Sulindac selectively inhibits colon tumor cell growth by activating the cGMP/PKG pathway to suppress Wnt/β-catenin signaling.
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A Second WNT for Old Drugs: Drug Repositioning against WNT-Dependent CancersThe role of phosphodiesterase-5 inhibitors in prostatic inflammation: a reviewEmerging role of the β-catenin-PPARγ axis in the pathogenesis of colorectal cancerTargeting the Wnt pathway in human cancers: therapeutic targeting with a focus on OMP-54F28Anti-tumor activity of non-steroidal anti-inflammatory drugs: cyclooxygenase-independent targetsBifunctional Conjugates with Potent Inhibitory Activity Towards Cyclooxygenase and Histone DeacetylaseThe interaction between the Wnt/β-catenin signaling cascade and PKG activation in cancer.Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activityInhibition of phosphodiesterase 5 reduces bone mass by suppression of canonical Wnt signaling.Atopic allergic conditions and colorectal cancer risk in the Multiethnic Cohort StudyThe Role of Nitric Oxide Synthase Uncoupling in Tumor Progression.PDE5 inhibitors as therapeutics for heart disease, diabetes and cancerSulindac metabolites decrease cerebrovascular malformations in CCM3-knockout mice.Phosphodiesterases in non-neoplastic appearing colonic mucosa from patients with colorectal neoplasia.Suppression of β-catenin/TCF transcriptional activity and colon tumor cell growth by dual inhibition of PDE5 and 10.The cyclic GMP/protein kinase G pathway as a therapeutic target in head and neck squamous cell carcinomaC-type natriuretic peptide in combination with sildenafil attenuates proliferation of rhabdomyosarcoma cells.β-catenin nuclear translocation in colorectal cancer cells is suppressed by PDE10A inhibition, cGMP elevation, and activation of PKGRAC1 GTP-ase signals Wnt-beta-catenin pathway mediated integrin-directed metastasis-associated tumor cell phenotypes in triple negative breast cancers.COX-Independent Mechanisms of Cancer Chemoprevention by Anti-Inflammatory Drugs.Mechanisms of action of non-steroidal anti-inflammatory drugs (NSAIDs) and mesalazine in the chemoprevention of colorectal cancer.NSAIDs inhibit tumorigenesis, but how?Consumption of Red/Processed Meat and Colorectal Carcinoma: Possible Mechanisms Underlying the Significant Association.Soluble guanylate cyclase stimulators increase sensitivity to cisplatin in head and neck squamous cell carcinoma cells.Autocrine fibroblast growth factor 18 signaling mediates Wnt-dependent stimulation of CD44-positive human colorectal adenoma cells.Modulating the wnt signaling pathway with small molecules.Ciprofloxacin-Induced Antibacterial Activity Is Attenuated by Phosphodiesterase Inhibitors.Diagnosing phenotypes of single-sample individuals by edge biomarkers.Phosphodiesterase-5 inhibition suppresses colonic inflammation-induced tumorigenesis via blocking the recruitment of MDSC.PDE5 inhibitors enhance the lethality of pemetrexed through inhibition of multiple chaperone proteins and via the actions of cyclic GMP and nitric oxidePhosphodiesterase 10A is overexpressed in lung tumor cells and inhibitors selectively suppress growth by blocking β-catenin and MAPK signaling.Validation of PDE5 as a Chemoprevention Target.Phosphodiesterase type 5 and cancers: progress and challenges.PDE5 inhibition eliminates cancer stem cells via induction of PKA signaling.Paracrine nitric oxide induces expression of cardiac sarcomeric proteins in adult progenitor cells through soluble guanylyl cyclase/cyclic-guanosine monophosphate and Wnt/β-catenin inhibition.New cGMP analogues restrain proliferation and migration of melanoma cells.Identification of genomic expression differences between right-sided and left-sided colon cancer based on bioinformatics analysis.Synergistic Activity for Natural and Synthetic Inhibitors of Angiogenesis Induced by Murine Sarcoma L-1 and Human Kidney Cancer Cells.Deficiency of endothelial nitric oxide signaling pathway exacerbates peritoneal fibrosis in mice.Construction of a ceRNA network reveals potential lncRNA biomarkers in rectal adenocarcinoma.
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Sulindac selectively inhibits colon tumor cell growth by activating the cGMP/PKG pathway to suppress Wnt/β-catenin signaling.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 26 June 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Sulindac selectively inhibits ...... press Wnt/β-catenin signaling.
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Sulindac selectively inhibits ...... press Wnt/β-catenin signaling.
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type
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Sulindac selectively inhibits ...... press Wnt/β-catenin signaling.
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Sulindac selectively inhibits ...... press Wnt/β-catenin signaling.
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Sulindac selectively inhibits ...... press Wnt/β-catenin signaling.
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Sulindac selectively inhibits ...... press Wnt/β-catenin signaling.
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P2093
P2860
P1476
Sulindac selectively inhibits ...... press Wnt/β-catenin signaling.
@en
P2093
Adam B Keeton
Ashraf H Abadi
Bernard D Gary
Evrim Gurpinar
Gary A Piazza
Heather N Tinsley
Margie L Clapper
Mary P Moyer
P2860
P304
P356
10.1158/1535-7163.MCT-13-0048
P577
2013-06-26T00:00:00Z