Presenilins: members of the gamma-secretase quartets, but part-time soloists too.
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Amyloid-beta Alzheimer targets - protein processing, lipid rafts, and amyloid-beta poresGenes associated with Alzheimer's disease: an overview and current statusThe genetics and neuropathology of Alzheimer's diseasePotential use of γ-secretase modulators in the treatment of Alzheimer diseasePeptides of presenilin-1 bind the amyloid precursor protein ectodomain and offer a novel and specific therapeutic approach to reduce ß-amyloid in Alzheimer's diseasePresenilin/gamma-secretase cleaves CD46 in response to Neisseria infectionPresenilin controls kinesin-1 and dynein function during APP-vesicle transport in vivoA model to explain specific cellular communications and cellular harmony:- a hypothesis of coupled cells and interactive coupling molecules.Alzheimer's disease-linked mutations in presenilin-1 result in a drastic loss of activity in purified γ-secretase complexes.Gene expression profiling in cells with enhanced gamma-secretase activity.Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease.Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606.An overview of APP processing enzymes and products.Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process.Amyloid precursor protein (APP) mediated regulation of ganglioside homeostasis linking Alzheimer's disease pathology with ganglioside metabolism.And four equals one: presenilin takes the gamma-secretase role by itself.Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk.Plasmalogen synthesis is regulated via alkyl-dihydroxyacetonephosphate-synthase by amyloid precursor protein processing and is affected in Alzheimer's disease.Loss of presenilin 2 is associated with increased iPLA2 activity and lung tumor development.The Coxsackievirus and Adenovirus Receptor (CAR) undergoes ectodomain shedding and regulated intramembrane proteolysis (RIP).Intracellular APP Domain Regulates Serine-Palmitoyl-CoA Transferase Expression and Is Affected in Alzheimer's Disease.Neurotrophins regulate ApoER2 proteolysis through activation of the Trk signaling pathway.Structural and mechanistic commonalities of amyloid-β and the prion proteinPresenilins and γ-secretase: structure, function, and role in Alzheimer Disease.The mechanism of γ-Secretase dysfunction in familial Alzheimer disease.RNAi-mediated inhibition of presenilin 2 inhibits glioma cell growth and invasion and is involved in the regulation of Nrg1/ErbB signaling.γ-Secretase Activity Is Required for Regulated Intramembrane Proteolysis of Tumor Necrosis Factor (TNF) Receptor 1 and TNF-mediated Pro-apoptotic Signaling.Toward structural elucidation of the gamma-secretase complex.Reassessing the amyloid cascade hypothesis of Alzheimer's diseasePresenilins are enriched in endoplasmic reticulum membranes associated with mitochondria.Signature amyloid β profiles are produced by different γ-secretase complexes.Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid β peptide variant and augment the production of multiple carboxy-truncated amyloid β species.The structure and function of Alzheimer's gamma secretase enzyme complex.The child is father to the man: developmental roles for proteins of importance for neurodegenerative disease.PET translates neurophysiology into images: A review to stimulate a network between neuroimaging and basic research.Presenilins in synaptic function and disease.Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and presenilin.Targeting synaptic dysfunction in Alzheimer's disease therapy.Regulated intramembrane proteolysis of the TGFβ type I receptor conveys oncogenic signals.Alzheimer's disease genetics: from the bench to the clinic.
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Presenilins: members of the gamma-secretase quartets, but part-time soloists too.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on August 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Presenilins: members of the gamma-secretase quartets, but part-time soloists too.
@en
Presenilins: members of the gamma-secretase quartets, but part-time soloists too.
@nl
type
label
Presenilins: members of the gamma-secretase quartets, but part-time soloists too.
@en
Presenilins: members of the gamma-secretase quartets, but part-time soloists too.
@nl
prefLabel
Presenilins: members of the gamma-secretase quartets, but part-time soloists too.
@en
Presenilins: members of the gamma-secretase quartets, but part-time soloists too.
@nl
P2860
P1433
P1476
Presenilins: members of the gamma-secretase quartets, but part-time soloists too.
@en
P2093
Tomoko Wakabayashi
P2860
P304
P356
10.1152/PHYSIOL.00009.2008
P577
2008-08-01T00:00:00Z