Gfi1 integrates progenitor versus granulocytic transcriptional programming.
about
A role of Miz-1 in Gfi-1-mediated transcriptional repression of CDKN1AContributions to neutropenia from PFAAP5 (N4BP2L2), a novel protein mediating transcriptional repressor cooperation between Gfi1 and neutrophil elastaseFrom cytopenia to leukemia: the role of Gfi1 and Gfi1b in blood formationTranscription factor-mediated reprogramming toward hematopoietic stem cellsGrowth factor independence 1 antagonizes a p53-induced DNA damage response pathway in lymphoblastic leukemia.Inactivation of Ezh2 Upregulates Gfi1 and Drives Aggressive Myc-Driven Group 3 Medulloblastoma.C/EBPepsilon directs granulocytic-vs-monocytic lineage determination and confers chemotactic function via Hlx.A variant allele of Growth Factor Independence 1 (GFI1) is associated with acute myeloid leukemia.Repression of Id2 expression by Gfi-1 is required for B-cell and myeloid developmentIdentification of E74-like factor 1 (ELF1) as a transcriptional regulator of the Hox cofactor MEIS1.Gfi-1 regulates the erythroid transcription factor network through Id2 repression in murine hematopoietic progenitor cells.Expression of the transcriptional repressor Gfi-1 is regulated by C/EBP{alpha} and is involved in its proliferation and colony formation-inhibitory effects in p210BCR/ABL-expressing cellsDifferential transcriptional regulation of meis1 by Gfi1b and its co-factors LSD1 and CoRESTGFI1 is repressed by p53 and inhibits DNA damage-induced apoptosis.Growth factor independent-1 maintains Notch1-dependent transcriptional programming of lymphoid precursors.Gfi1 and gfi1b repress rag transcription in plasmacytoid dendritic cells in vitroGABP transcription factor is required for myeloid differentiation, in part, through its control of Gfi-1 expressionMIR-23A microRNA cluster inhibits B-cell development.Gfi1 expressed in bone marrow stromal cells is a novel osteoblast suppressor in patients with multiple myeloma bone disease.Therapeutic antagonists of microRNAs deplete leukemia-initiating cell activity.Hoxa9 regulates Flt3 in lymphohematopoietic progenitors.Gfi1-cells and circuits: unraveling transcriptional networks of development and diseaseGfi1 and Gfi1b: key regulators of hematopoiesis.Gfi-1 inhibits proliferation and colony formation of p210BCR/ABL-expressing cells via transcriptional repression of STAT 5 and Mcl-1.MicroRNAs in Myeloid Hematological Malignancies.GFI1(36N) as a therapeutic and prognostic marker for myelodysplastic syndromeThe MYB proto-oncogene suppresses monocytic differentiation of acute myeloid leukemia cells via transcriptional activation of its target gene GFI1.GFI1 as a novel prognostic and therapeutic factor for AML/MDS.Prognostic significance of high GFI1 expression in AML of normal karyotype and its association with a FLT3-ITD signature.Low GFI1 expression in white blood cells of CP-CML patients at diagnosis is strongly associated with subsequent blastic transformation.Growth factor independence 1 protects hematopoietic stem cells against apoptosis but also prevents the development of a myeloproliferative-like disease.Enforced GFI1 expression impedes human and murine leukemic cell growth.GFI1 is required for RUNX1/ETO positive acute myeloid leukemia.MicroRNA in Myelopoiesis and Myeloid Disorders
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Gfi1 integrates progenitor versus granulocytic transcriptional programming.
description
article científic
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article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 03 April 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Gfi1 integrates progenitor versus granulocytic transcriptional programming.
@en
Gfi1 integrates progenitor versus granulocytic transcriptional programming.
@nl
type
label
Gfi1 integrates progenitor versus granulocytic transcriptional programming.
@en
Gfi1 integrates progenitor versus granulocytic transcriptional programming.
@nl
prefLabel
Gfi1 integrates progenitor versus granulocytic transcriptional programming.
@en
Gfi1 integrates progenitor versus granulocytic transcriptional programming.
@nl
P2093
P2860
P1433
P1476
Gfi1 integrates progenitor versus granulocytic transcriptional programming.
@en
P2093
Aditya Chaubey
Brian Gebelein
Chinavenmeni S Velu
H Leighton Grimes
Jinfang Zhu
Shane R Horman
Tristan Bourdeau
William E Paul
P2860
P304
P356
10.1182/BLOOD-2008-09-179747
P407
P577
2009-04-03T00:00:00Z