Aberrant nuclear accumulation of glycogen synthase kinase-3beta in human pancreatic cancer: association with kinase activity and tumor dedifferentiation
about
ZM336372 induces apoptosis associated with phosphorylation of GSK-3beta in pancreatic adenocarcinoma cell linesPathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathwayGSK3A is redundant with GSK3B in modulating drug resistance and chemotherapy-induced necroptosisA computational strategy to select optimized protein targets for drug development toward the control of cancer diseasesGlycogen synthase kinase-3 inhibition sensitizes pancreatic cancer cells to TRAIL-induced apoptosisPrimers on molecular pathways. The glycogen synthase kinase-3betaGlycogen synthase kinase-3 inhibition disrupts nuclear factor-kappaB activity in pancreatic cancer, but fails to sensitize to gemcitabine chemotherapyA novel role for GSK3β as a modulator of Drosha microprocessor activity and MicroRNA biogenesisGlycogen Synthase Kinase-3 regulates multiple myeloma cell growth and bortezomib-induced cell deathP27(Kip1), regulated by glycogen synthase kinase-3β, results in HMBA-induced differentiation of human gastric cancer cells.Combination Treatment with the GSK-3 Inhibitor 9-ING-41 and CCNU Cures Orthotopic Chemoresistant Glioblastoma in Patient-Derived Xenograft Models.Lithium inhibits carcinoid cell growth in vitroGlycogen synthase kinase-3β is associated with the prognosis of hepatocellular carcinoma and may mediate the influence of type 2 diabetes mellitus on hepatocellular carcinoma.Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention.Glycogen synthase kinase 3 protein kinase activity is frequently elevated in human non-small cell lung carcinoma and supports tumour cell proliferation.Citrus flavonoids luteolin, apigenin, and quercetin inhibit glycogen synthase kinase-3β enzymatic activity by lowering the interaction energy within the binding cavity.Insights into the interactions between maleimide derivates and GSK3β combining molecular docking and QSARThe marine natural product microsclerodermin A is a novel inhibitor of the nuclear factor kappa B and induces apoptosis in pancreatic cancer cells.Water extract of brewers' rice induces apoptosis in human colorectal cancer cells via activation of caspase-3 and caspase-8 and downregulates the Wnt/β-catenin downstream signaling pathway in brewers' rice-treated rats with azoxymethane-induced coloInhibition of glycogen synthase kinase-3 activity leads to epigenetic silencing of nuclear factor kappaB target genes and induction of apoptosis in chronic lymphocytic leukemia B cellsGlycogen synthase kinase-3 inhibitor AR-A014418 suppresses pancreatic cancer cell growth via inhibition of GSK-3-mediated Notch1 expression.GSK-3 promotes cell survival, growth, and PAX3 levels in human melanoma cellsThe role of glycogen synthase kinase-3 signaling in neurodevelopment and fragile X syndromeGlycogen Synthase Kinase 3 Beta Predicts Survival in Resected Adenocarcinoma of the PancreasAberrant glycogen synthase kinase 3β in the development of pancreatic cancer.GSK-3β regulates tumor growth and angiogenesis in human glioma cellsGlycogen synthase kinase-3: a potential preventive target for prostate cancer managementGlycogen synthase kinase 3beta (GSK3beta) in tumorigenesis and cancer chemotherapy.Nuclear GSK3β promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitylation by USP22.Glycogen synthase kinase 3β and cyclin D1 expression in cervical carcinogenesis.Glycogen synthase kinase-3: a new therapeutic target in renal cell carcinoma.Modulation of glycogen synthase kinase-3β following TRAIL combinatorial treatment in cancer cells.Inhibition of GSK-3β activity can result in drug and hormonal resistance and alter sensitivity to targeted therapy in MCF-7 breast cancer cells.Targeting Src-mediated Tyr216 phosphorylation and activation of GSK-3 in prostate cancer cells inhibit prostate cancer progression in vitro and in vivo.Aspirin inhibits proliferation of gemcitabine-resistant human pancreatic cancer cells and augments gemcitabine-induced cytotoxicityGlycogen synthase kinase 3 beta: can it be a target for oral cancer.Targeting phosphatidylinositol 3 kinase (PI3K)-Akt beyond rapalogs.The role of glycogen synthase kinase 3-β in immunity and cell cycle: implications in esophageal cancer.Glycogen Synthase Kinase 3β in Pancreatic Cancer and its Implications in Chemotherapy and Radiation Therapy.Mutant K-Ras increases GSK-3β gene expression via an ETS-p300 transcriptional complex in pancreatic cancer.
P2860
Q24600930-3FEDFA91-3921-4015-BF09-DBB03A2B9AC0Q24655318-E1EA5090-5168-43C9-90D5-F35BF47C9D06Q28540209-33516244-4E6C-41BE-A777-88E48768B6D5Q28543105-6BAA318B-1551-4E5F-A305-307885B4091AQ28729017-A2DFB313-363B-4CF1-80EF-4B7D408E4FEDQ33301293-510DB75D-5D0D-4E48-B274-8899E4A9E22BQ33437264-234A217E-00AB-4F88-AD90-18A94A5A9C27Q33557664-841955E8-7C99-4D6B-B9A9-DC5F673E859EQ33710200-603B9451-A647-4B3C-BFDB-73C9DBAC186CQ33856507-3C4A702E-FD6D-4F74-9E02-B1A2AE259194Q33869702-57388C2E-60A2-4409-8B15-067E2C85533DQ33942103-66009307-8E67-4695-A9F8-F521B50764F4Q34089689-CC10F60F-BF2D-4B38-81A0-A2A3A55140F3Q34103963-AF0B0468-F486-4358-A874-8A2D6388445AQ34654039-FB04903C-6CF0-4187-B819-861D60B193DBQ35070396-2F50242D-0171-4010-9B0F-C2FDE3BA5AFAQ35204391-99261D97-1C0B-4EDE-AA6C-975C8324E3EDQ35443211-501678EC-14AD-4577-B5B8-52D355019CA4Q35677634-B0321F2F-642C-46D7-8BD3-2F8140702D5DQ35900933-7C2FE9CC-D2AA-44DF-970F-5F62BCBE56B5Q36019650-5EC6B786-3B13-4437-9C4F-830D711D738AQ36173889-5050F83B-8191-41FF-99D9-3EEFEC6F0854Q36304058-21FD3F71-A113-414B-B779-78AF002AAD02Q36378003-22F2F2A6-2998-45E4-8DD8-A66D826FDAC2Q36450022-1443608C-1340-44CA-8C96-16802723D31BQ36544729-DB678CB2-8417-4462-9184-242ECA03FADFQ36580561-649A3299-1450-4F9A-A71F-91B61E7E2BF4Q37163149-DE5EF4EA-140F-470F-802C-4CE7C2EEF8B1Q37262177-0C756B94-6484-4932-A317-0AF9F1179295Q37430271-F1B89F42-CF5A-4194-AE1D-E60A7A6A9F59Q37481890-12F2639E-11A6-431A-A423-AF340E2CC24BQ37687091-9C36872B-C627-44B8-8CE7-52B131FD1381Q37692593-7769197C-6B42-4F49-9CA6-F4F5DB9A2E00Q37718461-05E1EF0C-9F5D-41FB-9645-1A89855A9CD9Q37728667-4F2CA9C4-DA05-4485-A700-B20F83165560Q37764097-10B076B2-71B4-471A-B850-53AB6414146FQ37872655-CAC749AA-0BBE-4737-87B9-F5F1C8FA6C32Q38166249-CA1AA481-2AE6-4118-B6D0-1D31964E5BF6Q38221504-8C673D55-D9E7-4901-AD4A-6133982CDD1FQ38262388-1955335C-0314-4358-9D0D-75D701F6096D
P2860
Aberrant nuclear accumulation of glycogen synthase kinase-3beta in human pancreatic cancer: association with kinase activity and tumor dedifferentiation
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on September 2006
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Aberrant nuclear accumulation ...... ty and tumor dedifferentiation
@en
Aberrant nuclear accumulation ...... y and tumor dedifferentiation.
@nl
type
label
Aberrant nuclear accumulation ...... ty and tumor dedifferentiation
@en
Aberrant nuclear accumulation ...... y and tumor dedifferentiation.
@nl
prefLabel
Aberrant nuclear accumulation ...... ty and tumor dedifferentiation
@en
Aberrant nuclear accumulation ...... y and tumor dedifferentiation.
@nl
P2093
P2860
P1476
Aberrant nuclear accumulation ...... ty and tumor dedifferentiation
@en
P2093
Andrei V Ougolkov
Daniel D Billadeau
Martin E Fernandez-Zapico
Suresh T Chari
Vladimir N Bilim
P2860
P304
P356
10.1158/1078-0432.CCR-06-0196
P407
P577
2006-09-01T00:00:00Z