary congenital glaucoma patients Molecular imaging of retinal disease.Memantine blocks mitochondrial OPA1 and cytochrome c release and subsequent apoptotic cell death in glaucomatous retina.The mitochondrial permeability transition pore in motor neurons: involvement in the pathobiology of ALS mice.AUTOPHAGY, MITOCHONDRIAL DYNAMICS AND RETINAL DISEASES.Inhibition of oxidative stress by coenzyme Q10 increases mitochondrial mass and improves bioenergetic function in optic nerve head astrocytes.Coenzyme Q10 inhibits glutamate excitotoxicity and oxidative stress-mediated mitochondrial alteration in a mouse model of glaucoma.Mitochondrial Dynamics in Retinal Ganglion Cell Axon Regeneration and Growth Cone Guidance.Pathophysiology of human glaucomatous optic nerve damage: insights from rodent models of glaucoma.Molecular mechanisms of retinal ganglion cell degeneration in glaucoma and future prospects for cell body and axonal protection.Glaucoma and optic nerve repair.Dominant optic atrophy, OPA1, and mitochondrial quality control: understanding mitochondrial network dynamics.Management of glaucoma as a neurodegenerative disease.BAX to basics: How the BCL2 gene family controls the death of retinal ganglion cells.Axonal protection by Nmnat3 overexpression with involvement of autophagy in optic nerve degeneration.The potential impact of recent insights into proteomic changes associated with glaucoma.Metabolic Vulnerability in the Neurodegenerative Disease Glaucoma.Autophagy promotes survival of retinal ganglion cells after optic nerve axotomy in mice.Is Glaucoma a Neurodegeneration caused by Central Insulin Resistance: Diabetes Type 4?

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Intraocular pressure elevation induces mitochondrial fission and triggers OPA1 release in glaucomatous optic nerve

http://www.wikidata.org/entity/Q37206487

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scientific article published on 09 May 2008

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vedecký článok

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vetenskaplig artikel

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vědecký článek

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name

Intraocular pressure elevation ...... se in glaucomatous optic nerve

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Intraocular pressure elevation ...... e in glaucomatous optic nerve.

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Intraocular pressure elevation ...... se in glaucomatous optic nerve

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Intraocular pressure elevation ...... e in glaucomatous optic nerve.

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Intraocular pressure elevation ...... se in glaucomatous optic nerve

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Intraocular pressure elevation ...... e in glaucomatous optic nerve.

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Investigative Ophthalmology & Visual Science

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Intraocular pressure elevation ...... se in glaucomatous optic nerve

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Guy A Perkins

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Ismail Kukhmazov

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James D Lindsey

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James Jaeyoung Kim

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Karen X Duong-Polk

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Keun-Young Kim

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Mark H Ellisman

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Mila Angert

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Ray T Scott

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Won-Kyu Ju

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P2860

OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28

Primary structure of a dynamin-related mouse mitochondrial GTPase and its distribution in brain, subcellular localization, and effect on mitochondrial morphology

Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis

Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis

Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis

Computer visualization of three-dimensional image data using IMOD

Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy

Structure and dynamics of the mitochondrial inner membrane cristae

Mitochondrial dysfunction as a cause of optic neuropathies

OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion

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4903-4911

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scholarly article

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10.1167/IOVS.07-1661

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11

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49

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Robert N Weinreb

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2008-05-09T00:00:00Z

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5382731

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18469184

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