The selective alpha7 agonist GTS-21 attenuates cytokine production in human whole blood and human monocytes activated by ligands for TLR2, TLR3, TLR4, TLR9, and RAGE. - Wikidata - awgldk - TriplyDB

The selective alpha7 agonist GTS-21 attenuates cytokine production in human whole blood and human monocytes activated by ligands for TLR2, TLR3, TLR4, TLR9, and RAGE.

The selective alpha7 agonist GTS-21 attenuates cytokine production in human whole blood and human monocytes activated by ligands for TLR2, TLR3, TLR4, TLR9, and RAGE.

http://www.wikidata.org/entity/Q37254561

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The chimeric gene CHRFAM7A, a partial duplication of the CHRNA7 gene, is a dominant negative regulator of α7*nAChR function Alpha7 nicotinic acetylcholine receptor is a target in pharmacology and toxicology Modulatory effects of α7 nAChRs on the immune system and its relevance for CNS disorders Role of α7 nicotinic receptor in the immune system and intracellular signaling pathways A review of experimental evidence linking neurotoxic organophosphorus compounds and inflammation Reflex principles of immunological homeostasis Nicotinic Activity of Arecoline, the Psychoactive Element of "Betel Nuts", Suggests a Basis for Habitual Use and Anti-Inflammatory Activity From hypertension to stroke: mechanisms and potential prevention strategies.Identification and characterization of poly(I:C)-induced molecular responses attenuated by nicotine in mouse macrophages.Inhibition of Toll-like receptor 2-mediated interleukin-8 production in Cystic Fibrosis airway epithelial cells via the alpha7-nicotinic acetylcholine receptor Neuroimmune Interactions in Schizophrenia: Focus on Vagus Nerve Stimulation and Activation of the Alpha-7 Nicotinic Acetylcholine Receptor Intrathecal injection of an alpha seven nicotinic acetylcholine receptor agonist attenuates gp120-induced mechanical allodynia and spinal pro-inflammatory cytokine profiles in rats.Vagus nerve through α7 nAChR modulates lung infection and inflammation: models, cells, and signals Whole blood cytokine attenuation by cholinergic agonists ex vivo and relationship to vagus nerve activity in rheumatoid arthritis.The minimal pharmacophore for silent agonism of the α7 nicotinic acetylcholine receptor.Design, synthesis, and pharmacological characterization of novel spirocyclic quinuclidinyl-Δ2-isoxazoline derivatives as potent and selective agonists of α7 nicotinic acetylcholine receptors.Cardiopulmonary arrest and resuscitation disrupts cholinergic anti-inflammatory processes: a role for cholinergic α7 nicotinic receptors.Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit Merging old and new perspectives on nicotinic acetylcholine receptors α7 nicotinic acetylcholine receptor signaling inhibits inflammasome activation by preventing mitochondrial DNA release.HMGB1 mediates splenomegaly and expansion of splenic CD11b+ Ly-6C(high) inflammatory monocytes in murine sepsis survivors.High-mobility group box-1 induces proinflammatory cytokines production of Kupffer cells through TLRs-dependent signaling pathway after burn injury Nicotinic receptor alpha7 expression identifies a novel hematopoietic progenitor lineage.HMGB1 in health and disease.JAK2 inhibition prevents innate immune responses and rescues animals from sepsis.A human in vitro whole blood assay to predict the systemic cytokine response to therapeutic oligonucleotides including siRNA The interface between cholinergic pathways and the immune system and its relevance to arthritis Reduced size and macrophage content of advanced atherosclerotic lesions in mice with bone marrow specific deficiency of alpha 7 nicotinic acetylcholine receptor Soluble amyloid triggers a myeloid differentiation factor 88 and interferon regulatory factor 7 dependent neuronal type-1 interferon response in vitro Chronic stress and Alzheimer's disease-like pathogenesis in a rat model: prevention by nicotine.Neutrophils in periodontal inflammation α7 nicotinic acetylcholine receptor (α7nAChR) expression in bone marrow-derived non-T cells is required for the inflammatory reflex.Neural reflexes in inflammation and immunity Acetylcholine and an acetylcholinesterase inhibitor neostigmine can aggravate tularemia progress in BALB/c mice.Cholinergic anti-inflammatory pathway activity in dialysis patients: a role for neuroimmunomodulation?High-mobility group box 1 mediates persistent splenocyte priming in sepsis survivors: evidence from a murine model Lipopolysaccharide upregulates α7 acetylcholine receptors: stimulation with GTS-21 mitigates growth arrest of macrophages and improves survival in burned mice Dissection of N,N-diethyl-N'-phenylpiperazines as α7 nicotinic receptor silent agonists Vagus nerve stimulation inhibits cytokine production and attenuates disease severity in rheumatoid arthritis.The Molecular and Pharmacological Mechanisms of HIV-Related Neuropathic Pain.

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The selective alpha7 agonist GTS-21 attenuates cytokine production in human whole blood and human monocytes activated by ligands for TLR2, TLR3, TLR4, TLR9, and RAGE.

http://www.wikidata.org/entity/Q37254561

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article científic

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article scientifique

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scientific article published on 27 April 2009

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vedecký článok

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The selective alpha7 agonist G ...... 2, TLR3, TLR4, TLR9, and RAGE.

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The selective alpha7 agonist G ...... 2, TLR3, TLR4, TLR9, and RAGE.

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The selective alpha7 agonist G ...... 2, TLR3, TLR4, TLR9, and RAGE.

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The selective alpha7 agonist G ...... 2, TLR3, TLR4, TLR9, and RAGE.

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The selective alpha7 agonist G ...... 2, TLR3, TLR4, TLR9, and RAGE.

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The selective alpha7 agonist G ...... 2, TLR3, TLR4, TLR9, and RAGE.

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MOLMED.2009.00039

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Molecular Medicine

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The selective alpha7 agonist G ...... 2, TLR3, TLR4, TLR9, and RAGE.

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P2093

Huan Yang

http://www.w3.org/2001/XMLSchema#string

Lihong Yang

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Margot Gallowitsch-Puerta

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Mauricio Rosas-Ballina

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Nirav B Patel

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Richard S Goldstein

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Sangeeta Chavan

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Yousef Al-Abed

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P2860

Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine

RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease

Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation

HMG-1 as a late mediator of endotoxin lethality in mice

Attenuation of catecholamine-induced immunosuppression in whole blood from patients with sepsis

RAGE is the major receptor for the proinflammatory activity of HMGB1 in rodent macrophages

High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes

Recombinant HMGB1 with cytokine-stimulating activity

Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin

Effect of catecholamines on intracellular cytokine synthesis in human monocytes.

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molmed.2009.00039

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195-202

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10.2119/MOLMED.2009.00039

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7-8

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15

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Kevin J. Tracey

Sergio I Valdés-Ferrer

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2009-04-27T00:00:00Z

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26662306

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1068965197

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19593403

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Toll-like receptor

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