Oncogenic roles of PRL-3 in FLT3-ITD induced acute myeloid leukaemia. - Wikidata - awgldk - TriplyDB

Oncogenic roles of PRL-3 in FLT3-ITD induced acute myeloid leukaemia.

Oncogenic roles of PRL-3 in FLT3-ITD induced acute myeloid leukaemia.

http://www.wikidata.org/entity/Q37236903

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Antibody Array Revealed PRL-3 Affects Protein Phosphorylation and Cytokine Secretion Significance of oncogenes and tumor suppressor genes in AML prognosis.Investigational inhibitors of PTP4A3 phosphatase as antineoplastic agents.PRL-3 promotes telomere deprotection and chromosomal instability.Independent oncogenic and therapeutic significance of phosphatase PRL-3 in FLT3-ITD-negative acute myeloid leukemia.Downregulated Poly-C binding protein-1 is a novel predictor associated with poor prognosis in Acute Myeloid Leukemia.PRL-3 activates mTORC1 in Cancer Progression.Tapping the treasure of intracellular oncotargets with immunotherapy.Phosphatase of regenerating liver in hematopoietic stem cells and hematological malignancies.Novel Anticancer Agents Based on Targeting the Trimer Interface of the PRL Phosphatase.FLT3-ITD and its current role in acute myeloid leukaemia.Genomic gain of the PRL-3 gene may represent poor prognosis of primary colorectal cancer, and associate with liver metastasis.SH3BGRL as a novel prognostic biomarker is down-regulated in acute myeloid leukemia.Regulatory Mechanisms and Novel Therapeutic Targeting Strategies for Protein Tyrosine Phosphatases.Phosphatase of regenerating liver-3 is expressed in acute lymphoblastic leukemia and mediates leukemic cell adhesion, migration and drug resistance.Consecutive epigenetically-active agent combinations act in ID1-RUNX3-TET2 and HOXA pathways for Flt3ITD+ve AML.Phosphatase of regenerating liver-3 (PRL-3) is overexpressed in classical Hodgkin lymphoma and promotes survival and migration.A loss-of-function genetic screening reveals synergistic targeting of AKT/mTOR and WTN/β-catenin pathways for treatment of AML with high PRL-3 phosphatase.Resistance to FLT3 inhibitors in acute myeloid leukemia: Molecular mechanisms and resensitizing strategies

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Oncogenic roles of PRL-3 in FLT3-ITD induced acute myeloid leukaemia.

http://www.wikidata.org/entity/Q37236903

description

article científic

@ca

article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 08 August 2013

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Oncogenic roles of PRL-3 in FLT3-ITD induced acute myeloid leukaemia.

@en

Oncogenic roles of PRL-3 in FLT3-ITD induced acute myeloid leukaemia.

@nl

type

label

Oncogenic roles of PRL-3 in FLT3-ITD induced acute myeloid leukaemia.

@en

Oncogenic roles of PRL-3 in FLT3-ITD induced acute myeloid leukaemia.

@nl

prefLabel

Oncogenic roles of PRL-3 in FLT3-ITD induced acute myeloid leukaemia.

@en

Oncogenic roles of PRL-3 in FLT3-ITD induced acute myeloid leukaemia.

@nl

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EMBO Molecular Medicine

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Oncogenic roles of PRL-3 in FLT3-ITD induced acute myeloid leukaemia

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Abdul Qader O Al-Aidaroos

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Cheng William Hong

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Hiu Fung Yuen

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Jian Biao Zhou

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Jung Eun Park

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Ke Guo

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Peter J Valk

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Qi Zeng

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Wee Joo Chng

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P2860

Critical role of c-Jun overexpression in liver metastasis of human breast cancer xenograft model

Mouse PRL-2 and PRL-3, two potentially prenylated protein tyrosine phosphatases homologous to PRL-1

TRANSFAC: a database on transcription factors and their DNA binding sites

SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling

Single-agent CEP-701, a novel FLT3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemia.

A phosphatase associated with metastasis of colorectal cancer

Generation of PRL-3- and PRL-1-specific monoclonal antibodies as potential diagnostic markers for cancer metastases

Therapeutic intervention in leukemias that express the activated fms-like tyrosine kinase 3 (FLT3): opportunities and challenges

PRL-3, a metastasis associated tyrosine phosphatase, is involved in FLT3-ITD signaling and implicated in anti-AML therapy

AP-1: a double-edged sword in tumorigenesis

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1351-1366

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scholarly article

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10.1002/EMMM.201202183

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9

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5

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23929599

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