Effect of the methoxychlor metabolite HPTE on the rat ovarian granulosa cell transcriptome in vitro.
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EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting ChemicalsEpigenetic effects of endocrine-disrupting chemicals on female reproduction: an ovarian perspectiveMono-hydroxy methoxychlor alters levels of key sex steroids and steroidogenic enzymes in cultured mouse antral follicles.Low concentrations of o,p'-DDT inhibit gene expression and prostaglandin synthesis by estrogen receptor-independent mechanism in rat ovarian cells.Methoxychlor and its metabolite HPTE inhibit cAMP production and expression of estrogen receptors α and β in the rat granulosa cell in vitro.Pregnenolone co-treatment partially restores steroidogenesis, but does not prevent growth inhibition and increased atresia in mouse ovarian antral follicles treated with mono-hydroxy methoxychlor.Molecular mechanism(s) of endocrine-disrupting chemicals and their potent oestrogenicity in diverse cells and tissues that express oestrogen receptorsMethoxychlor inhibits growth of antral follicles by altering cell cycle regulators.Effects of methoxychlor and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane on 3β-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase-3 activities in human and rat testes.Quantification of steroids and endocrine disrupting chemicals in rat ovaries by LC-MS/MS for reproductive toxicology assessment.Multi-residue analysis of free and conjugated hormones and endocrine disruptors in rat testis by QuEChERS-based extraction and LC-MS/MS.A Novel Action of Endocrine-Disrupting Chemicals on Wildlife; DDT and Its Derivatives Have Remained in the Environment.
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Effect of the methoxychlor metabolite HPTE on the rat ovarian granulosa cell transcriptome in vitro.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 04 May 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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Effect of the methoxychlor met ...... a cell transcriptome in vitro.
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Effect of the methoxychlor met ...... a cell transcriptome in vitro.
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Effect of the methoxychlor met ...... a cell transcriptome in vitro.
@en
Effect of the methoxychlor met ...... a cell transcriptome in vitro.
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Effect of the methoxychlor met ...... a cell transcriptome in vitro.
@en
Effect of the methoxychlor met ...... a cell transcriptome in vitro.
@nl
P2093
P2860
P356
P1476
Effect of the methoxychlor met ...... sa cell transcriptome in vitro
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Andrew I Brooks
Mahmoud Esmail
Mehmet Uzumcu
Rob Zachow
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P304
P356
10.1093/TOXSCI/KFP089
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2009-05-04T00:00:00Z