E. coli NfsA: an alternative nitroreductase for prodrug activation gene therapy in combination with CB1954 - Wikidata - awgldk - TriplyDB

E. coli NfsA: an alternative nitroreductase for prodrug activation gene therapy in combination with CB1954

E. coli NfsA: an alternative nitroreductase for prodrug activation gene therapy in combination with CB1954

http://www.wikidata.org/entity/Q37212365

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The Flavin Reductase MsuE Is a Novel Nitroreductase that Can Efficiently Activate Two Promising Next-Generation Prodrugs for Gene-Directed Enzyme Prodrug Therapy Altering the regioselectivity of a nitroreductase in the synthesis of arylhydroxylamines by structure-based engineering Spores of Clostridium engineered for clinical efficacy and safety cause regression and cure of tumors in vivo Selective esterase-ester pair for targeting small molecules with cellular specificity.Application of 6-nitrocoumarin as a substrate for the fluorescent detection of nitroreductase activity in Sporothrix schenckii Flavin-containing reductase: new perspective on the detoxification of nitrobenzodiazepine.Enzyme/Prodrug Systems for Cancer Gene Therapy.Targeting and delivery of therapeutic enzymes.Minimal RB-responsive E1A promoter modification to attain potency, selectivity, and transgene-arming capacity in oncolytic adenoviruses.Residue Phe42 is critical for the catalytic activity of Escherichia coli major nitroreductase NfsA.Expanding the Genetic Code for a Dinitrophenyl Hapten.Evaluation of NfsA-like nitroreductases from Neisseria meningitidis and Bartonella henselae for enzyme-prodrug therapy, targeted cellular ablation, and dinitrotoluene bioremediation.Heterologous Overexpression and Biochemical Characterization of a Nitroreductase from Gluconobacter oxydans 621H.

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E. coli NfsA: an alternative nitroreductase for prodrug activation gene therapy in combination with CB1954

http://www.wikidata.org/entity/Q37212365

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 19 May 2009

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

@cs

name

E. coli NfsA: an alternative n ...... apy in combination with CB1954

@en

E. coli NfsA: an alternative n ...... py in combination with CB1954.

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type

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E. coli NfsA: an alternative n ...... apy in combination with CB1954

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E. coli NfsA: an alternative n ...... py in combination with CB1954.

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prefLabel

E. coli NfsA: an alternative n ...... apy in combination with CB1954

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E. coli NfsA: an alternative n ...... py in combination with CB1954.

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British Journal of Cancer

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E. coli NfsA: an alternative n ...... apy in combination with CB1954

@en

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D Jarrom

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E I Hyde

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P F Searle

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S O Vass

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W R Wilson

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P2860

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

Structure and site-directed mutagenesis of a flavoprotein from Escherichia coli that reduces nitrocompounds: alteration of pyridine nucleotide binding by a single amino acid substitution

The structure of Escherichia coli nitroreductase complexed with nicotinic acid: three crystal forms at 1.7 A, 1.8 A and 2.4 A resolution

NAD kinase levels control the NADPH concentration in human cells

New colorimetric cytotoxicity assay for anticancer-drug screening

Combined adenovirus-mediated nitroreductase gene delivery and CB1954 treatment: a well-tolerated therapy for established solid tumors.

Generation of Escherichia coli nitroreductase mutants conferring improved cell sensitization to the prodrug CB1954.

Virus-directed enzyme prodrug therapy using CB1954.

Biochemical characterization of NfsA, the Escherichia coli major nitroreductase exhibiting a high amino acid sequence homology to Frp, a Vibrio harveyi flavin oxidoreductase.

High-titer packaging cells producing recombinant retroviruses resistant to human serum

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1903-1911

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scholarly article

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10.1038/SJ.BJC.6605094

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12

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100

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2009-05-19T00:00:00Z

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24439739

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19455141

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Escherichia coli

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2690450

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