Interleukin-4 induces senescence in human renal carcinoma cell lines through STAT6 and p38 MAPK.
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Deriving a cardiac ageing signature to reveal MMP-9-dependent inflammatory signalling in senescence.Early infiltration of p40IL12(+)CCR7(+)CD11b(+) cells is critical for fibrosis development.Tumor growth suppressive effect of IL-4 through p21-mediated activation of STAT6 in IL-4Rα overexpressed melanoma models.Cellular senescence, senescence-associated secretory phenotype, and chronic kidney diseaseFunctional PTGS2 polymorphism-based models as novel predictive markers in metastatic renal cell carcinoma patients receiving first-line sunitinib.Critical role of p38 MAPK in IL-4-induced alternative activation of peritoneal macrophages.TNFα-senescence initiates a STAT-dependent positive feedback loop, leading to a sustained interferon signature, DNA damage, and cytokine secretion.
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Interleukin-4 induces senescence in human renal carcinoma cell lines through STAT6 and p38 MAPK.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 09 August 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Interleukin-4 induces senescen ...... es through STAT6 and p38 MAPK.
@en
Interleukin-4 induces senescen ...... es through STAT6 and p38 MAPK.
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type
label
Interleukin-4 induces senescen ...... es through STAT6 and p38 MAPK.
@en
Interleukin-4 induces senescen ...... es through STAT6 and p38 MAPK.
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prefLabel
Interleukin-4 induces senescen ...... es through STAT6 and p38 MAPK.
@en
Interleukin-4 induces senescen ...... es through STAT6 and p38 MAPK.
@nl
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Interleukin-4 induces senescen ...... es through STAT6 and p38 MAPK.
@en
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Hag Dong Kim
Hee Suk Kim
Jeong Min Choe
Jeongwon Sohn
Yong-Jin Kim
Yun Gyu Park
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P304
28743-28754
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10.1074/JBC.M113.499053
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P577
2013-08-09T00:00:00Z