Helix movement is coupled to displacement of the second extracellular loop in rhodopsin activation.
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Structure and function of an irreversible agonist-β(2) adrenoceptor complexLigand-specific regulation of the extracellular surface of a G-protein-coupled receptorStructure of the Disulfide Bond Generating Membrane Protein DsbB in the Lipid BilayerStabilized G protein binding site in the structure of constitutively active metarhodopsin-IISolid-state NMR spectroscopy structure determination of a lipid-embedded heptahelical membrane proteinUnderstanding functional residues of the cannabinoid CB1.Transmembrane signal transduction by peptide hormones via family B G protein-coupled receptorsMembrane proteins in their native habitat as seen by solid-state NMR spectroscopyPredicting novel binding modes of agonists to β adrenergic receptors using all-atom molecular dynamics simulationsSequence, structure and ligand binding evolution of rhodopsin-like G protein-coupled receptors: a crystal structure-based phylogenetic analysisResidue Geometry Networks: A Rigidity-Based Approach to the Amino Acid Network and Evolutionary Rate AnalysisThe structure and function of G-protein-coupled receptorsHydrogen/Deuterium Exchange Mass Spectrometry of Human Green Opsin Reveals a Conserved Pro-Pro Motif in Extracellular Loop 2 of Monostable Visual G Protein-Coupled Receptors.Lipid bilayer-bound conformation of an integral membrane beta barrel protein by multidimensional MAS NMR.Structural waters define a functional channel mediating activation of the GPCR, rhodopsin.Unraveling the structure and function of G protein-coupled receptors through NMR spectroscopy.Molecular simulations and solid-state NMR investigate dynamical structure in rhodopsin activation.Membrane protein structure and dynamics from NMR spectroscopy.G-protein-coupled receptor structure, ligand binding and activation as studied by solid-state NMR spectroscopy.Structure-based simulations reveal concerted dynamics of GPCR activationComparative sequence and structural analyses of G-protein-coupled receptor crystal structures and implications for molecular models.Microsecond time-resolved circular dichroism of rhodopsin photointermediates.Rhodopsin and the others: a historical perspective on structural studies of G protein-coupled receptors.Analysis of transmembrane domains 1 and 4 of the human angiotensin II AT1 receptor by cysteine-scanning mutagenesis.Conformational equilibria of light-activated rhodopsin in nanodiscs.Temperature dependence of the lumirhodopsin I-lumirhodopsin II equilibriumGlobal fold of human cannabinoid type 2 receptor probed by solid-state 13C-, 15N-MAS NMR and molecular dynamics simulations.Sequential rearrangement of interhelical networks upon rhodopsin activation in membranes: the Meta II(a) conformational substate.Ligand-specific conformation of extracellular loop-2 in the angiotensin II type 1 receptor.Relationships between structural dynamics and functional kinetics in oligomeric membrane receptorsPutative active states of a prototypic g-protein-coupled receptor from biased molecular dynamics.Ligand-dependent activation and deactivation of the human adenosine A(2A) receptor.Structure and function of G protein-coupled receptors using NMR spectroscopy.A novel biased allosteric compound inhibitor of parturition selectively impedes the prostaglandin F2alpha-mediated Rho/ROCK signaling pathwayThe year in G protein-coupled receptor research.Site-directed mutations and the polymorphic variant Ala160Thr in the human thromboxane receptor uncover a structural role for transmembrane helix 4Action of molecular switches in GPCRs--theoretical and experimental studies.A minimal ligand binding pocket within a network of correlated mutations identified by multiple sequence and structural analysis of G protein coupled receptors.QM/MM study of dehydro and dihydro β-ionone retinal analogues in squid and bovine rhodopsins: implications for vision in salamander rhodopsin.Highly conserved tyrosine stabilizes the active state of rhodopsin.
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Helix movement is coupled to displacement of the second extracellular loop in rhodopsin activation.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on February 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Helix movement is coupled to d ...... loop in rhodopsin activation.
@en
Helix movement is coupled to d ...... loop in rhodopsin activation.
@nl
type
label
Helix movement is coupled to d ...... loop in rhodopsin activation.
@en
Helix movement is coupled to d ...... loop in rhodopsin activation.
@nl
prefLabel
Helix movement is coupled to d ...... loop in rhodopsin activation.
@en
Helix movement is coupled to d ...... loop in rhodopsin activation.
@nl
P2093
P2860
P356
P1476
Helix movement is coupled to d ...... r loop in rhodopsin activation
@en
P2093
Amiram Hirshfeld
Elsa C Y Yan
Joseph A Goncalves
Markus Eilers
Martine Ziliox
Mordechai Sheves
Natalie Syrett
Philip J Reeves
Shivani Ahuja
Steven O Smith
P2860
P2888
P304
P356
10.1038/NSMB.1549
P577
2009-02-01T00:00:00Z