Conformational selection is a dominant mechanism of ligand binding
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Conformational selection in protein binding and functionEssential role of conformational selection in ligand bindingStructural Studies of Yeast Δ 1 -Pyrroline-5-carboxylate Dehydrogenase (ALDH4A1): Active Site Flexibility and Oligomeric StateMolecular Basis of the General Base Catalysis of an / -Hydrolase Catalytic TriadAn allosteric switch for pro-HGF/Met signaling using zymogen activator peptidesLoop Electrostatics Asymmetry Modulates the Preexisting Conformational Equilibrium in ThrombinStructural basis for the Zn2+ inhibition of the zymogen-like kallikrein-related peptidase 10Effects of Glycosylation on the Enzymatic Activity and Mechanisms of ProteasesBinding Mechanisms of Intrinsically Disordered Proteins: Theory, Simulation, and ExperimentDynamics Govern Specificity of a Protein-Protein Interface: Substrate Recognition by ThrombinHow to Distinguish Conformational Selection and Induced Fit Based on Chemical Relaxation RatesmutLBSgeneDB: mutated ligand binding site gene DataBase.Monte Carlo replica-exchange based ensemble docking of protein conformations.Determinants of Macromolecular Specificity from Proteomics-Derived Peptide Substrate Data.An Asymmetric Conformational Change in LacY.Both protein dynamics and ligand concentration can shift the binding mechanism between conformational selection and induced fitThe role of conformational selection in the molecular recognition of the wild type and mutants XPA67-80 peptides by ERCC1.Structural Basis of Substrate Recognition by Aldehyde Dehydrogenase 7A1.Kinetic dissection of the pre-existing conformational equilibrium in the trypsin fold.What Mutagenesis Can and Cannot Reveal About Allostery.Histone H4 promotes prothrombin autoactivation.Transported substrate determines exchange rate in the multidrug resistance transporter EmrE.Ligand-detected relaxation dispersion NMR spectroscopy: dynamics of preQ1-RNA binding.Flexible receptor docking for drug discovery.Human melanoma inhibitory protein binds to the FN12-14 Hep II domain of fibronectin.Guided folding takes a start from the molecular imprinting of structured epitopes.High performance enzyme kinetics of turnover, activation and inhibition for translational drug discovery.An integrated perspective on RNA aptamer ligand-recognition models: clearing muddy waters.Rate Constants and Mechanisms of Protein-Ligand Binding.The red edge excitation shift phenomenon can be used to unmask protein structural ensembles: implications for NEMO-ubiquitin interactions.Biophysical evaluation of protein structural flexibility for ligand biorecognition in solid solution.Antibody humanization by molecular dynamics simulations-in-silico guided selection of critical backmutations.Substrate interaction dynamics and oxygen control in the active site of thymidylate synthase ThyX.Cis→Trans Isomerization of Pro(7) in Oxytocin Regulates Zn(2+) BindingA Kinetic Signature for Parallel Pathways: Conformational Selection and Induced Fit. Links and Disconnects between Observed Relaxation Rates and Fractional Equilibrium Flux under Pseudo-First-Order Conditions.Induced Fit Is a Special Case of Conformational Selection.The heme-regulatory motif of nuclear receptor Rev-erbβ is a key mediator of heme and redox signaling in circadian rhythm maintenance and metabolism.Improving protein-ligand docking with flexible interfacial water molecules using SWRosettaLigand.Interplay between conformational selection and zymogen activation.Human-like smelling of a rose scent using an olfactory receptor nanodisc-based bioelectronic nose
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Conformational selection is a dominant mechanism of ligand binding
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 15 August 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Conformational selection is a dominant mechanism of ligand binding
@en
Conformational selection is a dominant mechanism of ligand binding.
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type
label
Conformational selection is a dominant mechanism of ligand binding
@en
Conformational selection is a dominant mechanism of ligand binding.
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prefLabel
Conformational selection is a dominant mechanism of ligand binding
@en
Conformational selection is a dominant mechanism of ligand binding.
@nl
P2860
P356
P1433
P1476
Conformational selection is a dominant mechanism of ligand binding
@en
P2093
Austin D Vogt
Enrico Di Cera
P2860
P304
P356
10.1021/BI400929B
P407
P577
2013-08-15T00:00:00Z