E. coli NfsA: an alternative nitroreductase for prodrug activation gene therapy in combination with CB1954
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The Flavin Reductase MsuE Is a Novel Nitroreductase that Can Efficiently Activate Two Promising Next-Generation Prodrugs for Gene-Directed Enzyme Prodrug TherapyAltering the regioselectivity of a nitroreductase in the synthesis of arylhydroxylamines by structure-based engineeringSpores of Clostridium engineered for clinical efficacy and safety cause regression and cure of tumors in vivoSelective esterase-ester pair for targeting small molecules with cellular specificity.Application of 6-nitrocoumarin as a substrate for the fluorescent detection of nitroreductase activity in Sporothrix schenckiiFlavin-containing reductase: new perspective on the detoxification of nitrobenzodiazepine.Enzyme/Prodrug Systems for Cancer Gene Therapy.Targeting and delivery of therapeutic enzymes.Minimal RB-responsive E1A promoter modification to attain potency, selectivity, and transgene-arming capacity in oncolytic adenoviruses.Residue Phe42 is critical for the catalytic activity of Escherichia coli major nitroreductase NfsA.Expanding the Genetic Code for a Dinitrophenyl Hapten.Evaluation of NfsA-like nitroreductases from Neisseria meningitidis and Bartonella henselae for enzyme-prodrug therapy, targeted cellular ablation, and dinitrotoluene bioremediation.Heterologous Overexpression and Biochemical Characterization of a Nitroreductase from Gluconobacter oxydans 621H.
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E. coli NfsA: an alternative nitroreductase for prodrug activation gene therapy in combination with CB1954
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 19 May 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
E. coli NfsA: an alternative n ...... apy in combination with CB1954
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E. coli NfsA: an alternative n ...... py in combination with CB1954.
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type
label
E. coli NfsA: an alternative n ...... apy in combination with CB1954
@en
E. coli NfsA: an alternative n ...... py in combination with CB1954.
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prefLabel
E. coli NfsA: an alternative n ...... apy in combination with CB1954
@en
E. coli NfsA: an alternative n ...... py in combination with CB1954.
@nl
P2093
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E. coli NfsA: an alternative n ...... apy in combination with CB1954
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P2860
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10.1038/SJ.BJC.6605094
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2009-05-19T00:00:00Z