Capsid antigen presentation flags human hepatocytes for destruction after transduction by adeno-associated viral vectors. - Wikidata - awgldk - TriplyDB

Capsid antigen presentation flags human hepatocytes for destruction after transduction by adeno-associated viral vectors.

Capsid antigen presentation flags human hepatocytes for destruction after transduction by adeno-associated viral vectors.

http://www.wikidata.org/entity/Q37209197

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The gene therapy journey for hemophilia: are we there yet?State-of-the-art human gene therapy: part I. Gene delivery technologies Progress and prospects: immune responses to viral vectors A universal system to select gene-modified hepatocytes in vivo Evaluation of engineered AAV capsids for hepatic factor IX gene transfer in murine and canine models Adenoviral Vectors for Hemophilia Gene Therapy The pleiotropic effects of natural AAV infections on liver-directed gene transfer in macaques Influence of immune responses in gene/stem cell therapies for muscular dystrophies.Progress towards gene therapy for haemophilia B.Gene therapy for monogenic liver diseases: clinical successes, current challenges and future prospects.The potential of adeno-associated viral vectors for gene delivery to muscle tissue.Cell-Mediated Immunity to AAV Vectors, Evolving Concepts and Potential Solutions.Gene therapy with mitochondrial heat shock protein 70 suppresses visual loss and optic atrophy in experimental autoimmune encephalomyelitis.Adeno-associated virus (AAV) vectors in gene therapy: immune challenges and strategies to circumvent them.High-efficiency transduction and correction of murine hemophilia B using AAV2 vectors devoid of multiple surface-exposed tyrosines.Activation of the cellular unfolded protein response by recombinant adeno-associated virus vectors.LHON gene therapy vector prevents visual loss and optic neuropathy induced by G11778A mutant mitochondrial DNA: biodistribution and toxicology profile.Safety and effects of the vector for the Leber hereditary optic neuropathy gene therapy clinical trial.Systemic elimination of de novo capsid protein synthesis from replication-competent AAV contamination in the liver Large-scale recombinant adeno-associated virus production Perinatal gene transfer to the liver.Gene therapy for the nervous system: challenges and new strategies.AAV capsid CD8+ T-cell epitopes are highly conserved across AAV serotypes Immunosuppression decreases inflammation and increases AAV6-hSERCA2a-mediated SERCA2a expression The threefold protrusions of adeno-associated virus type 8 are involved in cell surface targeting as well as postattachment processing.Ac45 silencing mediated by AAV-sh-Ac45-RNAi prevents both bone loss and inflammation caused by periodontitis.Gene Therapy for Duchenne muscular dystrophy.An Immune-Competent Murine Model to Study Elimination of AAV-Transduced Hepatocytes by Capsid-Specific CD8+ T Cells Site-Directed Mutagenesis of Surface-Exposed Lysine Residues Leads to Improved Transduction by AAV2, But Not AAV8, Vectors in Murine Hepatocytes In Vivo Strategies to circumvent humoral immunity to adeno-associated viral vectors.Adeno-associated virus capsid antigen presentation is dependent on endosomal escape.Engineered AAV vector minimizes in vivo targeting of transduced hepatocytes by capsid-specific CD8+ T cells.Immune responses to AAV vectors: overcoming barriers to successful gene therapy A concept of eliminating nonhomologous recombination for scalable and safe AAV vector generation for human gene therapy Superior In vivo Transduction of Human Hepatocytes Using Engineered AAV3 Capsid.CFTR gene transfer with AAV improves early cystic fibrosis pig phenotypes Human Treg responses allow sustained recombinant adeno-associated virus-mediated transgene expression.Helper-Dependent Adenoviral Vectors.Promise and problems associated with the use of recombinant AAV for the delivery of anti-HIV antibodies AAV-mediated gene therapy for liver diseases: the prime candidate for clinical application?

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Capsid antigen presentation flags human hepatocytes for destruction after transduction by adeno-associated viral vectors.

http://www.wikidata.org/entity/Q37209197

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 11 May 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

@cs

name

Capsid antigen presentation fl ...... deno-associated viral vectors.

@en

Capsid antigen presentation fl ...... deno-associated viral vectors.

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type

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Capsid antigen presentation fl ...... deno-associated viral vectors.

@en

Capsid antigen presentation fl ...... deno-associated viral vectors.

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Capsid antigen presentation fl ...... deno-associated viral vectors.

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Capsid antigen presentation fl ...... deno-associated viral vectors.

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Journal of Clinical Investigation

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Capsid antigen presentation fl ...... deno-associated viral vectors.

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Ashley N Mentlik

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Daniel J Hui

http://www.w3.org/2001/XMLSchema#string

Etiena Basner-Tschakarjan

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Federico Mingozzi

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Gary C Pien

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Jonathan D Finn

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Katherine A High

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Nicole C Hasbrouck

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Samuel L Murphy

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Shangzhen Zhou

http://www.w3.org/2001/XMLSchema#string

P2860

Signaling signatures and functional properties of anti-human CD28 superagonistic antibodies

Phenotypic analysis of antigen-specific T lymphocytes

ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells

Phagosomes are competent organelles for antigen cross-presentation

Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response

Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412

Identification of mouse AAV capsid-specific CD8+ T cell epitopes.

Endosomal processing limits gene transfer to polarized airway epithelia by adeno-associated virus.

Loss of Siglec expression on T lymphocytes during human evolution.

Induction of immune tolerance to coagulation factor IX antigen by in vivo hepatic gene transfer.

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1688-1695

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scholarly article

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10.1172/JCI36891

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6

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119

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2009-05-11T00:00:00Z

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19436115

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2689109

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