A gating mechanism of pentameric ligand-gated ion channels.
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Principles and Overview of Sampling Methods for Modeling Macromolecular Structure and DynamicsAnesthetics target interfacial transmembrane sites in nicotinic acetylcholine receptorsThe impact of human hyperekplexia mutations on glycine receptor structure and functionPathways and Barriers for Ion Translocation through the 5-HT3A Receptor ChannelCommon Internal Allosteric Network Links Anesthetic Binding Sites in a Pentameric Ligand-Gated Ion ChannelCrystal structures of a pentameric ligand-gated ion channel provide a mechanism for activationStructural basis for cooperative interactions of substituted 2-aminopyrimidines with the acetylcholine binding proteinCrystal structure of human glycine receptor-α3 bound to antagonist strychnineA predicted binding site for cholesterol on the GABAA receptorIdentification and functional expression of a glutamate- and avermectin-gated chloride channel from Caligus rogercresseyi, a southern Hemisphere sea louse affecting farmed fishA Structural Model of the Human α7 Nicotinic Receptor in an Open ConformationAn Electrostatic Funnel in the GABA-Binding PathwayX-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors.Identification of a pre-active conformation of a pentameric channel receptorMolecular determinants of agonist selectivity in glutamate-gated chloride channels which likely explain the agonist selectivity of the vertebrate glycine and GABAA-ρ receptorsAllosteric regulation of pentameric ligand-gated ion channels: an emerging mechanistic perspectiveA combined coarse-grained and all-atom simulation of TRPV1 channel gating and heat activationLigand-dependent opening of the multiple AMPA receptor conductance states: a concerted modelDeleterious Rare Variants Reveal Risk for Loss of GABAA Receptor Function in Patients with Genetic Epilepsy and in the General Population.Functional characterization of neurotransmitter activation and modulation in a nematode model ligand-gated ion channel.Prediction and validation of protein intermediate states from structurally rich ensembles and coarse-grained simulations.Using molecular dynamics to elucidate the structural basis for function in pLGICsA mechanism for acetylcholine receptor gating based on structure, coupling, phi, and flip.Altered Channel Conductance States and Gating of GABAA Receptors by a Pore Mutation Linked to Dravet Syndrome.Pentameric Ligand-gated Ion Channels : Insights from Computation.Principles of Ocular Pharmacology.Understanding structure-function relationships of the human neuronal acetylcholine receptor: insights from the first crystal structures of neuronal subunits.Toward decrypting the allosteric mechanism of the ryanodine receptor based on coarse-grained structural and dynamic modeling.Genuine open form of the pentameric ligand-gated ion channel GLIC.A role for loop G in the β1 strand in GABAA receptor activation.Temperature-sensitive gating of TRPV1 channel as probed by atomistic simulations of its trans- and juxtamembrane domains.Protein dynamics and the allosteric transitions of pentameric receptor channels.String method solution of the gating pathways for a pentameric ligand-gated ion channel.Un-gating and allosteric modulation of a pentameric ligand-gated ion channel captured by molecular dynamics.Full mutational mapping of titratable residues helps to identify proton-sensors involved in the control of channel gating in the Gloeobacter violaceus pentameric ligand-gated ion channel.Loop G in the GABAA receptor α1 subunit influences gating efficacy.Cyclic activation of endplate acetylcholine receptors.Ivermectin and its target molecules: shared and unique modulation mechanisms of ion channels and receptors by ivermectin.Diversity of Nicotinic Acetylcholine Receptor Positive Allosteric Modulators Revealed by Mutagenesis and a Revised Structural Model.Allosteric modulation as a unifying mechanism for receptor function and regulation.
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A gating mechanism of pentameric ligand-gated ion channels.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 16 September 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A gating mechanism of pentameric ligand-gated ion channels.
@en
A gating mechanism of pentameric ligand-gated ion channels.
@nl
type
label
A gating mechanism of pentameric ligand-gated ion channels.
@en
A gating mechanism of pentameric ligand-gated ion channels.
@nl
prefLabel
A gating mechanism of pentameric ligand-gated ion channels.
@en
A gating mechanism of pentameric ligand-gated ion channels.
@nl
P2093
P2860
P50
P356
P1476
A gating mechanism of pentameric ligand-gated ion channels.
@en
P2093
Jean-Pierre Changeux
Manuel Simoes
Nicolas Calimet
P2860
P304
P356
10.1073/PNAS.1313785110
P407
P577
2013-09-16T00:00:00Z