Adenovirus-mediated interleukin-12 gene therapy for metastatic colon carcinoma.
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Antiangiogenic gene therapy of cancer: recent developmentsInterleukin 12: still a promising candidate for tumor immunotherapy?Cloning and characterization of an adenoviral vector for highly efficient and doxycycline-suppressible expression of bioactive human single-chain interleukin 12 in colon cancer.Immune stimulatory receptor CD40 is required for T-cell suppression and T regulatory cell activation mediated by myeloid-derived suppressor cells in cancer.Strategy of liver-directed gene therapy: present status and future prospects.Therapeutic and tumor-specific immunity induced by combination of dendritic cells and oncolytic adenovirus expressing IL-12 and 4-1BBL.Engineered herpes simplex virus expressing IL-12 in the treatment of experimental murine brain tumors.Regulatable gene expression systems for gene therapy applications: progress and future challenges.Therapy of cancer by cytokines mediated by gene therapy approach.Design of a Phase I Clinical Trial to Evaluate M032, a Genetically Engineered HSV-1 Expressing IL-12, in Patients with Recurrent/Progressive Glioblastoma Multiforme, Anaplastic Astrocytoma, or Gliosarcoma.Myeloid-derived suppressor cells as a vehicle for tumor-specific oncolytic viral therapy.Immunotherapy for liver tumors: present status and future prospects.Gene therapy via inducible nitric oxide synthase: a tool for the treatment of a diverse range of pathological conditions.Heparin-binding epidermal growth factor-like growth factor and hepatocyte growth factor inhibit cholestatic liver injury in mice through different mechanisms.Oncolytic adenovirus coexpressing interleukin-12 and decorin overcomes Treg-mediated immunosuppression inducing potent antitumor effects in a weakly immunogenic tumor model.Pancreatic cancer escape variants that evade immunogene therapy through loss of sensitivity to IFNgamma-induced apoptosis.Gene therapy approaches against cancer using in vivo and ex vivo gene transfer of interleukin-12.Treatment of pancreatic cancer with an oncolytic adenovirus expressing interleukin-12 in Syrian hamsters.The antitumor activity of TRAIL and IL-24 with replicating oncolytic adenovirus in colorectal cancer.Monocyte chemoattractant protein-1 gene delivery enhances antitumor effects of herpes simplex virus thymidine kinase/ganciclovir system in a model of colon cancer.The systemic administration of Ig-4-1BB ligand in combination with IL-12 gene transfer eradicates hepatic colon carcinoma.Dendritic cell immunotherapy with poly(D,L-2,4-diaminobutyric acid)-mediated intratumoral delivery of the interleukin-12 gene suppresses tumor growth significantly.An efficient construction of conditionally replicating adenoviruses that target tumor cells with multiple factors.Effective transfer of interleukin-12 gene to solid tumors using a novel gene delivery system, poly [D,L-2,4-diaminobutyric acid].Can immunotherapy by gene transfer tip the balance against colorectal cancer?Anti-tumor immunity induced by interleukin-12 gene therapy in a metastatic model of breast cancer is mediated by natural killer cells.Adenovirus-mediated interleukin-12 gene therapy for prostate cancer: suppression of orthotopic tumor growth and pre-established lung metastases in an orthotopic model.Reversal of gastrointestinal carcinoma-induced immunosuppression and induction of antitumoural immunity by a combination of cyclophosphamide and gene transfer of IL-12.The promise and reality of cancer gene therapy.Construction of IL-2 gene-modified human hepatocyte and its cultivation with microcarrier.Local administration of IL-12-transfected dendritic cells induces antitumor immune responses to colon adenocarcinoma in the liver in mice.AV.TK-mediated killing of subcutaneous tumors in situ results in effective immunization against established secondary intracranial tumor deposits.A novel bystander effect involving tumor cell-derived Fas and FasL interactions following Ad.HSV-tk and Ad.mIL-12 gene therapies in experimental prostate cancer.Biodegradable polymer-based interleukin-12 gene delivery: role of induced cytokines, tumor infiltrating cells and nitric oxide in anti-tumor activity.Large nontransplanted hepatocellular carcinoma in woodchucks: treatment with adenovirus-mediated delivery of interleukin 12/B7.1 genes.Highly suppressible expression of single-chain interleukin-12 by doxycycline following adenoviral infection with a single-vector Tet-regulatory system.Adjuvant interleukin-12 gene therapy for the management of colorectal liver metastases.Transfer of the murine interleukin-12 gene in vivo by a Semliki Forest virus vector induces B16 tumor regression through inhibition of tumor blood vessel formation monitored by Doppler ultrasonography.Role of NK and T cells in IL-12-induced anti-tumor response against hepatic colon carcinoma.Gene expression and antitumor effects following direct interferon (IFN)-gamma gene transfer with naked plasmid DNA and DC-chol liposome complexes in mice.
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Adenovirus-mediated interleukin-12 gene therapy for metastatic colon carcinoma.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on October 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Adenovirus-mediated interleukin-12 gene therapy for metastatic colon carcinoma.
@en
Adenovirus-mediated interleukin-12 gene therapy for metastatic colon carcinoma.
@nl
type
label
Adenovirus-mediated interleukin-12 gene therapy for metastatic colon carcinoma.
@en
Adenovirus-mediated interleukin-12 gene therapy for metastatic colon carcinoma.
@nl
prefLabel
Adenovirus-mediated interleukin-12 gene therapy for metastatic colon carcinoma.
@en
Adenovirus-mediated interleukin-12 gene therapy for metastatic colon carcinoma.
@nl
P2093
P2860
P921
P356
P1476
Adenovirus-mediated interleukin-12 gene therapy for metastatic colon carcinoma.
@en
P2093
K Pham-Nguyen
M Finegold
P2860
P304
11302-11306
P356
10.1073/PNAS.93.21.11302
P407
P577
1996-10-01T00:00:00Z