Temporal pattern of cocaine intake determines tolerance vs sensitization of cocaine effects at the dopamine transporter.
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Excessive cocaine use results from decreased phasic dopamine signaling in the striatumWithdrawal from extended-access cocaine self-administration results in dysregulated functional activity and altered locomotor activity in rats.Methylphenidate amplifies the potency and reinforcing effects of amphetamines by increasing dopamine transporter expression.Sensitized nucleus accumbens dopamine terminal responses to methylphenidate and dopamine transporter releasers after intermittent-access self-administration.Amphetamine self-administration attenuates dopamine D2 autoreceptor function.Adaptations of presynaptic dopamine terminals induced by psychostimulant self-administration.A Single Amphetamine Infusion Reverses Deficits in Dopamine Nerve-Terminal Function Caused by a History of Cocaine Self-Administration.Cocaine Self-Administration Produces Long-Lasting Alterations in Dopamine Transporter Responses to CocaineCocaine self-administration and extinction alter medullary noradrenergic and limbic forebrain cFos responses to acute, noncontingent cocaine injections in adult rats.Extended access of cocaine self-administration results in tolerance to the dopamine-elevating and locomotor-stimulating effects of cocaine.Intermittent cocaine self-administration produces sensitization of stimulant effects at the dopamine transporter.Modeling the development of drug addiction in male and female animals.The individual and combined effects of phenmetrazine and mgluR2/3 agonist LY379268 on the motivation to self-administer cocaine.Less is more: prolonged intermittent access cocaine self-administration produces incentive-sensitization and addiction-like behaviorBrief intermittent cocaine self-administration and abstinence sensitizes cocaine effects on the dopamine transporter and increases drug seeking.High and escalating levels of cocaine intake are dissociable from subsequent incentive motivation for the drug in rats.The ability for cocaine and cocaine-associated cues to compete for attention.One month of cocaine abstinence potentiates rapid dopamine signaling in the nucleus accumbens core.Amphetamine elevates nucleus accumbens dopamine via an action potential-dependent mechanism that is modulated by endocannabinoids.The self-administration of rapidly delivered cocaine promotes increased motivation to take the drug: contributions of prior levels of operant responding and cocaine intake.Enhanced neuronal and blunted hemodynamic reactivity to cocaine in the prefrontal cortex following extended cocaine access: optical imaging study in anesthetized rats.
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Temporal pattern of cocaine intake determines tolerance vs sensitization of cocaine effects at the dopamine transporter.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 30 May 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Temporal pattern of cocaine in ...... s at the dopamine transporter.
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Temporal pattern of cocaine in ...... s at the dopamine transporter.
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type
label
Temporal pattern of cocaine in ...... s at the dopamine transporter.
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Temporal pattern of cocaine in ...... s at the dopamine transporter.
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Temporal pattern of cocaine in ...... s at the dopamine transporter.
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Temporal pattern of cocaine in ...... s at the dopamine transporter.
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P2860
P50
P356
P1476
Temporal pattern of cocaine in ...... ts at the dopamine transporter
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P2093
Benjamin A Zimmer
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P2888
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P356
10.1038/NPP.2013.136
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P577
2013-05-30T00:00:00Z