Modulation of dendritic cells using granulocyte-macrophage colony-stimulating factor (GM-CSF) delays type 1 diabetes by enhancing CD4+CD25+ regulatory T cell function
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GM-CSF: An immune modulatory cytokine that can suppress autoimmunityNeuroantigen-specific, tolerogenic vaccines: GM-CSF is a fusion partner that facilitates tolerance rather than immunity to dominant self-epitopes of myelin in murine models of experimental autoimmune encephalomyelitis (EAE).Pre-existing autoimmunity determines type 1 diabetes outcome after Flt3-ligand treatment.Dendritic cell-directed CTLA-4 engagement during pancreatic beta cell antigen presentation delays type 1 diabetes.IL-1β promotes TGF-β1 and IL-2 dependent Foxp3 expression in regulatory T cells.GM-CSF-neuroantigen fusion proteins reverse experimental autoimmune encephalomyelitis and mediate tolerogenic activity in adjuvant-primed environments: association with inflammation-dependent, inhibitory antigen presentation.GM-CSF-induced, bone-marrow-derived dendritic cells can expand natural Tregs and induce adaptive Tregs by different mechanisms.Suppression of Th1-mediated autoimmunity by embryonic stem cell-derived dendritic cellsGranulocyte-macrophage colony stimulating factor blockade promotes ccr9(+) lymphocyte expansion in Nod2 deficient mice.Impaired circulating CD4+ LAP+ regulatory T cells in patients with acute coronary syndrome and its mechanistic study.Role of cytokines in the pathogenesis and suppression of thyroid autoimmunity.Recombinant IgG2a Fc (M045) multimers effectively suppress experimental autoimmune myasthenia gravis.Dual Role of GM-CSF as a Pro-Inflammatory and a Regulatory Cytokine: Implications for Immune Therapy.A combination hydrogel microparticle-based vaccine prevents type 1 diabetes in non-obese diabetic mice.Children with islet autoimmunity and enterovirus infection demonstrate a distinct cytokine profileA combination dual-sized microparticle system modulates dendritic cells and prevents type 1 diabetes in prediabetic NOD mice.Cytokine-neuroantigen fusion proteins as a new class of tolerogenic, therapeutic vaccines for treatment of inflammatory demyelinating disease in rodent models of multiple sclerosisImpaired thymic export and increased apoptosis account for regulatory T cell defects in patients with non-ST segment elevation acute coronary syndrome.GM-CSF and the role of myeloid regulatory cells in the pathogenesis and treatment of Crohn's disease.Injectable, Pore-Forming Hydrogels for In Vivo Enrichment of Immature Dendritic Cells.Targeting regulatory T cells in the treatment of type 1 diabetes mellitus.GM-CSF-induced CD11c+CD8a--dendritic cells facilitate Foxp3+ and IL-10+ regulatory T cell expansion resulting in suppression of autoimmune thyroiditisTransfusion of nonobese diabetic mice with allogeneic newborn blood ameliorates autoimmune diabetes and modifies the expression of selected immune response genes.IL-25 attenuates rheumatoid arthritis through suppression of Th17 immune responses in an IL-13-dependent mannerSoluble OX40L and JAG1 Induce Selective Proliferation of Functional Regulatory T-Cells Independent of canonical TCR signalingMouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease.Multifunctional dendritic cell-targeting polymeric microparticles: engineering new vaccines for type 1 diabetes.Granulocyte macrophage colony-stimulating factor and the intestinal innate immune cell homeostasis in Crohn's disease.OX40L/Jagged1 cosignaling by GM-CSF-induced bone marrow-derived dendritic cells is required for the expansion of functional regulatory T cells.PKC-ѳ is dispensable for OX40L-induced TCR-independent Treg proliferation but contributes by enabling IL-2 production from effector T-cells.Age-dependent divergent effects of OX40L treatment on the development of diabetes in NOD mice.Depletion of CD4+ CD25+ regulatory T cells confers susceptibility to experimental autoimmune encephalomyelitis (EAE) in GM-CSF-deficient Csf2-/- mice.Ex vivo expansion of human Tregs by rabbit ATG is dependent on intact STAT3-signaling in CD4⁺ T cells and requires the presence of monocytes.Harnessing the power of regulatory T-cells to control autoimmune diabetes: overview and perspective.Low frequency of regulatory T cells in the peripheral blood of children with type 1 diabetes diagnosed under the age of five.Small-molecule inhibitor sorafenib regulates immunoreactions by inducing survival and differentiation of bone marrow cells.Human milk oligosaccharides protect against the development of autoimmune diabetes in NOD-mice.Tolerogenic bone marrow-derived dendritic cells induce neuroprotective regulatory T cells in a model of Parkinson's disease.Introduction of Human Flt3-L and GM-CSF into Humanized Mice Enhances the Reconstitution and Maturation of Myeloid Dendritic Cells and the Development of Foxp3+CD4+ T Cells.Identification of a Novel OX40L Dendritic Cell Subset That Selectively Expands Regulatory T cells
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Modulation of dendritic cells using granulocyte-macrophage colony-stimulating factor (GM-CSF) delays type 1 diabetes by enhancing CD4+CD25+ regulatory T cell function
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 25 January 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Modulation of dendritic cells ...... 25+ regulatory T cell function
@en
Modulation of dendritic cells using granulocyte-macrophage colony-stimulating factor
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type
label
Modulation of dendritic cells ...... 25+ regulatory T cell function
@en
Modulation of dendritic cells using granulocyte-macrophage colony-stimulating factor
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prefLabel
Modulation of dendritic cells ...... 25+ regulatory T cell function
@en
Modulation of dendritic cells using granulocyte-macrophage colony-stimulating factor
@nl
P2093
P2860
P1433
P1476
Modulation of dendritic cells ...... 25+ regulatory T cell function
@en
P2093
Balaji B Ganesh
Bellur S Prabhakar
Donald Cheatem
Eryn Gangi
P2860
P304
P356
10.1016/J.CLIM.2008.12.001
P577
2009-01-25T00:00:00Z