Histone deacetylase inhibition promotes osteoblast maturation by altering the histone H4 epigenome and reduces Akt phosphorylation.
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The RUNX2 cistrome in osteoblasts: characterization, down-regulation following differentiation, and relationship to gene expression.miR-365 Ameliorates Dexamethasone-Induced Suppression of Osteogenesis in MC3T3-E1 Cells by Targeting HDAC4.PI3K/mTOR inhibition markedly potentiates HDAC inhibitor activity in NHL cells through BIM- and MCL-1-dependent mechanisms in vitro and in vivo.Histone deacetylase inhibition destabilizes the multi-potent state of uncommitted adipose-derived mesenchymal stromal cellsEpigenetic Control of Skeletal Development by the Histone Methyltransferase Ezh2Vorinostat synergizes with ridaforolimus and abrogates the ridaforolimus-induced activation of AKT in synovial sarcoma cells.A Novel Osteogenic Activity of Suberoylanilide Hydroxamic Acid is Synergized by BMP-2.Epigenetic Library Screen Identifies Abexinostat as Novel Regulator of Adipocytic and Osteoblastic Differentiation of Human Skeletal (Mesenchymal) Stem CellsEpigenetic histone modifications and master regulators as determinants of context dependent nuclear receptor activity in bone cellsHistone Deacetylases in Bone Development and Skeletal Disorders.Histone Deacetylase Inhibitors Target the Leukemic Microenvironment by Enhancing a Nherf1-Protein Phosphatase 1α-TAZ Signaling Pathway in OsteoblastsGlucocorticoid receptor and Histone deacetylase 6 mediate the differential effect of dexamethasone during osteogenesis of mesenchymal stromal cells (MSCs).Bone cell senescence: mechanisms and perspectives.Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders.Chromatin modifiers and histone modifications in bone formation, regeneration, and therapeutic intervention for bone-related disease.Enhancer of Zeste Homolog 2 Inhibition Stimulates Bone Formation and Mitigates Bone Loss Caused by Ovariectomy in Skeletally Mature Mice.Butyrate reduces high-fat diet-induced metabolic alterations, hepatic steatosis and pancreatic beta cell and intestinal barrier dysfunctions in prediabetic mice.Epigenetic regulation of bone cells.Profiling of human epigenetic regulators using a semi-automated real-time qPCR platform validated by next generation sequencing.Role of the PDZ-scaffold protein NHERF1/EBP50 in cancer biology: from signaling regulation to clinical relevance.Loss of Hdac3 in osteoprogenitors increases bone expression of osteoprotegerin, improving systemic insulin sensitivity.Histone Deacetylase Inhibitor Trichostatin a Promotes the Apoptosis of Osteosarcoma Cells through p53 Signaling Pathway Activation.Histone H4 Methyltransferase Suv420h2 Maintains Fidelity of Osteoblast Differentiation.The Histone-Deacetylase-Inhibitor Suberoylanilide Hydroxamic Acid Promotes Dental Pulp Repair Mechanisms Through Modulation of Matrix Metalloproteinase-13 Activity.Genome-wide DNase hypersensitivity, and occupancy of RUNX2 and CTCF reveal a highly dynamic gene regulome during MC3T3 pre-osteoblast differentiation.Histone deacetylase inhibitors reduce differentiating osteoblast-mediated protection of acute myeloid leukemia cells from cytarabine.Low-level overexpression of p53 promotes warfarin-induced calcification of porcine aortic valve interstitial cells by activating Slug gene transcription.Systemic tracking of diagnostic function modules for post-menopausal osteoporosis in a differential co-expression network view.
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Histone deacetylase inhibition promotes osteoblast maturation by altering the histone H4 epigenome and reduces Akt phosphorylation.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 12 August 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Histone deacetylase inhibition ...... d reduces Akt phosphorylation.
@en
Histone deacetylase inhibition ...... d reduces Akt phosphorylation.
@nl
type
label
Histone deacetylase inhibition ...... d reduces Akt phosphorylation.
@en
Histone deacetylase inhibition ...... d reduces Akt phosphorylation.
@nl
prefLabel
Histone deacetylase inhibition ...... d reduces Akt phosphorylation.
@en
Histone deacetylase inhibition ...... d reduces Akt phosphorylation.
@nl
P2093
P2860
P356
P1476
Histone deacetylase inhibition ...... nd reduces Akt phosphorylation
@en
P2093
Amel Dudakovic
Andre J van Wijnen
Jared M Evans
Jennifer J Westendorf
P2860
P304
28783-28791
P356
10.1074/JBC.M113.489732
P407
P577
2013-08-12T00:00:00Z