Towards the design of antiviral inhibitors against flaviviruses: the case for the multifunctional NS3 protein from Dengue virus as a target.
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Molecular targets for flavivirus drug discoveryDengue fever: diagnosis and treatmentThe role of viral persistence in flavivirus biologyStructure and functionality in flavivirus NS-proteins: perspectives for drug designNMR Analysis of the Dynamic Exchange of the NS2B Cofactor between Open and Closed Conformations of the West Nile Virus NS2B-NS3 ProteaseCrystal Structure of a Novel Conformational State of the Flavivirus NS3 Protein: Implications for Polyprotein Processing and Viral ReplicationSerotype-Specific Structural Differences in the Protease-Cofactor Complexes of the Dengue Virus FamilyFlexibility between the protease and helicase domains of the dengue virus NS3 protein conferred by the linker region and its functional implicationsLigand-Bound Structures of the Dengue Virus Protease Reveal the Active ConformationThe T4 Phage SF1B Helicase Dda Is Structurally Optimized to Perform DNA Strand SeparationFlavivirus NS3 and NS5 proteins interaction network: a high-throughput yeast two-hybrid screenScreening of Dengue virus antiviral activity of marine seaweeds by an in situ enzyme-linked immunosorbent assayInhibitors compounds of the flavivirus replication processBroad-spectrum agents for flaviviral infections: dengue, Zika and beyondA conformational switch high-throughput screening assay and allosteric inhibition of the flavivirus NS2B-NS3 protease.Transplantation of a hydrogen bonding network from West Nile virus protease onto Dengue-2 protease improves catalytic efficiency and sheds light on substrate specificity.Flaviviruses, an expanding threat in public health: focus on dengue, West Nile, and Japanese encephalitis virus.Insights into the internalization and retrograde trafficking of Dengue 2 virus in BHK-21 cells.New binding site conformations of the dengue virus NS3 protease accessed by molecular dynamics simulation.Isolation and characterization of selective and potent human Fab inhibitors directed to the active-site region of the two-component NS2B-NS3 proteinase of West Nile virus.Current Status of Dengue Therapeutics Research and Development.Virtual ligand screening of the National Cancer Institute (NCI) compound library leads to the allosteric inhibitory scaffolds of the West Nile Virus NS3 proteinase.Dengue.Inhibition of Dengue virus and West Nile virus proteases by click chemistry-derived benz[d]isothiazol-3(2H)-one derivatives.C-terminal residue optimization and fragment merging: discovery of a potent Peptide-hybrid inhibitor of dengue protease.Novel dengue virus-specific NS2B/NS3 protease inhibitor, BP2109, discovered by a high-throughput screening assay.Construction of a dengue virus type 4 reporter replicon and analysis of temperature-sensitive mutations in non-structural proteins 3 and 5.Small molecule pan-dengue and West Nile virus NS3 protease inhibitors.The C-terminal 50 amino acid residues of dengue NS3 protein are important for NS3-NS5 interaction and viral replicationA novel dengue virus inhibitor, BP13944, discovered by high-throughput screening with dengue virus replicon cells selects for resistance in the viral NS2B/NS3 proteaseA small molecule inhibitor of dengue virus type 2 protease inhibits the replication of all four dengue virus serotypes in cell culture.Identification of natural antimicrobial agents to treat dengue infection: In vitro analysis of latarcin peptide activity against dengue virus.Discovering new medicines targeting helicases: challenges and recent progress.Policresulen, a novel NS2B/NS3 protease inhibitor, effectively inhibits the replication of DENV2 virus in BHK-21 cells.Inhibitors of Dengue virus and West Nile virus proteases based on the aminobenzamide scaffoldDesign, synthesis and characterization of novel 1,2-benzisothiazol-3(2H)-one and 1,3,4-oxadiazole hybrid derivatives: potent inhibitors of Dengue and West Nile virus NS2B/NS3 proteasesEvolution and heterogeneity of multiple serotypes of Dengue virus in Pakistan, 2006-2011Targeting host factors to treat West Nile and dengue viral infections.Molecular mechanisms involved in the early steps of flavivirus cell entry.Functional interplay among the flavivirus NS3 protease, helicase, and cofactors.
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Towards the design of antiviral inhibitors against flaviviruses: the case for the multifunctional NS3 protein from Dengue virus as a target.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 30 July 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Towards the design of antivira ...... from Dengue virus as a target.
@en
Towards the design of antivira ...... from Dengue virus as a target.
@nl
type
label
Towards the design of antivira ...... from Dengue virus as a target.
@en
Towards the design of antivira ...... from Dengue virus as a target.
@nl
prefLabel
Towards the design of antivira ...... from Dengue virus as a target.
@en
Towards the design of antivira ...... from Dengue virus as a target.
@nl
P2093
P50
P1433
P1476
Towards the design of antivira ...... from Dengue virus as a target.
@en
P2093
Aruna Sampath
Julien Lescar
Subhash G Vasudevan
P304
P356
10.1016/J.ANTIVIRAL.2008.07.001
P577
2008-07-30T00:00:00Z