Increased insulin sensitivity in mice lacking collectrin, a downstream target of HNF-1alpha. - Wikidata - awgldk - TriplyDB

Increased insulin sensitivity in mice lacking collectrin, a downstream target of HNF-1alpha.

Increased insulin sensitivity in mice lacking collectrin, a downstream target of HNF-1alpha.

http://www.wikidata.org/entity/Q37214981

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Renal Collectrin Protects against Salt-Sensitive Hypertension and Is Downregulated by Angiotensin II.Identification of novel inhibitors of the amino acid transporter B0 AT1 (SLC6A19), a potential target to induce protein restriction and to treat type 2 diabetes.Identification of known and novel pancreas genes expressed downstream of Nkx2.2 during development Classical Renin-Angiotensin system in kidney physiology Adipose tissue promotes a serum cytokine profile related to lower insulin sensitivity after chronic central leptin infusion Angiotensin-converting enzyme 2: the first decade.Mice lacking neutral amino acid transporter B(0)AT1 (Slc6a19) have elevated levels of FGF21 and GLP-1 and improved glycaemic control.ACE2 deficiency reduces β-cell mass and impairs β-cell proliferation in obese C57BL/6 mice Pancreatic islet and progenitor cell surface markers with cell sorting potential.

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Increased insulin sensitivity in mice lacking collectrin, a downstream target of HNF-1alpha.

http://www.wikidata.org/entity/Q37214981

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 26 February 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Increased insulin sensitivity ...... wnstream target of HNF-1alpha.

@en

Increased insulin sensitivity ...... wnstream target of HNF-1alpha.

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type

label

Increased insulin sensitivity ...... wnstream target of HNF-1alpha.

@en

Increased insulin sensitivity ...... wnstream target of HNF-1alpha.

@nl

prefLabel

Increased insulin sensitivity ...... wnstream target of HNF-1alpha.

@en

Increased insulin sensitivity ...... wnstream target of HNF-1alpha.

@nl

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Molecular Endocrinology

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Increased insulin sensitivity ...... wnstream target of HNF-1alpha.

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Christopher B Newgard

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Danhong Lu

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Hans E Hohmeier

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Robert D Stevens

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Sandra M Malakauskas

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Thu H Le

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Timothy R Koves

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Wissam M Kourany

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Xiao Yin Zhang

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The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation

Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man

Laron dwarfism and non-insulin-dependent diabetes mellitus in the Hnf-1alpha knockout mouse.

Hepatocyte nuclear factor 1 inactivation results in hepatic dysfunction, phenylketonuria, and renal Fanconi syndrome

Collectrin, a collecting duct-specific transmembrane glycoprotein, is a novel homolog of ACE2 and is developmentally regulated in embryonic kidneys

Essential role for collectrin in renal amino acid transport

Defective pancreatic beta-cell glycolytic signaling in hepatocyte nuclear factor-1alpha-deficient mice

Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice

Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle

Hepatic nuclear factor 1 (HNF1) shows a wider distribution than products of its known target genes in developing mouse

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881-892

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scholarly article

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10.1210/ME.2008-0274

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6

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23

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Deborah M Muoio

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2009-02-26T00:00:00Z

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24043767

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19246514

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