Specificity, affinity and efficacy of iota-conotoxin RXIA, an agonist of voltage-gated sodium channels Na(V)1.2, 1.6 and 1.7.
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Cooccupancy of the outer vestibule of voltage-gated sodium channels by micro-conotoxin KIIIA and saxitoxin or tetrodotoxinThe hitchhiker's guide to the voltage-gated sodium channel galaxyConotoxins That Could Provide Analgesia through Voltage Gated Sodium Channel Inhibitionδ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snailsDiversity of conotoxin gene superfamilies in the venomous snail, Conus victoriaeThe Venom Repertoire of Conus gloriamaris (Chemnitz, 1777), the Glory of the Sea.μ-conotoxin KIIIA derivatives with divergent affinities versus efficacies in blocking voltage-gated sodium channels.Structure, dynamics, and selectivity of the sodium channel blocker mu-conotoxin SIIIA.Conotoxin gene superfamilies.Navβ subunits modulate the inhibition of Nav1.8 by the analgesic gating modifier μO-conotoxin MrVIBΑ- and β-subunit composition of voltage-gated sodium channels investigated with μ-conotoxins and the recently discovered μO§-conotoxin GVIIJ.Selective purification of recombinant neuroactive peptides using the flagellar type III secretion system.Conotoxins targeting neuronal voltage-gated sodium channel subtypes: potential analgesics?Co-expression of Na(V)β subunits alters the kinetics of inhibition of voltage-gated sodium channels by pore-blocking μ-conotoxins.Structural Basis for the Inhibition of Voltage-gated Sodium Channels by Conotoxin μO§-GVIIJ.Pharmacological fractionation of tetrodotoxin-sensitive sodium currents in rat dorsal root ganglion neurons by μ-conotoxinsA disulfide tether stabilizes the block of sodium channels by the conotoxin μO§-GVIIJ.Subtype-selective targeting of voltage-gated sodium channels.The tetrodotoxin receptor of voltage-gated sodium channels--perspectives from interactions with micro-conotoxins.Animal toxins influence voltage-gated sodium channel function.Enhancing the therapeutic potential of peptide toxins.Importance of position 8 in μ-conotoxin KIIIA for voltage-gated sodium channel selectivity.Antimycobacterial Activity: A New Pharmacological Target for Conotoxins Found in the First Reported Conotoxin from Conasprella ximenes.Predicting Structural Details of the Sodium Channel Pore Basing on Animal Toxin Studies
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Specificity, affinity and efficacy of iota-conotoxin RXIA, an agonist of voltage-gated sodium channels Na(V)1.2, 1.6 and 1.7.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 06 April 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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Specificity, affinity and effi ...... hannels Na(V)1.2, 1.6 and 1.7.
@en
Specificity, affinity and effi ...... hannels Na(V)1.2, 1.6 and 1.7.
@nl
type
label
Specificity, affinity and effi ...... hannels Na(V)1.2, 1.6 and 1.7.
@en
Specificity, affinity and effi ...... hannels Na(V)1.2, 1.6 and 1.7.
@nl
prefLabel
Specificity, affinity and effi ...... hannels Na(V)1.2, 1.6 and 1.7.
@en
Specificity, affinity and effi ...... hannels Na(V)1.2, 1.6 and 1.7.
@nl
P2093
P2860
P1476
Specificity, affinity and effi ...... hannels Na(V)1.2, 1.6 and 1.7.
@en
P2093
Baldomero M Olivera
Brian Fiedler
Doju Yoshikami
Grzegorz Bulaj
Layla Azam
Min-Min Zhang
Oga Buczek
Raymond S Norton
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P304
P356
10.1016/J.BCP.2008.03.019
P407
P577
2008-04-06T00:00:00Z